Searched for: subject:"Homocysteine"
(1 - 12 of 12)
document
van Vliet, T. (author), Jacobs, R.G.J.M. (author), de Deckere, E. (author), van den Berg, H. (author), de Bree, A. (author), van der Put, N.M.J. (author), TNO Kwaliteit van Leven (author)
Objective: To determine the effect of folic acid, vitamin B6 and B12 fortified spreads on the blood concentrations of these vitamins and homocysteine. Design and setting: A 6-week randomized, double-blinded, placebo-controlled, parallel trial carried out in a clinical research center. Subjects: One hundred and fifty healthy volunteers (50% males...
article 2007
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Smulders, Y.M. (author), Smith, D.E.C. (author), Kok, R.M. (author), Teerlink, T. (author), Gellekink, H. (author), Vaes, W.H.J. (author), Stehouwer, C.D.A. (author), Jakobs, C. (author), TNO Kwaliteit van Leven (author)
Background: Red blood cells (RBCs) represent a storage pool for folate. In contrast to plasma, RBC folate can appear in different biochemical isoforms. So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC folate vitamer distribution. Objective: The purpose of this study is to...
article 2007
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de Jong, R.J. (author), Verwei, M. (author), West, C.E. (author), van Vliet, T. (author), Siebelink, E. (author), van den Berg, H. (author), Castenmiller, J.J.M. (author), TNO Kwaliteit van Leven (author)
Objective: The aim of this study was to investigate whether milk fortified with folic acid enhances the folate status of humans and whether the presence of folate-binding proteins (FBP) in pasteurised milk affects the bioavailability of folic acid from fortified milk. In untreated and pasteurised milk, folate occurs bound to FBP, while FBP is ...
article 2005
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Beulens, J.W.J. (author), Sierksma, A. (author), Schaafsma, G. (author), Kok, F.J. (author), Struys, E.A. (author), Jakobs, C. (author), Hendriks, H.F.J. (author), TNO Kwaliteit van Leven (author)
Background: Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease. Because plasma homocysteine (tHcy) is considered an independent risk factor for cardiovascular disease and associated with alcohol consumption, the authors investigated the effect of moderate alcohol consumption on kinetics of plasma tHcy...
article 2005
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Olthof, M.R. (author), Brink, E.J. (author), Katan, M.B. (author), Verhoef, P. (author), TNO Kwaliteit van Leven (author)
Background: A high homocysteine concentration is a potential risk factor for cardiovascular disease that can be reduced through betaine supplementation. Choline is the precursor for betaine, but the effects of choline supplementation on plasma total homocysteine (tHcy) concentrations in healthy humans are unknown. Objective: The objective was to...
article 2005
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Witte, D.R. (author), Broekmans, W.M.R. (author), Kardinaal, A.F.M. (author), Klöpping-Ketelaars, I.A.A. (author), van Poppel, G. (author), Bots, M.L. (author), Kluft, C. (author), Princen, J.M.G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Background: Flow mediated dilatation (FMD) of the brachial artery and soluble intercellular adhesion molecule 1 (sICAM-1) are measures of distinct functions of the endothelium, reflecting nitric oxide (NO)-mediated and pro-inflammatory status, respectively. The comparative value of the two measures in relation to cardiovascular risk is unknown....
article 2003
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Verhoef, P. (author), Pasman, W.J. (author), van Vliet, T. (author), Urgert, R. (author), Katan, M.B. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
Background: A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown. Objective: The objective was to determine whether caffeine explains the...
article 2002
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Vermeulen, E.G.J. (author), Niessen, H.W.M. (author), Bogels, M. (author), Stehouwer, C.D.A. (author), Rauwerda, J.A. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)
The aim of this study was to determine whether the morphology of the muscular femoral artery in patients with atherosclerosis and hyperhomocysteinemia differs from that of atherosclerotic vessels from patients with normal homocysteine levels. Whole-vessel biopsies of the superficial femoral artery were taken from patients with symptomatic...
article 2001
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van der Gaag, M.S. (author), Ubbink, J.B. (author), Sillanaukee, P. (author), Nikkari, S. (author), Hendriks, H.F.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Serum homocysteine increases after moderate consumption of red wine and spirits, but not after moderate consumption of beer. Vitamin B6 in beer seems to prevent the alcohol-induced rise in serum homocysteine. Chemicals/CAS: Homocysteine, 454-28-4; Pyridoxine, 65-23-6
article 2000
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Becker, A. (author), van Hinsbergh, V.W.M. (author), Kostense, P.J. (author), Jager, A. (author), Dekker, J.M. (author), Nijpels, G. (author), Heine, R.J. (author), Bouter, L.M. (author), Stehouwer, C.D.A. (author), TNO Preventie en Gezondheid (author)
Background: Hyperhomocysteinaemia may constitute an independent risk factor for cardiovascular disease, but it is still unclear by which pathophysiological mechanisms homocysteine (tHcy) may promote atherothrombosis. The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of...
article 2000
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Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Schuurman, C.R.W.C. (author), Verhagen, H. (author), van den Berg, H. (author), Kok, F.J. (author), van Poppel, G. (author), TNO Voeding (author)
Observational epidemiologic studies have shown that a high consumption of fruits and vegetables is associated with a decreased risk of chronic diseases. Little is known about the bioavailability of constituents from vegetables and fruits and the effect of these constituents on markers for disease risk. Currently, the recommendation is to...
article 2000
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de Jong, S.C. (author), Stehouwer, C.D.A. (author), van den Berg, M. (author), Vischer, U.M. (author), Rauwerda, J.A. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
Hyperhomocysteinemia is associated with severe, premature atherosclerosis and thromboembolism. The mechanisms involved in the atherogenic and thrombotic complications of hyperhomocysteinemia are not understood. It has been suggested that hyperhomocysteinemia predisposes to atherosclerosis by injuring the vascular endothelium. Whether...
article 1997
Searched for: subject:"Homocysteine"
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