- document
-
Selberherr, E. (author), Grau, J.H. (author), Meixner, M. (author), Liere, K. (author), Ercolini, D. (author), de Filippo, C. (author), Caderni, G. (author), Brigidi, P. (author), Turroni, S. (author)The core microbiome, which refers to a set of consistent microbial features across populations, is of major interest in microbiome research and has been addressed by numerous studies. Understanding the core microbiome can help identify elements that lead to dysbiosis, and lead to treatments for microbiome-related health states. However, defining...article 2022
- document
-
Stevens, L.J. (author), Donkers, J.M. (author), Dubbel, J. (author), Vaes, W.H.J. (author), van de Steeg, E. (author), Knibbe, C.A.J. (author), Alwayn, I.P.J. (author), van de Steeg, E. (author)To predict the absorption, distribution, metabolism and excretion (ADME) profile of candidate drugs a variety of preclinical models can be applied. The ADME and toxicological behavior of newly developed drugs are often investigated prior to assessment in humans, which is associated with long time-lines and high costs. Therefore, good predictions...article 2020
- document
-
Schuring, M. (author), Robroek, S.J.W. (author), Carrino, L. (author), O'Prinsen, A.C. (author), Oude Hengel, K.M. (author), Avendano, M. (author), Burdorf, A. (author)Background: Declines in employment protection may have disproportionate effects on employment opportunities of workers with low education and poorer health. This study investigates the impact of changes in employment protection levels on employment rates according to education and health in 23 European countries. Methods: Data were taken from...article 2020
- document
-
Hollanders, J.J. (author), Schaefer, N. (author), van der Pal, S.M. (author), Oosterlaan, J. (author), Rotteveel, J. (author), Finken, M.J.J. (author)Background: Birth weight (BW) is often used as a proxy for gestational age (GA) in studies on preterm birth. Recent findings indicate that, in addition to perinatal outcomes, subjects born very preterm (VP; GA < 32 weeks) differ from those with a very low birth weight (VLBW; BW < 1,500 g) in postnatal growth up to their final height. Objective:...article 2019
- document
-
Hopman-Rock, M. (author), van Hirtum, H. (author), de Vreede, P. (author), Freiberger, E. (author)Background Activities of daily living (ADL) are often used as predictors of health and function in older persons. This systematic review is part of a series initiated by the European Network for Action on Ageing and Physical Activity (EUNAAPA). Aim To assess psychometric properties of ADL instruments for use in older populations. Methods...article 2018
- document
-
Rowen, D. (author), Mulhem, B. (author), Stevens, K. (author), Vermaire, J.H. (author)Objective This article presents the development of the Dutch value set for the Child Health Utility 9D, a pediatric preference-based measure of quality of life that can be used to generate quality-adjusted life-years. Methods A large online survey was conducted using a discrete choice experiment including a duration attribute with adult members...article 2018
- document
-
van den Broek, T.J. (author), Bakker, G.C.M. (author), Rubingh, C.M. (author), Bijlsma, S. (author), Stroeve, J.H.M. (author), van Ommen, B. (author), van Erk, M.J. (author), Wopereis, S. (author)Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of...article 2017
- document
-
Wopereis, S. (author), Stroeve, J.H.M. (author), Stafleu, A. (author), Bakker, G.C.M. (author), Burggraaf, J. (author), van Erk, M.J. (author), Pellis, L. (author), Boessen, R. (author), Kardinaal, A.A.F. (author), van Ommen, B. (author)Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A...article 2017
- document
-
Schelvis, R.M.C. (author), Wiezer, N.M. (author), Blatter, B.M. (author), van Genabeek, J.A.G.M. (author), Oude Hengel, K.M. (author), Bohlneijer, E.T. (author), van der Beek, A.J. (author)Background The importance of process evaluations in examining how and why interventions are (un) successful is increasingly recognized. Process evaluations mainly studied the implementation process and the quality of the implementation (fidelity). However, in adopting this approach for participatory organizational level occupational health...article 2016
- document
-
TNO Kwaliteit van Leven (author), Stroeve, J.H.M. (author), van Wietmarschen, H. (author), Kremer, B.H.A. (author), van Ommen, B. (author), Wopereis, S. (author)Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life challenges. Physiology acts as a well-orchestrated machinery to adapt to the continuously changing environment. We term this adaptive...article 2015
- document
-
de Wind, A. (author), Geuskens, G.A. (author), Ybema, J.F. (author), Blatter, B.M. (author), Burdorf, A. (author), Bongers, P.M. (author), van der Beek, A.J. (author)Objectives This study aimed to investigate the relative contribution of health, job characteristics, skills and knowledge, and social and financial factors to the transition from work to (non-disability) early retirement. Methods Employees aged 59–63 years (N=2317) were selected from the Study on Transitions in Employment, Ability and Motivation...article 2014
- document
-
Uijtdewilligen, L. (author), Singh, A.S. (author), Chinapaw, M.J. (author), Koppes, L.L.J. (author), van Mechelen, W. (author), Twisk, J.W.R. (author)Background: Young adults face radical life changes regarding residence, marriage, family and work that may negatively impact their health behaviours. Therefore, we investigated the associations of the number of daily hassles and life events and their subjective appraisal with physical activity and screen time in young adulthood. Methods: Data...article 2014
- document
-
Simons, M. (author), Koopman, H. (author), Osinga, M. (author)Insulin requirement affects the careers of diabetic professionals who do safety-sensitive jobs. In most cases, insulin-treated individuals are automatically banned from safety-sensitive jobs because the risk of hypoglycaemia is regarded as incompatible with safety. Recent developments—such as diabetes self-management education, self-monitoring...article 2014
- document
-
van Buuren, S. (author), Perenboom, R.J.M. (author)There are very few norms to evaluate and monitor the health and functioning of the elderly. This paper proposes a compact spatial representation of 25 health measurements of European citizens older than 50 years. Data from 44,285 unique individuals were obtained from the EU-wide Survey of Health, Ageing and Retirement in Europe(SHARE) data...article 2014
- document
-
Wagenaar, A.F. (author), Kompier, M.A.J. (author), Houtman, I.L.D. (author), van den Bossche, S.N.J. (author), Taris, T.W. (author)OBJECTIVE:: The healthy worker effect implies that healthy workers go "up" in employment status whereas less healthy workers go "down" into precarious temporary employment or unemployment. These hypotheses were tested during an economic recession, by predicting various upward and downward contract trajectories, based on workers' health status,...article 2012
- document
-
Janssens, A.C.J.W. (author), Henneman, L. (author), Detmar, S.B. (author), Khoury, M.J. (author), Steyerberg, E.W. (author), Eijkemans, M.J.C. (author), Mushkudiani, N. (author), Oostra, B.A. (author), van Duijn, C.M. (author), MacKenbach, J.P. (author)Objective: We investigated the accuracy of self-reported family history for diabetes, hypertension, and overweight against two reference standards: family history based on physician-assessed health status of relatives and on self-reported personal health status of relatives. Study Design and Setting: Subjects were participants from the Erasmus...article 2012
- document
-
van Koppen, E.J. (author), Schweizer, J.J. (author), Csizmadia, C.G.D.S. (author), Krom, Y. (author), Hylkema, H.B. (author), van Geel, A.M. (author), Koopman, H.M. (author), Verloove-Vanhorick, S.P. (author), Mearin, M.L. (author)OBJECTIVE. Mass screening for celiac disease is controversial. The objective of this study was to determine whether detection of childhood celiac disease by mass screening improves long-term health status and health-related quality of life. METHODS.We conducted a prospective 10-year follow-up study of 32 children who were aged 2 to 4 years, had...article 2009
- document
-
Berra, S. (author), Tebé, C. (author), Erhart, M. (author), Ravens-Sieberer, U. (author), Auquier, P. (author), Detmar, S. (author), Herdman, M. (author), Alonso, J. (author), Rajmil, L. (author), TNO Kwaliteit van Leven (author)Objective: To examine the association between use of health care services and health status, sociodemographic, and health care system characteristics in children and adolescents from 11 European countries. Research Design: Cross-sectional surveys in representative samples included using phone or school-based sampling. Subjects: Children and...article 2009
- document
-
Berger, M.A.M. (author), Krul, A. (author), Daanen, H.A.M. (author), TNO Defensie en Veiligheid (author)Finger dexterity tests are generally used to assess performance decrease due to gloves, cold and pathology. It is generally assumed that the OConnor and Purdue Pegboard test yield similar results. In this experiment we compared these two tests for dry conditions without gloves, and for dry and wet conditions with two types of Nytril gloves. In...article 2009
- document
-
TNO Defensie en Veiligheid (author), Simons, M. (author), Maher, D. (author), Stuben, U. (author), Herbert, K. (author)In a Notice of Proposed Amendment, the European Aviation Safety Agency proposes to introduce a Leisure Pilot License (LPL). Holders of a LPL for airplanes will be allowed to fl y single-engine piston airplanes with a maximum takeoff mass of 2000 kg or less, carrying a maximum of three passengers. In this commentary paper, we express signifi cant...article 2009