Searched for: subject%3A%22Helper%255C%2BCell%22
(1 - 6 of 6)
document
Harb, H. (author), van Tol, E.A.F. (author), Heine, H. (author), Braaksma, M. (author), Gross, G. (author), Overkamp, K. (author), Hennen, M. (author), Alrifai, M. (author), Conrad, M.L. (author), Renz, H. (author), Garn, H. (author)
Background: Oral supplementation with probiotic bacteria can protect against the development of allergic and inflammatory diseases. Objective: The aim of this study was to investigate potential immunomodulatory and allergy-protective effects of processed Lactobacillus rhamnosus GG (LGG)-derived supernatants early in life in neonatal mice....
article 2013
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de Jong, E.C. (author), Spanhaak, S. (author), Martens, B.P.M. (author), Kapsenberg, M.L. (author), Penninks, A.H. (author), Wierenga, E.A. (author), TNO Voeding (author)
Background: Increasing evidence indicates a prominent role of allergen-specific TH2 cells, with high IL-4 and IL-5 production and low interferon-γ production, in the regulation of IgE and eosinophil production in allergic disorders. However, most studies have concentrated on T cells reactive with inhalation allergens, whereas little is known...
article 1996
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Foy, T.M. (author), Laman, J.D. (author), Ledbetter, J.A. (author), Aruffo, A. (author), Claassen, E. (author), Noelle, R.J. (author), Medisch Biologisch Laboratorium TNO (author)
gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T-dependent (TD) antigens. Treatment of mice with anti-gp39 in vivo inhibits both primary and secondary antibody formation to TD, but not T-independent antigens. However, the role of this receptor-ligand pair in the...
article 1994
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Nagelkerken, L. (author), Gollob, K.J. (author), Tielemans, M. (author), Coffman, R.L. (author), Gezondheidsorganisatie TNO Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Stimulation of murine CD4+ T cells with staphylococcal enterotoxin B (SEB) results in the preferential development of T helper (Th) 1 cells [i.e. high interferon (IFN)-γ and low interleukin (IL)-4, IL-5 and IL-10]; whereas in response to plate-bound anti-CD3 or anti-T cell receptor-αβ, Th1 as well as Th2 cells develop. In the present study, we...
article 1993
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Lubbe, F.H. (author), Brocades Zaalberg, O. (author), Medisch Biologisch Laboratorium TNO (author)
Helper T cells specific for sheep erythrocytes were generated in lethally irradiated mice. The helper effect exerted by these cells was determined in vitro in spleen cell cultures. Irradiation of the helper cells in vivo or in vitro with 1-9 Gy resulted in a bimodal relation between radiation dose and helper effect when measured either...
article 1982
document
Instituut voor experimentele gerontologie TNO (author), Blankwater, M.J. (author)
A review of the present knowledge of the effect of age on the humoral immune response of mice is presented. It is shown that the capacity to mount an antibody response decreases with age, especially when the immune system is challenged for the first time by low doses of antigen, and when T cells are required for the response. Literature data are...
article 1978
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