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Bosgra, S. (author), Westerhout, J. (author)In the EU collaborative project ChemScreen an alternative, in vitro assay-based test strategy was developed to screen compounds for reproductive toxicity. A toxicokinetic modeling approach was used to allow quantitative comparison between effective concentrations in the in vitro test battery and observations of developmental toxicity in vivo....article 2015
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Masthoff, L.J. (author), Hoff, R. (author), Verhoeckx, K.C.M. (author), van Os-Medendorp, H. (author), Michelsen-Huisman, A. (author), Baumert, J.L. (author), Pasmans, S.G. (author), Meijer, Y. (author), Knulst, A.C. (author)Background Allergenicity of foods can be influenced by processing. Tree nuts are an important source of nutrition and increasingly consumed; however, processing methods are quite variable and data are currently lacking on the effects of processing on allergenicity. Objective To perform a systematic literature review on the effects of food...article 2013
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Punt, A. (author), Schiffelers, M.J.W.A. (author), Jean Horbach, G. (author), van de Sandt, J.J.M. (author), Groothuis, G.M.M. (author), Rietjens, I.M.C.M. (author), Blaauboer, B.J. (author)The present paper aims at identifying strategies to increase the impact and applicability of alternative testing strategies in risk assessment. To this end, a quantitative and qualitative literature evaluation was performed on (a) current research efforts in the development of in vitro methods aiming for alternatives to animal testing, (b) the...article 2011
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Scott, L. (author), Eskes, C. (author), Hoffmann, S. (author), Adriaens, E. (author), Alepée, N. (author), Bufo, M. (author), Clothier, R. (author), Facchini, D. (author), Faller, C. (author), Guest, R. (author), Harbell, J. (author), Hartung, T. (author), Kamp, H. (author), Varlet, B.L. (author), Meloni, M. (author), McNamee, P. (author), Osborne, R. (author), Pape, W. (author), Pfannenbecker, U. (author), Prinsen, M. (author), Seaman, C. (author), Spielmann, H. (author), Stokes, W. (author), Trouba, K. (author), Berghe, C.V.d. (author), Goethem, F.V. (author), Vassallo, M. (author), Vinardell, P. (author), Zuang, V. (author), TNO Kwaliteit van Leven (author)In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a full regulatory replacement for the Draize Eye Irritation test. However, companies have been using in vitro methods to screen new formulations and in some cases as their primary assessment of eye irritation potential for many years. The present...article 2010
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Schutte, K. (author), Prinsen, M.K. (author), McNamee, P.M. (author), Roggeband, R. (author), TNO Kwaliteit van Leven (author)Eye irritation is an important endpoint in the safety evaluation of consumer products and their ingredients. Several in vitro methods have been developed and are used by different industry sectors to assess eye irritation. One such in vitro method in use for some time already is the isolated chicken eye test (ICE). This investigation focuses on...article 2009