Searched for: subject:"Infant"
(1 - 20 of 324)

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Olga, L. (author), van Diepen, J.A. (author), Bobeldijk-Pastorova, I. (author), Gross, G. (author), Prentice, S.M. (author), Snowden, S.G. (author), Furse, S. (author), Kooistra, T. (author), Hughes, I.A. (author), Schoemaker, M.H. (author), van Tol, E.A.F. (author), van Duyvenvoorde, W. (author), Wielinga, P.Y. (author), Ong, K.K. (author), Dunger, D.B. (author), Kleemann, R. (author), Koulman, A. (author)
Background: Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management. Here, a lipidomic approach was used to identify circulating markers for future obesity risk in translational murine models and validate in a human infant cohort. Methods:...
article 2021
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van Groen, B.D. (author), Krekels, E.H.J. (author), Mooij, M.G. (author), van Duijn, E. (author), Vaes, W.H.J. (author), Windhorst, A.D. (author), van Rosmalen, J. (author), Hartman, S.J.F. (author), Hendrikse, N.H. (author), Koch, B.C.P. (author), Allegaert, K. (author), Tibboel, D. (author), Knibbe, C.A.J. (author), de Wildt, S.N. (author)
Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug-metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to children, yet knowledge is lacking on the oral bioavailability in term neonates up until 1 year of age. Furthermore, the dispositions of the major metabolites 1-OH...
article 2021
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in de Bakker, R. (author)
In some parts of the world, women have access to all the care they need to have a well-monitored and safe pregnancy, and to give birth to a healthy child. But in developing countries, especially in rural areas, access to effective antenatal care is far from ideal. Every year, hundreds of thousands of women and children die in childbirth from...
other 2020
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Stroek, K. (author), Heijboer, A.C. (author), Bouva, M.J. (author), van der Ploeg, C.P.B. (author), Heijnen, M.L.A. (author), Weijman, G. (author), Bosch, A.M. (author), de Jonge, R. (author), Schielen, P.C.J.I. (author), van Trotsenburg, A.S.P. (author), Boelen, A. (author)
Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the hypothalamus or pituitary (central CH, CH-C). The Dutch Newborn Screening (NBS) strategy is primarily based on determination of thyroxine (T4) concentrations in dried blood spots followed,...
article 2020
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Kaan, A.M. (author), Buijs, M.J. (author), Brandt, B.W. (author), Crielaard, W. (author), Keijser, B.J.F. (author), de Ruyter, J.C. (author), Zaura, E. (author)
Objectives: Large longitudinal cohort studies in infants are needed to understand oral microbiome maturation in relation to general health. The logistics of such studies are complex and costs involved high. Methods like home sampling by caretakers might be a solution to these issues. This study aimed to evaluate feasibility of home sampling by...
article 2020
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Wang, L. (author), Jansen, W. (author), van Grieken, A. (author), Vlasblom, J.L.D. (author), Boere-Boonekamp, M.M. (author), L'Hoir, M.P. (author), Raat, H. (author)
BACKGROUND: To identify the patterns of lifestyle behaviours in children aged 3 years, to investigate the parental and child characteristics associated with the lifestyle patterns, and to examine whether the identified lifestyle patterns are associated with child BMI and weight status. METHODS: Cross-sectional data of 2090 children 3 years old...
article 2020
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van Esch, B.C.A.M. (author), van Bilsen, J.H.M. (author), Gros- van Hest, M. (author), Kleinjans, L. (author), Belzer, C. (author), Jeurink, P.V. (author), Garssen, J. (author), Smit, J.J. (author), Pieters, R.H.H. (author), Knippels, L.M. (author)
Introduction This 4-center study is part of a project to validate a food allergy murine model for safety testing of hydrolyzed infant formulas. Aim The aim of the current multi-center experiment was to evaluate the residual allergenicity of three partial hydrolyzed whey proteins (pWH) in a multiple-parameter cow’s milk allergy murine model and...
article 2020
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van Groen, B.D. (author), van de Steeg, E. (author), Mooij, M.G. (author), van Lipzig, M.M.H. (author), de Koning, B.A.E. (author), Verdijk, R.M. (author), Wortelboer, H.M. (author), Gaedigk, R. (author), Bi, C. (author), Leeder, S. (author), van Schaik, R.H.N. (author), van Rosmalen, J. (author), Tibboel, D. (author), Vaes, W.H. (author), de Wildt, S.N. (author)
Background Hepatic membrane transporters are involved in the transport of many endogenous and exogenous compounds, including drugs. We aimed to study the relation of age with absolute transporter protein expression in a cohort of 62 mainly fetus and newborn samples. Methods Protein expressions of BCRP, BSEP, GLUT1, MCT1, MDR1, MRP1, MRP2, MRP3,...
article 2018
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Siddiqui, A. (author), Cuttini, M. (author), Wood, R. (author), Velebil, P. (author), Delnord, M. (author), Zile, I. (author), Barros, H. (author), Gissler, M. (author), Hindori-Mohangoo, A.D. (author), Blondel, B. (author), Zeitlin, J. (author), Haidinger, G. (author), Alexander, S. (author), Pavlou, P. (author), Mortensen, L. (author), Sakkeus, L. (author), Lack, N. (author), Antsaklis, A. (author), Berbik, I. (author), Ólafsdóttir, H.S. (author), Bonham, S. (author), Misins, J. (author), Jaselioniene, J. (author), Wagener, Y. (author), Gatt, M. (author), Nijhuis, J. (author), Klungsøyr, K. (author), Szamotulska, K. (author), Horga, M. (author), Cap, J. (author), Mandić, N.T. (author), Bolúmar, F. (author), Gottvall, K. (author), Berrut, S. (author), Macfarlane, A. (author), Euro-Peristat Scientific Committee (author)
Background: The Apgar score has been shown to be predictive of neonatal mortality in clinical and population studies, but has not been used for international comparisons. We examined population-level distributions in Apgar scores and associations with neonatal mortality in Europe. Methods: Aggregate data on the 5 minute Apgar score for live...
article 2017
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van Zwicht, B.S. (author), Crone, M.R. (author), van Lith, J.M. (author), Rijnders, M.E. (author)
Background. CenteringPregnancy (CP) is a multifaceted group based care-model integrated in routine prenatal care, combining health assessment, education, and support. CP has shown some positive results on perinatal outcomes. However, the effects are less obvious when limited to the results of randomized controlled trials: as there are few trials...
article 2016
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Hovi, P. (author), Vohr, B. (author), Ment, L.R. (author), Doyle, L.W. (author), McGarvey, L. (author), Morrison, K.M. (author), Evensen, K.A.I. (author), van der Pal, S. (author), Grunau, R.E. (author), Brubakk, A.M. (author), Andersson, S. (author), Saigal, S. (author), Kajantie, E. (author)
Adults born preterm at very low birth weight (VLBW; <1500 g) have higher blood pressure than those born at term. It is not known whether all VLBW adults are at risk or whether higher blood pressure could be attributed to some of the specific conditions underlying or accompanying preterm birth. To identify possible risk or protective factors, we...
article 2016
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Joustra, S.D. (author), van der Plas, E.M. (author), Goede, J. (author), Oostdijk, W. (author), Delemarre-van de Waal, H.A. (author), Hack, W.W.M. (author), van Buuren, S. (author), Wit, J.M. (author)
Aim Accurate calculations of testicular volume standard deviation (SD) scores are not currently available. We constructed LMS-smoothed age-reference charts for testicular volume in healthy boys. Methods The LMS method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy...
article 2015
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van Buuren, S. (author), Bezemer, R.A. (author), Reijneveld, S.A. (author), L' Hoir, M.P. (author)
Curve matching is a new big data technique to predict an outcome given earlier measurements. Here we apply curve matching to predict the future growth of a specific child, the target child. The method searches in large datasets of longitudinal growth data for other children who are similar to the target child in terms of factors that influence...
article 2015
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Garner, C.R. (author), Park, K.B. (author), French, N.S. (author), Earnshaw, C. (author), Schipani, A. (author), Selby, A.M. (author), Byrne, L. (author), Siner, S. (author), Crawley, F.P. (author), Vaes, W.H.J. (author), van Duijn, E. (author), de ligt, R. (author), Varendi, H. (author), Lass, J. (author), Grynkiewicz, G. (author), Maruszak, W. (author), Turner, M.A. (author)
Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group. Methods [14C]-PARA concentrations in 10-15 μl...
article 2015
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van Gendt, A.W. (author), van der Pal, S.M. (author), Hermes, W. (author), Walther, F.J. (author), van der Pal-de Bruin, K.M. (author), de Groot, C.J.M. (author)
The aims of this study were to analyze reproductive outcomes of women and men born very preterm (gestational age <32 weeks) or with a very low birth weight (<1500 g) in 1983 in the Netherlands and to compare their reproductive outcomes with the total population at a similar age of 28 years. Young adults who were born after a pregnancy...
article 2015
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Hayes, D.J. (author), van Buuren, S. (author), ter Kuile, F.O. (author), Stasinopoulos, D.M. (author), Rigby, R.A. (author), Terlouw, D.J. (author)
Methods: A weight-for-age database was constructed from pre-existing population-based anthropometric data obtained from household surveys and research groups. It contained data collected between 1995 and 2012 on 1 263 119 individuals (909 368 female, 353 751 male) older than 14 days and younger than 50 years in 64 malaria-endemic countries....
article 2015
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Turner, M.A. (author), Mooij, M.G. (author), Vaes, W.H.J. (author), Windhorst, A.D. (author), Hendrikse, N.H. (author), Knibbe, C.A.J. (author), Körgvee, L.T. (author), Maruszak, W. (author), Grynkiewicz, G. (author), Garner, R.C. (author), Tibbocl, D. (author), Park, B.K. (author), de Wildt, S.N. (author)
Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and scientifîc chaflenges One barrier to the evaluation of medicines for children is a lack of Innovative methodologies that have been adapted to the needs of chiIdren This article presents our...
article 2015
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van Dommelen, P. (author), Verkerk, P.H. (author), van Straaten, H.L. (author)
Objective To gain insight into health and related costs associated with very preterm births, one needs accurate information about the prevalence of the disabling conditions, including neonatal hearing loss (NHL). Study design We assessed the prevalence of NHL by week of gestation and categories of birth weight in very preterm neonates. Results...
article 2015
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Zwaveling-Soonawala, N. (author), Trotsenburg, A.S. (author), Verkerk, P.H. (author)
Congenital hypothyroidism (CH) may be of thyroidal (CHT) or central origin (CHC). Worldwide, most neonatal screening programs are TSH based and effectively detect CHT. Only a few screening programs measure total or free T4 and TSH simultaneously or stepwise, enabling detection of CHT as well as CHC. A frequently used argument against screening...
article 2015
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van Dommelen, P. (author), Deurloo, J.A. (author), Gooskens, R.H. (author), Verkerk, P.H. (author)
Background Increased head circumference is often the first and main sign leading to the diagnosis of hydrocephalus. Our aim is to investigate the diagnostic accuracy of referral criteria for head circumference to detect hydrocephalus in the first year of life. Methods A reference group with longitudinal head circumference data (n = 1938) was...
article 2015
Searched for: subject:"Infant"
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