Searched for: subject%3A%22Immunotoxicity%22
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Ruehl-Fehlert, C. (author), Parker, G.A. (author), Elmore, S.A. (author), Kuper, C.F. (author)
Cells of the immune system are found in every organ, from the classic lymphoid organs to tissues such as liver, mucosae, and omental adipose tissue. Toxicity to the immune system may be from a direct or indirect injury to lymphoid organs. The morphological responses range from lymphocyte depletion to proliferation, and may result in an increased...
bookPart 2017
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Kemmerling, J. (author), Fehlert, E. (author), Kuper, C.F. (author), Rühl-Fehlert, C. (author), Stropp, G. (author), Vogels, J. (author), Krul, C. (author), Vohr, H.W. (author)
Exposure to chemicals may have an influence on the immune system. Often, this is an unwanted effect but in some pharmaceuticals, it is the intended mechanism of action. Immune function tests and in depth histopathological investigations of immune organs were integrated in rodent toxicity studies performed according to an extended OECD test...
article 2015
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Schmeits, P.C.J. (author), Schaap, M.M. (author), Luijten, M. (author), van Someren, E. (author), Boorsma, A. (author), van Loveren, H. (author), Peijnenburg, A.A.C.M. (author), Hendriksen, P.J.M. (author)
Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and study type (in vitro or in vivo). To acquire more insight into this, we assessed the transcriptomic...
article 2015
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Bodin, J. (author), Kocbach Bølling, A. (author), Wendt, A. (author), Eliasson, L. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)
Type 1 diabetes mellitus (T1DM) is an autoimmune destruction of insulin producing pancreatic beta-cells due to a genetic predisposition and can be triggered by environmental factors. We have previously shown that bisphenol A (BPA) accelerates the spontaneous development of diabetes in non-obese diabetic (NOD) mice. Here, we hypothesized that...
article 2015
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Bodin, J. (author), Bølling, A.B. (author), Becher, R. (author), Kuper, F. (author), Løvik, M. (author), Nygaard, U.C. (author)
Diabetes mellitus type 1 is an autoimmune disease with a genetic predisposition that is triggered by environmental factors during early life. Epidemiological studies show that bisphenol A (BPA), an endocrine disruptor, has been detected in about 90% of all analyzed human urine samples. In this study, BPA was found to increase the severity of...
article 2014
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Wolterbeek, A.P.M. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Piersma, A.H. (author), van Loveren, H. (author)
The susceptibility of developing immune system to chemical disruption warrants the assessment of immune parameters in reproductive and developmental testing protocols. In this study, a wide range of immune endpoints was included in an extended one-generation reproduction toxicity study (EOGRTS) design to determine the relative sensitivity of...
article 2013
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van Mierlo, G.J.D. (author), Kuper, C.F. (author), de Zeeuw-Brouwer, M.L. (author), Schijf, M.A. (author), Bruijntjes, J.P. (author), Otto, M. (author), Ganderup, N.C. (author), Penninks, A.H. (author)
Introduction: There is a growing interest in the minipig as a non-rodent species in the safety assessment of (bio) pharmaceuticals and (agro) chemicals. For (bio) pharmaceuticals the need to evaluate the potential adverse effects on the immune system is an increasingly important aspect of safety evaluation. In the present study, cyclosporin A...
article 2013
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Menke, A. (author), Wolterbeek, A. (author), Snel, C. (author), Bruijntjes, J. (author), Groot, D.D. (author), Oostrum, L.V. (author), Waalkens, I. (author), Kuper, C.F. (author)
Characteristic susceptibility to environmental and pharmaceutical exposure may occur during periods in life of marked histophysiological changes of the immune system. Perinatal development is such a period; pregnancy followed by lactation is potentially another one. Here, we explored the influence of pregnancy and lactation on the model...
article 2012
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens-Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Piersma, A.H. (author), van Loveren, H. (author)
Developmental immunotoxicity assessment is considered ready for inclusion in developmental toxicity studies. Further evaluation of proposed and additional assays is needed to determine their utility in assessing developmental immunotoxicity. In this study, a wide range of immunological parameters was included in an extended one-generation...
article 2011
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Zuurmond, A.M. (author), Koudijs, A. (author), van El, B. (author), Doornbos, R.P. (author), van Manen-Vernooij, B.C.T. (author), Bastiaans, J.H.M.W. (author), Penninks, A.H. (author), van Bilsen, J.H.M. (author), Cnubben, N.H.P. (author), de Groot, J. (author)
Pharmacokinetic properties and safety profile of a drug are likely influenced by the disease state of a patient. In this study, we investigated the influence of arthritic processes on pharmacokinetics and immunotoxicity of interleukin-1 receptor antagonist (Anakinra) in the rat adjuvant arthritis model. Anakinra dose-dependently suppressed joint...
article 2011
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Tonk, E.C.M. (author), de Groot, D.M.G. (author), Penninks, A.H. (author), Waalkens - Berendsen, I.D.H. (author), Wolterbeek, A.P.M. (author), Slob, W. (author), Piersma, A.H. (author), van Loveren, H. (author), TNO Kwaliteit van Leven (author)
Current developmental and reproductive toxicity protocols include only a limited set of parameters for effects on the developing immune system. In this study, a wide range of immunological parameters were included in a pre- and postnatal developmental toxicity study. Dose-response data were compared to determine the relative sensitivity of...
article 2010
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Janssen, G.B. (author), Penninks, A.H. (author), Knippels, L.M.J. (author), van Zijverden, M. (author), Spanhaak, S. (author), TNO Kwaliteit van Leven (author)
This paper describes studies performed with ERA-63 a low molecular weight pharmaceutical with intended immunomodulatory effects. Since this compound was also known to have estrogenic activity a non-conventional approach was taken in order to differentiate between estrogenic and non-estrogenic-induced immunomodulatory effects. EE was included not...
article 2008
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Kuper, C.F. (author), van Zijverden, M. (author), Klaassen, C. (author), Tegelenbosch-Schouten, M. (author), Wolterbeek, A.P.M. (author), TNO Kwaliteit van Leven (author)
The effects of cyclosporin A (CY) and cyclophosphamide (CPS) on Peyer's patches (PP) were studied in Wistar rats, exposed in utero and neonatally or during adult age. In one study, pregnant dams received 5 or 15 mg/kg bw/day CY from gestation day 6 to day 21 of lactation. In two other studies, animals were exposed at young adult age: female rats...
article 2007
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Frieke Kuper, C. (author), TNO Kwaliteit van Leven (author)
Histologic examination of lymphoid organs has revealed immunotoxic effects of a broad range of substances. The thymus has proven especially sensitive. The relative lack of sensitivity of mucosa-associated lymphoid cells and tissues may be due to shortcomings in the way they are examined. Validation of ways to examine mucosal lymphoid tissues and...
article 2006
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Germolec, D.R. (author), Kashon, M. (author), Nyska, A. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)
The accuracy of extended histopathology to detect immunotoxic chemicals in female B6C3F1 mice was evaluated under the auspices of the National Toxicology Program (NTP). A workgroup was formed consisting of four pathologists who conducted extended histopathological evaluation of lymphoid tissues obtained from a subset of NTP toxicology studies,...
article 2004
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Germolec, D.R. (author), Nyska, A. (author), Kashon, M. (author), Kuper, C.F. (author), Portier, C. (author), Kommineni, C. (author), Johnson, K.A. (author), Luster, M.I. (author), TNO Voeding (author)
There has been considerable interest in the use of expanded histopathology as a primary screen for immunotoxicity assessment. To determine the utility of a semiquantitative histopathology approach for examining specific structural and architectural changes in lymphoid tissues, a validation effort was initiated. This study addresses the...
article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Vos, J.G. (author), Kuper, C.F. (author)
Toxicological pathology of lymphoid organs plays an important role in the risk assessment process of immunotoxicants. Identification of chemicals that have the potential to cause injury to the immune system is of considerable public health significance because of the role of the immune system in infectious diseases, hypersensitivity reactions...
article 2004
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Kuper, C.F. (author), Arts, J.H.E. (author), Feron, V.J. (author), TNO Voeding (author)
The mucosal membranes form a weak mechanical barrier, but they are provided with an extensive specific and non-specific defence system. Antigenic stimulation of the mucosal immune system of the oronasal passages induces specific, local immune responses, and activates immune components of mucosae elsewhere as well as the systemic immune system....
article 2003
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Jonker, D. (author), Lina, B.A.R. (author), Kozianowski, G. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)
The potential subchronic oral toxicity of isomaltulose (Palatinose®) was examined by administering this substance in the diet to groups of 20 male and 20 female Wistar rats at levels of 0, 2.5, 5 and 10% for 13 consecutive weeks. Daily clinical observations, body weight, food conversion efficiency, food and water consumption were not affected at...
article 2002
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Kuper, C.F. (author), Harleman, J.H. (author), Richter-Reichelm, H.B. (author), Vos, J.G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Toxicologic pathology is crucial in the identification and characterization of health effects following exposure to xenobiotics, mainly in toxicity experiments in rodents. Regarding regulatory toxicology, histopathology of lymphoid organs and tissues is a cornerstone in the identification of immunotoxic compounds. A 2-tier testing system is...
article 2000
Searched for: subject%3A%22Immunotoxicity%22
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