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van Dommelen, P. (author), Barios, R.M. (author), Arnaud, L. (author), le Masne, Q. (author), Koledova, E. (author)Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March...article 2023
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van Dommelen, P. (author), Arnaud, L. (author), Koledova, E.B. (author)Curve matching may be used to predict growth outcomes using data of patients whose growth curves resemble those of a new patient with growth hormone deficiency (GHD) and those born small for gestational age (SGA). We aimed to investigate the validity of curve matching to predict growth in patients with GHD and those born SGA receiving...article 2022
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The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasisSchutte, M.H. (author), Kleemann, R. (author), Nota, N.M. (author), Wiepjes, C.M. (author), Snabel, J.M. (author), T'Sjoen, G. (author), Thijs, A. (author), den Heijer, M. (author)Background: Cardiovascular risk is increased in transgender persons using gender-affirming hormone therapy. To gain insight into the mechanism by which sex hormones affect cardiovascular risk in transgender persons, we investigated the effect of hormone therapy on markers of inflammation and hemostasis. Methods: In this exploratory study, 48...article 2022
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background. Our aim was to develop a machine learning model, using real-world data captured from a connected auto-injector device and from early indicators from the first 3 months of treatment, to predict sub-optimal adherence to recombinant human growth hormone (r-hGH) in patients with growth disorders. Methods. Adherence to r-hGH treatment was...article 2022
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Morgan, K. (author), van Dommelen, P. (author), Batista, A.R. (author), Koledova, E. (author)We explored whether a multi-component approach - using a digital health device, the easypod™ auto-injector, the 'MySupport' patient support programme (PSP) and a Patient Activation Measure® (PAM®) - could improve adherence in patients receiving recombinant human growth hormone (r-hGH). A 13-item PAM was used to assess caregiver self-reported...bookPart 2022
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Tornincasa, V. (author), Dixon, V. (author), Le Masne, Q. (author), Martin, B. (author), Arnaud, L. (author), van Dommelen, P. (author), Koledova, E. (author)Digital health has seen rapid advancements over the last few years in helping patients and their healthcare professionals better manage treatment for a variety of illnesses, including growth hormone (GH) therapy for growth disorders in children and adolescents. For children and adolescents requiring such therapy, as well as for their parents,...article 2022
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Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)Correction to: Arch Toxicol (2014) 88:2261–2287 https://doi.org/10.1007/s00204-014-1400-x.article 2022
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Assefi, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Otero, C. (author), Fernandez-Luque, L. (author), Koledova, E. (author), Calliari, L.E. (author)Background: Recombinant human growth hormone (rhGH) therapy is an effective treatment for children with growth disorders. However, poor outcomes are often associated with suboptimal adherence to treatment. Objective: The easypod connected injection device records and transmits injection settings and dose data from patients receiving rhGH. In...article 2022
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- van Dommelen, P. (author) public lecture 2021
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background: Long-term persistence of use and starting at the earliest possible age are associated with attainment of near-normal adult or final height in children who are treated with growth hormone therapy. However, there are many factors associated with a lack of persistence. Our aim was to study persistence of use in children with growth...article 2021
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Wit, J.M. (author), Sas, T.C.J. (author), Ranke, M.B. (author), van Dommelen, P. (author)Background/aims: We hypothesized that modelling catch-up growth (CUG) as developed for coeliac disease (CD), might also fit CUG in adequately treated children with juvenile hypothyroidism (JHT) or growth hormone deficiency (GHD). Methods: We used a monomolecular function for all available prepubertal data on height SDS minus target height SDS ...article 2021
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background: Suboptimal adherence to recombinant human growth hormone (r-hGH) treatment can lead to suboptimal clinical outcomes. Being able to identify children who are at risk of suboptimal adherence in the near future, and take adequate measures to support adherence, may maximize clinical outcomes. Our aim was to develop a model based on data...article 2021
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Araujo, M. (author), van Dommelen, P. (author), Srivastava, J. (author), Koledova, E. (author)Recombinant human growth hormone (r-hGH) is an established therapy for growth hormone deficiency (GHD); yet, some patients fail to achieve their full height potential, with poor adherence and persistence with the prescribed regimen often a contributing factor. A data-driven clinical decision support system based on “traffic light” visualizations...article 2021
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Araujo, M. (author), van Dommelen, P. (author), Koledova, E.B. (author), Srivastava, J. (author)The problem of consistent therapy adherence is a current challenge for health informatics, and its solution can increase the success rate of treatments. Here we show a methodology to predict, at individual-level, future therapy adherence for patients receiving daily injections of growth hormone (GH) therapy for GH deficiency. Our proposed model...article 2021
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Koledova, E. (author), Tornincasa, V. (author), van Dommelen, P. (author)Background. Poor adherence to long-term recombinant human growth hormone (r-hGH) treatment can lead to suboptimal clinical outcomes; consequently, supporting and monitoring adherence is a crucial part of patient management. We assessed adherence to r-hGH treatment in children with growth disorders over 48 months using a connected monitoring...article 2020
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Zwaveling-Soonawala, N. (author), Trotsenburg, A.S. (author), Verkerk, P.H. (author)Context. In central hypothyroidism (CeH) free thyroxine (FT4) concentrations are low while TSH concentrations may be low, normal or even slightly elevated due to reduced bioactivity. Congenital CeH (CCeH) may be isolated or part of multiple pituitary hormone deficiency (MPHD). Objective. To test our hypotheses that (1) TSH concentrations have a...article 2018
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van Dommelen, P. (author), Koledova, E. (author), Wit, J.M. (author)Background. Quantifying the association between adherence and the growth response to growth hormone (GH) treatment is hampered by suboptimal methods of measuring adherence, confounders associated with the growth response, and restriction of the outcome parameters to yearly growth velocities. Aim. To investigate the effect of adherence on the two...article 2018
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Schoemaker, M.H. (author), Kleemann, R. (author), Morrison, M.C. (author), Verheij, J. (author), Salic, K. (author), van Tol, E.A.F. (author), Kooistra, T. (author), Wielinga, P.Y. (author)Background: Obesity frequently associates with the development of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. Chronic inflammation in white adipose tissue (WAT) seems to be an important driver of these manifestations. Objective: This study investigated a combination of an extensively hydrolyzed casein (eHC), docosahexaenoic...article 2017
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Binsch, O. (author), van Wietmarschen, H. (author), Buick, F. (author)Optimism and perseverance are 2 important assets for soldiers to be able to perform competently in high-risk environments and to complete complex and stressful tasks. Traditionally, optimism is measured using questionnaires and most frequently in a retrospective manner, for example, after a mission is completed. As such, ability to persevere in...article 2016
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Ripken, D. (author), Hendriks, H.F.J. (author)This chapter describes the use of the porcine ex vivo intestinal segment model. This includes the advantages and disadvantages of the segment model and a detailed description of the isolation and culture as well as the applications of the porcine ex vivo intestinal segment model in practice. Compared to the Ussing chamber (Chap. 24) the porcine...bookPart 2015