Onderkoeling

Heat strain and gross efficiency during endurance exercise after lower, upper, or whole body precooling in the heat

The maximal power that muscles can generate is reduced at low muscle temperatures. However, in prolonged heavy exercise in the heat, a high core temperature may be the factor limiting performance. Precooling has been shown to delay the attainment of hyperthermia. It is still unclear if the whole body should be cooled or if the active muscles...

Finger cold-induced vasodilation: A review

Cold-induced vasodilation (CIVD) in the finger tips generally occurs 5-10 min after the start of local cold exposure of the extremities. This phenomenon is believed to reduce the risk of local cold injuries. However, CIVD is almost absent during hypothermia, when survival of the organism takes precedence over the survival of peripheral tissue....

Finger cold-induced vasodilatation during hypothermia, hyperthermia and at thermoneutrality

BACKGROUND: Exposure of the fingers to severe cold leads to cold-induced vasodilation (CIVD). The influence of ambient temperature on the CIVD-response is well understood and documented, but the response of CIVD to hyperthermia and mild hypothermia has rarely been investigated. METHODS: To investigate the influence of body thermal status on the...

Influence of single and multiple doses of amifostine on the efficacy and the pharmacokinetics of carboplatin in mice

We have previously reported that amifostine potentiates the anti-tumour activity of carboplatin in mice. The present study was carried out in well-established human ovarian cancer xenografts OVCAR-3, A2780 and FMa grown subcutaneously in the nude mouse. It was found that a single dose of amifostine resulted in a higher increase in the anti...

Comparison of four noninvasive rewarming methods for mild hypothermia

Four noninvasive rewarming techniques for mildly hypothermic subjects were compared. Seven subjects were cooled in a water bath of 15°C for 2 h to an average esophageal temperature (Tes) of 36°C. Thereafter, the subjects were rewarmed by immersion of the body in a water bath of 42°C (Method 1), the body but not the extremities in water of 42°C ...