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Pletsa, V. (author), Steenwinkel, M.-J.S.T. (author), van Delft, J.H.M. (author), Baan, R.A. (author), Kyrtopoulos, S.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Following single or multiple oral treatments of rats or λlacZ transgenic mice with methyl bromide, methylated DNA adducts (N7- and/or O6-methylguanine) were found at comparable levels in various tissues, including among others the glandular stomach, the forestomach and the liver. Multiple rat treatment resulted in substantial decreases in the...article 1998
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de Vreede, J.A.F. (author), den Boeft, J. (author), van Hemmen, J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In agricultural areas where greenhouses and dwellings are intermixed, the general population as well as the professional applicators may be exposed to pesticides. In a field study on Crete, exposure to methyl bromide during soil fumigation was assessed. Exposure of applicators (both contractors and farmers) were measured with personal air...article 1998
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Sherratt, P.J. (author), Manson, M.M. (author), Thomson, A.M. (author), Hissink, E.A.M. (author), Neal, G.E. (author), van Bladeren, P.J. (author), Green, T. (author), Hayes, J.D. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A characteristic feature of the class Theta glutathione S-transferase (GST) T1-1 is its ability to activate dichloromethane and dibromoethane by catalysing the formation of mutagenic conjugates. The level of the GSTT1 subunit within tissues is an important determinant of susceptibility to the carcinogenic effects of these dihaloalkanes. In the...article 1998