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Fransman, W. (author), Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author)Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...article 2023
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Bouwhuis, S. (author), Geuskens, G.A. (author), Boot, C.R.L. (author), van der Beek, A.J. (author), Bongers, P.M. (author)Introduction Precarious employment is associated with poor health. Among employees in precarious employment, those with multiple jobs may face additional health risks, e.g. due to combining work schedules and job roles. Our research question is: do differences in health exist between multiple and single job holders in precarious employment?...article 2019
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Remington, B. (author), Broekman, H.C.H. (author), Blom, W.M. (author), Capt, A. (author), Crevel, R.W.R. (author), Dimitrov, I. (author), Faeste, C.K. (author), Fernandez-Canton, R. (author), Giavi, S. (author), Houben, G.F. (author), Glenn, K.C. (author), Madsen, C.B. (author), Kruizinga, A.K. (author), Constable, A. (author)The development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or...article 2018
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Wambaugh, J.F. (author), Hughes, M.F. (author), Ring, C.L. (author), MacMillan, D.K. (author), Ford, J. (author), Fennell, T.R. (author), Black, S.R. (author), Snyder, R.W. (author), Sipes, N.S. (author), Wetmore, B.A. (author), Westerhout, J. (author), Setzer, R.W. (author), Pearce, R.G. (author), Simmons, J.E. (author), Thomas, R.S. (author)Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo...article 2018
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Deziel, N.C. (author), Nuckols, J.R. (author), Jones, R.R. (author), Graubard, B.I. (author), de Roos, A.J. (author), Pronk, A. (author), Gourley, C. (author), Colt, J.S. (author), Ward, M.H. (author)Proximity to facilities emitting polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/F) has been associated with increased risk of non-Hodgkin lymphoma (NHL). There is limited information about whether proximity to industrial sources leads to indoor PCDD/F contamination of homes. We measured carpet dust concentrations (pg/g...article 2017
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van Lettow, B. (author), de Vries, H. (author), Burdorf, A. (author), van Empelen, P. (author)Prototypes (i.e., social images representing perceptions of typical persons engaging in or refraining from certain behaviour) have been shown to explain health-related behaviours. The present meta-analysis quantified the strength of the associations of prototype perceptions with health motivation and behaviour. Specifically, the analysis...article 2016
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Groenesteijn, L. (author), Commissaris, D.A.C.M. (author), van den Berg-Zwetsloot, M. (author), Hiemstra-Van Mastrigt, S. (author)BACKGROUND: Working in an office environment is characterised by physical inactivity and sedentary behaviour. This behaviour contributes to several health risks in the long run. Dynamic workstations which allow people to combine desk activities with physical activity, may contribute to prevention of these health risks. OBJECTIVE: A dynamic...article 2016
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Remoundou, K. (author), Brennan, M. (author), Sacchettini, G. (author), Panzone, L. (author), Butler-Ellis, M.C. (author), Capri, E. (author), Charistou, A. (author), Chaideftou, E. (author), Gerritsen-Ebben, M.G. (author), Machera, K. (author), Spanoghe, P. (author), Glass, R. (author), Marchis, A. (author), Doanngoc, K. (author), Hart, A. (author), Frewer, L.J. (author)The EU Directive on the sustainable use of pesticides (EU128/2009/EC) requires European Member States to develop training activities targeting occupational exposure to pesticides, and communication material aimed at residents and bystanders. Risk perceptions, knowledge and attitudes associated with passive and occupational exposure to pesticide...article 2015
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Hiemstra-van Mastrigt, S. (author), Kamp, I. (author), van Veen, S.A.T. (author), Vink, P. (author), Bosch, T. (author)New technologies have led to an increasingly sedentary lifestyle. Sedentary behaviour is characterised by physical inactivity and is associated with several health risks. This excessive sitting does not only take place in the office or at home, but also during daily commute. Therefore, BMW AG developed an active seating system for the back seat...article 2015
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A primer on the use of cluster analysis or factor analysis to assess co-occurrence of risk behaviorsHofstetter, H. (author), Dusseldorp, E. (author), van Empelen, P. (author), Paulussen, T.W.G.M. (author)Objective: The aim of this paper is to provide a guideline to a universal understanding of the analysis of co-occurrence of risk behaviors. The use of cluster analysis and factor analysis was clarified. Method: A theoretical introduction to cluster analysis and factor analysis and examples from literature were provided. A representative sample ...article 2014
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Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...article 2014
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Blom, W.M. (author), Knulst, A. (author), Houben, G.F. (author)Food allergic patients average one unexpected allergic reaction per yeer. A major cause of reactions is the unintentional presence ofallergens in packaged foods as a result of cross contamination during production. Consumers encounter voluntary labeling alerts like "may contain traces of ..." which show a poor correlation with the actual...article 2014
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Höfer, T. (author), James, D. (author), Syversen, T. (author), Bowmer, T. (author)Data on acute lethal inhalation toxicity from animal studies are commonly required for assessing the hazards to human health of volatile, gaseous and dusty chemicals or their mixtures. The International Maritime Organisation (IMO) made the provision of acute inhalation toxicity data a mandatory requirement for the carriage of bulk liquid...article 2011
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Vink, S.R. (author), Mikkers, J. (author), Bouwman, T. (author), Marquart, H. (author), Kroese, E.D. (author), TNO Kwaliteit van Leven (author)REACH requests the exploration of alternative strategies for hazard identification before resorting to (in vivo) testing. Here, we combined read-across as non-testing strategy with a tiered exposure assessment for the risk characterisation of 1-methoxypropan-2-ol (PGME) as a representative for phase-in substances to be registered under REACH....article 2010
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Buist, H.E. (author), Schaafsma, G. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)Quantification of skin absorption is an essential step in reducing the uncertainty of dermal risk assessment. Data from literature indicate that the relative dermal absorption of substances is dependent on dermal loading. Therefore, an internal exposure calculated with absorption data determined at a dermal loading not comparable to the actual...article 2009
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Arts, J.H.E. (author), Muijser, H. (author), Jonker, D. (author), van de Sandt, J.J.M. (author), Bos, P.M.J. (author), Feron, V.J. (author), TNO Kwaliteit van Leven (author)The OECD Health Effects Test Guidelines (TGs) provide guidance concerning the use of methods for the identification and characterization of hazards from chemical substances. These TGs are largely based on tests in routine use for many years and are known to yield information relevant to various types of toxicity. They have proven their value in...article 2008
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- Dousma, M. (author), Wierdsma, N. (author), van Ede, J. (author), van Buuren, S. (author), Heijmans, H.S.A. (author), de Vries, T.W. (author), TNO Kwaliteit van Leven (author) article 2007
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Spanjersberg, M.Q.I. (author), Kruizinga, A.G. (author), Rennen, M.A.J. (author), Houben, G.F. (author), TNO Kwaliteit van Leven (author)In order to assess the risk of unintended exposure to food allergens, traditional deterministic risk assessment is usually applied, leading to inconsequential conclusions as 'an allergic reaction cannot be excluded'. TNO therefore developed a quantitative risk assessment model for allergens based on probabilistic techniques resulting in a more...article 2007
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Vink, P. (author), van Eijk, D.J. (author), TNO Kwaliteit van Leven (author)The use of hand tools can lead to accidents, overexertion injuries and discomfort. So, there is certainly room for better-designed hand tools, especially hand tools that contribute to better performance. In the literature, the benefits of a participative product design approach are clearly shown. However, the effect of this approach is hardly...article 2007
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Delleman, N.J. (author), Dul, J. (author), TNO Defensie en Veiligheid (author)Standards organizations have given considerable attention to the problem of work-related musculoskeletal disorders. The publication of international standards for evaluating working postures and movements, ISO 11226 in 2000 and EN 1005-4 in 2005, may be considered as a support for those involved in preventing and controlling these disorders. The...article 2007