Degenerated and healthy cartilage are equally vulnerable to blood-induced damage

Background: Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability. Objective: To examine the hypothesis that because degenerated cartilage has a limited repair capacity, it is more susceptible than healthy cartilage to blood-induced cartilage damage. Methods: Healthy,...

Blood-induced joint damage: A canine in vivo study

Objective. To investigate the direct and indirect (via synovial inflammation) effects of intraarticular bleeding on cartilage in vivo. Methods. Right knees of 14 beagle dogs were injected with autologous blood on days 0 and 2. Cartilage matrix proteoglycan turnover, collagen damage, and synovial inflammation of these knees, including the...