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Stam, J. (author), Karsdorp, I. (author)
Veel criminele incidenten, zoals drugsproductie en wapenopslag, vinden plaats in sociale huurwoningen. De huurders van deze woningen zijn vaak geronseld door criminelen. Deze gebruiken de woningen; de huurders − katvangers zoals ze worden genoemd − zijn op papier aansprakelijk. Deze katvangers worden gekenmerkt door verschillende...
article 2022
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Pinart, M. (author), Dötsch, A. (author), Schlicht, K. (author), Laudes, M. (author), Bouwman, J. (author), Forslund, S.F. (author), Pischon, T. (author), Nimptsch, K. (author)
Whether the gut microbiome in obesity is characterized by lower diversity and altered composition at the phylum or genus level may be more accurately investigated using high-through-put sequencing technologies. We conducted a systematic review in PubMed and Embase including 32 cross-sectional studies assessing the gut microbiome composition by...
article 2022
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Schadd, M.P.D. (author), Schoonderwoerd, T.A.J. (author), van den Bosch, K. (author), Visker, O.H. (author), Haije, T. (author), Veltman, K.H.J. (author)
The rapid progress in artificial intelligence enables technology to more and more become a partner of humans in a team, rather than being a tool. Even more than in human teams, partners of human–agent teams have different strengths and weaknesses, and they must acknowledge and utilize their respective capabilities. Coordinated team collaboration...
article 2022
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Ostendorf, R. (author), Erpelinck, S. (author)
The Organ-on-a-Chip Early Research Program enables TNO to offer state-of-the-art technologies that help the pharmaceutical industry advance drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model human tissue functioning and accelerate compound development and testing. The Intestinal Epithelial Barrier...
other 2022
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Ostendorf, R. (author)
The Organ-on-a-Chip Early Research Program (ERP) has enabled TNO to offer a number of state-of-the-art technologies to help pharmaceutical and biotech companies advance and accelerate drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model the workings of human tissue and accelerate compound development...
other 2022
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Kox, E.S. (author), Siegling, L. (author), Kerstholt, J.H. (author)
Autonomous agents (AA) will increasingly be deployed as teammates instead of tools. In many operational situations, flawless performance from AA cannot be guaranteed. This may lead to a breach in the human’s trust, which can compromise collaboration. This highlights the importance of thinking about how to deal with error and trust violations...
article 2022
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de Graaf, M.M.A. (author), Perugia, G. (author), Fosch-Villaronga, E. (author), Schaertl Short, E. (author), Lim, A. (author), Broz, F. (author), Neerincx, M. (author)
Discrimination and bias are pressing issues of many AI and robotics applications. These outcomes may derive from limited datasets that do not fully represent society as a whole or from the AI scientific community’s western-male configuration bias. Although being a pressing issue, understanding how robotic systems can replicate and amplify...
conference paper 2022
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Schoonderwoerd, T.A.J. (author), van Zoelen, E.M. (author), van den Bosch, K. (author), Neerincx, M.A. (author)
The rapid advancement of technology empowered by artificial intelligence is believed to intensify the collaboration between humans and AI as team partners. Successful collaboration requires partners to learn about each other and about the task. This human-AI co-learning can be achieved by presenting situations that enable partners to share...
article 2022
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Pronk, A. (author), Loh, M. (author), Kuijpers, E. (author), Albin, M. (author), Selander, J. (author), Godderis, L. (author), Ghosh, M. (author), Vermeulen, R. (author), Peters, S. (author), Sivesind Mehlum, I. (author), Turner, M. (author), Schlunssen, V. (author), Goldberg, M. (author), Kogevinas, M. (author), Harding, B. (author), Solovieva, S. (author), Garani-Papadatos, T. (author), van Tongeren, M. (author), Stierum, R. (author)
Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all...
article 2022
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Michielsen, C.C.J.R. (author), Hangelbroek, R.W.J. (author), Bragt, M.C.E. (author), Verheij, E.R. (author), Wopereis, S. (author), Mensink, R.P. (author), Afman, L.A. (author)
Scope: The drug fenofibrate and dietary fish oils can effectively lower circulating triglyceride (TG) concentrations. However, a detailed comparative analysis of the effects on the plasma metabolome is missing. Methods and Results: Twenty overweight and obese subjects participate in a double-blind, cross-over intervention trial and receive in a...
article 2022
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Bongers, C.C.W.G. (author), de Korte, J.Q. (author), Zwartkruis, M. (author), Levels, K. (author), Kingma, B.R.M. (author), Eijsvogels, T.M.H. (author)
The combination of an exacerbated workload and impermeable nature of the personal protective equipment (PPE) worn by COVID-19 healthcare workers increases heat strain. We aimed to compare the prevalence of heat strain symptoms before (routine care without PPE) versus during the COVID-19 pandemic (COVID-19 care with PPE), identify risk factors...
article 2022
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Terluin, B. (author), Eekhout, I. (author), Terwee, C.B. (author)
Objectives: The anchor-based minimal important change (MIC), based on the receiver operating characteristic (ROC) analysis or predictive modeling, is biased by the proportion of improved patients. The adjusted MIC, published in 2017, adjusts the predictive MIC for this bias but does not take the reliability of the transition ratings (i.e., the...
article 2022
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Komninos, D. (author), Ramos, L. (author), van der Heijden, G.W. (author), Morrison, M.C. (author), Kleemann, R. (author), van Herwaarden, A.E. (author), Kiliaan, A.J. (author), Arnoldussen, I.A.C. (author)
Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr−/−.Leiden) mice, and studied...
article 2022
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Regeer, H. (author), van Empelen, P. (author), Bilo, H.J.G. (author), de Koning, E.J.P. (author), Huisman, S.D. (author)
Objective. To examine the relationship between risk factors for low patient activation and change in patient activation, well-being, and health outcomes in people with type 2 diabetes mellitus (T2DM). Method. A longitudinal prospective study was conducted with measurements at baseline and 20-week follow-up among 603 people with T2DM...
article 2022
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Kamphorst, B. (author), Rooijakkers, T. (author), Veugen, T. (author), Cellamare, M. (author), Knoors, D. (author)
article 2022
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Klous, L. (author), van Diemen, F. (author), Ruijs, S. (author), Gerrett, N. (author), Daanen, H. (author), de Weerd, M. (author), Veenstra, B. (author), Levels, K. (author)
Purpose: Three feasible cooling methods for treatment of hyperthermic individuals in the military, that differed considerably in water volume needed (none to ~80 L), were evaluated. Methods: Ten male soldiers were cooled following exercise-induced hyperthermia (rectal temperature (Tre) ∼39.5 °C) using ventilation by fanning (1.7 m s−1),...
article 2022
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Schraagen, J.M. (author), Barnhoorn, J.S. (author), van Schendel, J. (author), van Vught, W. (author)
Multi-level human-autonomy teaming in a distributed mission context consists of multiple manned and unmanned systems that require flexible decision making authority. We introduce the notion of ‘hybrid multi-team systems’ to refer to multiple teams consisting of n-number of humans and n-number of semi-autonomous agents having interdependence...
article 2022
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)
Background. Our aim was to develop a machine learning model, using real-world data captured from a connected auto-injector device and from early indicators from the first 3 months of treatment, to predict sub-optimal adherence to recombinant human growth hormone (r-hGH) in patients with growth disorders. Methods. Adherence to r-hGH treatment was...
article 2022
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Pupa, A. (author), van Dijk, W. (author), Brekelmans, C. (author), Secchis, C. (author)
Effective task scheduling in human-robot collaboration (HRC) scenarios is one of the great challenges of collaborative robotics. The shared workspace inside an industrial setting brings a lot of uncertainties that cannot be foreseen. A prior offline task scheduling strategy is ineffective in dealing with these uncertainties. In this paper, a...
article 2022
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Gart, E. (author), Salic, K. (author), Morrison, M.C. (author), Giera, M. (author), Attema, J. (author), de Ruiter, C. (author), Caspers, M.P.M. (author), Schuren, F. (author), Bobeldijk-Pastorova, I. (author), Heer, M. (author), Qin, Y. (author), Kleemann, R. (author)
Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that is associated with gut dysbiosis, enhanced gut permeability, adiposity and insulin resistance. Prebiotics such as human milk oligosaccharide 2'-fucosyllactose are thought to primarily improve gut health and it is uncertain whether they would affect more distant...
article 2022
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