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Genetic marker polymorphisms on chromosome 8q24 and prostate cancer in the Dutch population: DG8S737 may not be the causative variant

Zeegers, M.P. (author), Khan, H.S. (author), Schouten, L.J. (author), van Dijk, B.A.C. (author), Goldbohm, R.A. (author), Schalken, J. (author), Shajahan, S. (author), Pearlman, A. (author), Oddoux, C. (author), van den Brandt, P.A. (author), Ostrer, H. (author), TNO Kwaliteit van Leven (author)

Prostate cancer is the most commonly diagnosed cancer in men in Europe and Northern America. Genome-wide association studies (GWAS) have detected an association with markers on chromosome 8q24. Allele-8 of microsatellite DG8S737 with 22 repeats and allele A of the single-nucleotide polymorphism (SNP) rs1447295 have been found to be significantly...

article 2011

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A comparison of molecular technologies and genomotyping for tracing and strain characterization of Campylobacter isolates

van der Vossen, J. (author), Keijser, B. (author), Schuren, F. (author), Nocker, A. (author), Montijn, R. (author)

Thermophilic Campylobacter species are the most common cause of gastroenteritis in developed countries. Campylobacter spp. are ubiquitous in nature and widespread in livestock. Infections occur sporadically, and are believed to occur through consumption of contaminated meat products and from environmental sources. DNA-based techniques are...

conference paper 2011

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Metabolomics data exploration guided by prior knowledge

van den Berg, R.A. (author), Rubingh, C.M. (author), Westerhuis, J.A. (author), van der Werf, M.J. (author), Smilde, A.K. (author), TNO Kwaliteit van Leven (author)

In metabolomics research, it is often important to focus the data analysis to specific areas of interest within the metabolome. In this paper, we describe the application of consensus principal component analysis (CPCA) and canonical correlation analysis (CCA) as a means to explore the relation between metabolome data and (i) biochemically...

article 2009

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Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice

Duivenvoorden, I. (author), Voshol, P.J. (author), Rensen, P.C.N. (author), van Duyvenvoorde, W. (author), Romijn, J.A. (author), Emeis, J.J. (author), Havekes, L.M. (author), Nieuwenhuizen, W.F. (author), TNO Kwaliteit van Leven (author)

Background: The prevalence of dyslipidemia and obesity resulting from excess energy intake and physical inactivity is increasing. The liver plays a pivotal role in systemic lipid homeostasis. Effective, natural dietary interventions that lower plasma lipids and promote liver health are needed. Objective: Our goal was to determine the effect of...

article 2006

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Behavioural effects and kinetics in brain in response to inhalation of constant or fluctuating toluene concentrations in the rat

Lammers, J.H.C.M. (author), van Asperen, J. (author), de Groot, D. (author), Rijcken, W.R.P. (author), TNO Kwaliteit van Leven (author)

The toxicity of exposure by inhalation to organic solvents may not only be related to the total external dose, but also to the pattern of exposure. In this study the impact of the exposure scenario on the behavioural effects of the model solvent toluene in rats was investigated. Rats were exposed for 7.5 h to either a constant concentration or...

article 2005

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Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro

van Erk, M.J. (author), Roepman, P. (author), van der Lende, T.R. (author), Stierum, R.H. (author), Aarts, J.M.M.J.G. (author), van Bladeren, P.J. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)

Background: Many different mechanisms are involved in nutrient-related prevention of colon cancer. In this study, a comprehensive assessment of the spectrum of possible biological actions of the bioactive compound quercetin is made using multiple gene expression analysis. Quercetin is a flavonoid that can inhibit proliferation of tumor cells and...

article 2005

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Evaluation of the in vivo genetic toxicity of concentrated barley β-glucan

Delaney, B. (author), de Vogel, N. (author), Krul, C.A.M. (author), TNO Voeding (author)

Chemicals / CAS: corn oil, 8001-30-7; mitomycin C, 50-07-7, 74349-48-7; Glucans; Mutagens

article 2004

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Advanced glycation end product ligands for the receptor for advanced glycation end products: Biochemical characterization and formation kinetics

Valencia, J.V. (author), Weldon, S.C. (author), Quinn, D. (author), Kiers, G.H. (author), de Groot, J. (author), TeKoppele, J.M. (author), Hughes, T.E. (author), Gaubius instituut TNO (author)

Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown. Using standardized procedures and a variety of...

article 2004

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The effect of lactulose on the activity of the microbiota and short chain fatty acid production in de large intetine: Comparision of in vivo and in vitro experiments

Venema, K. (author), van Nuenen, M. (author), van den Heuvel, E. (author), Pool, W. (author), van der Vossen, J.M.B.M. (author), TNO Voeding (author)

conference paper 2003

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Efficacy of a natural magnesium smectite against aflatoxin B1 and zearalenone tested in a dynamic in vitro model of the gastric and small intestine simulating the pig

Zeijdner, E.E. (author), Sidler, S. (author), Gómez, G. (author), Havenaar, R. (author), Escribano, F. (author), TNO Voeding (author)

conference paper 2003

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Biomarkers for intestinal health: Effect of inulin and its microbial fermentation products on the metabolic profile of cultured enterocytes

Venema, K. (author), van Nesselrooij, J. (author), Lamers, R.J. (author), Havenaar, R. (author), van de Sandt, J. (author), TNO Voeding (author)

conference paper 2003

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K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study

Brink, M. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), Pachen, M.M.M. (author), Smits, K.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)

Activation of K-ras oncogene has been implicated in colorectal carcinogenesis, being mutated in 30-60% of the adenocarcinomas. In this study, 737 incident colorectal cancer (CRC) patients, originating from 120 852 men and women (55-69 years at baseline) participating in the Netherlands Cohort Study (NLCS), were studied in order to evaluate...

article 2003

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Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats

van Bladeren, P.J. (author), van Ommen, B. (author), TNO Voeding (author)

article 2003

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Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women

Olthof, M.R. (author), van Vliet, T. (author), Boelsma, E. (author), Verhoef, P. (author)

High plasma homocysteine is a risk for cardiovascular disease and can be lowered through supplementation with 6 g/d of betaine. However, dietary intake of betaine is ∼0.5-2 g/d. Therefore, we investigated whether betaine supplementation in the range of dietary intake lowers plasma homocysteine concentrations in healthy adults. Four groups of 19...

article 2003

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Putative role of lysyl hydroxylation and pyridinoline cross-linking during adolescence in the occurrence of osteoarthritis at old age

Bank, R.A. (author), Verzijl, N. (author), Lafeber, F.P.J.G. (author), Tekoppele, J.M. (author), Gaubius instituut TNO TNO Preventie en Gezondheid (author)

Objective: The collagen network in human articular cartilage experiences a large number of stress cycles during life as it shows hardly any turnover after adolescence. We hypothesized that, to withstand fatigue failure, the physical condition of the collagen network laid down at adolescence is of crucial importance for the age of onset of...

article 2002

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Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis

Verzijl, N. (author), de Groot, J. (author), Zaken, C.B. (author), Braun-Benjamin, O. (author), Maroudas, A. (author), Bank, R.A. (author), Mizrahi, J. (author), Schalkwijk, C.G. (author), Thorpe, S.R. (author), Baynes, J.W. (author), Bijlsma, J.W.J. (author), Lafeber, F.P.J.G. (author), TeKoppele, J.M. (author), Gaubius Instituut TNO (author)

Objective. Age is an important risk factor for osteoarthritis (OA). During aging, nonenzymatic glycation results in the accumulation of advanced glycation end products (AGEs) in cartilage collagen. We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage. Methods. To increase AGE levels,...

article 2002

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A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis

Huebner, J.L. (author), Hanes, M.A. (author), Beekman, B. (author), TeKoppele, J.M. (author), Kraus, V.B. (author), Gaubius Instituut (author)

Objective: To evaluate the interaction of bone and cartilage in knee osteoarthritis (OA) pathogenesis in two guinea-pig strains with appreciable differences in bone metabolism. Design: Two guinea-pig strains were evaluated for their susceptibilities to OA using semi-quantitative histological grading of knee joints and quantification of...

article 2002

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Biochemical development of subchondral bone from birth until age eleven months and the influence of physical activity

Brama, P.A.J. (author), TeKoppele, J.M. (author), Bank, R.A. (author), Barneveld, A. (author), van Weeren, P.R. (author), Gaubius instituut TNO (author)

Subchondral bone provides structural support to the overlying articular cartilage, and plays an important role in osteochondral diseases. There is growing insight that the mechanical features of bone are related to the biochemistry of the collagen network and the mineral content. In the present study, part of the normal developmental process and...

article 2002

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Development of biochemical heterogeneity of articular cartilage: Influences of age and exercise

Brama, P.A.J. (author), Tekoppele, J.M. (author), Bank, R.A. (author), Barneveld, A. (author), van Weeren, P.R. (author), Gaubius Instituut TNO (author)

The objective of this study was to document the development of biochemical heterogeneity from birth to maturity in equine articular cartilage, and to test the hypothesis that the amount of exercise during early life may influence this process. Neonatal foals showed no biochemical heterogeneity whatsoever, in contrast to a clear biochemical...

article 2002

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Bone turnover, joint damage and bone mineral density in early rheumatoid arthritis treated with combination therapy including high-dose prednisolone

Verhoeven, A.C. (author), Boers, M. (author), te Koppele, J.M. (author), van der Laan, W.H. (author), Markusse, H.M. (author), Geusens, P. (author), van der Linden, S. (author), Gaubius Instituut (author)

Objectives. Exploration of bone metabolism changes at different levels of disease activity, both with and without oral corticosteroid therapy, and prediction of changes in joint damage and bone density from the observed changes in markers of bone turnover. Methods. Data analysis from a randomized clinical trial with 155 rheumatoid arthritis (RA)...

article 2001