A moderate elevation of blood glucose level increases the effectiveness of thermoradiotherapy in a rat tumor model. I. Relative contributions of glucose and heating to tumor acidification

A moderate elevation of blood glucose level increases the effectiveness of thermoradiotherapy in a rat tumor model. II. Improved tumor control at clinically achievable temperatures

Purpose: To assess the therapeutic gain (at the TCD50 level) that can be obtained by boosting thermoradiotherapy with intravenous glucose infusion at different temperatures. This completes our series of studies to determine the optimal conditions and the effectiveness of glucose administration at clinically achievable glucose levels and...

Finger cold-induced vasodilatation during hypothermia, hyperthermia and at thermoneutrality

BACKGROUND: Exposure of the fingers to severe cold leads to cold-induced vasodilation (CIVD). The influence of ambient temperature on the CIVD-response is well understood and documented, but the response of CIVD to hyperthermia and mild hypothermia has rarely been investigated. METHODS: To investigate the influence of body thermal status on the...