A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo

Towards human ex vivo organ perfusion models to elucidate drug pharmacokinetics in health and disease

Setting the stage for next-generation risk assessment with non-animal approaches the EU-ToxRisk project experience

COST Action 'ImpARAS': What have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium

The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST

Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity) from new or modified dietary proteins

Evaluating in vitro-in vivo extrapolation of toxicokinetics

Reversal of visceral hypersensitivity in rat by Menthacarin®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation

Comparison of in vitro assays in selecting radiotracers for in vivo P-glycoprotein PET imaging

An integrative test strategy for cancer hazard identification

Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo

Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP)

Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics

Quantitation of ortho-cresyl phosphate adducts to butyrylcholinesterase in human serum by immunomagnetic-UHPLC-MS/MS

Bioavailability and biodistribution of differently charged polystyrene nanoparticles upon oral exposure in rats

Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models

Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context

To pool or not to pool? Impact of the use of individual and pooled fecal samples for in vitro fermentation studies

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.

In vitro models for the prediction of in vivo performance of oral dosage forms