Searched for: subject%3A%22Hazard%255C%2Bassessment%22
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Bajard, L. (author), Adamovsky, O. (author), Audouze, K. (author), Baken, K. (author), Barouki, R. (author), Beltman, J. (author), Beronius, A. (author), Bonefeld-Jørgensen, E.C. (author), Cano-Sancho, G. (author), de Baat, M.L. (author), Di Tillio, F. (author), Fernández, M.F. (author), FitzGerald, R.E. (author), Gundacker, C. (author), Hernández, A.F. (author), Hilscherova, K. (author), Karakitsios, S. (author), Kuchovska, E. (author), Long, M. (author), Luijten, M. (author), Majid, S. (author), Marx-Stoelting, P. (author), Mustieles, V. (author), Negi, C.K. (author), Sarigiannis, D. (author), Scholz, S. (author), Sovadinova, I. (author), Stierum, R. (author), Tanabe, S. (author), Tollefsen, K.E. (author), van den Brand, A.D. (author), Vogs, C. (author), Wielsøe, M. (author), Wittwehr, C. (author), Blaha, L. (author)
While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreover, human epidemiological studies with biomarkers of effect (BoE) also play an invaluable role in...
article 2023
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van Ginkel, J. (author), Ruigrok, E. (author), Stafleu, J. (author), Herber, R. (author)
Earthquake site response is an essential part of seismic hazard assessment, especially in densely populated areas. The shallow geology of the Netherlands consists of a very heterogeneous soft sediment cover, which has a strong effect on the amplitude of ground shaking. Even though the Netherlands is a low- to moderate-seismicity area, the seis...
article 2022
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Sewell, F. (author), Strupp, C. (author), van der Laan, J.W. (author), Wolf, D.C. (author), Wolterink, G. (author), Woutersen, R. (author), Zvonar, Z. (author), Heusinkveld, H. (author), Braakhuis, H. (author)
Currently the only methods for non-genotoxic carcinogenic hazard assessment accepted by most regulatory authorities are lifetime carcinogenicity studies. However, these involve the use of large numbers of animals and the relevance of their predictive power and results has been scientifically challenged. With increased availability of innovative...
article 2020
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Heusinkveld, H. (author), Braakhuis, H. (author), Gommans, R. (author), Botham, P. (author), Corvaro, M. (author), van der Laan, J.W. (author), Lewis, D. (author), Madia, F. (author), Manou, I. (author), Schorsch, F. (author), Wolterink, G. (author), Woutersen, R. (author), Corvi, R. (author), Mehta, J. (author), Luijten, M. (author)
Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For agrochemicals, the long-term rodent carcinogenicity study is currently required from a regulatory perspective. Although it is the current mainstay for the detection of nongenotoxic...
article 2020
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Graepel, R. (author), ter Braak, B. (author), Escher, S.E. (author), Fisher, C. (author), Gardner, I. (author), Kamp, H. (author), Kroese, D. (author), Leist, M. (author), Moné, M.J. (author), Pastor, M. (author), van de Water, B. (author)
The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM)–based approaches for risk assessment. In this European research project, experts in the fields of in vitro and in silico techniques and risk assessment from academia, industry and...
article 2019
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Luijten, M. (author), Olthof, E.D. (author), Hakkert, B.C. (author), Rorije, E. (author), van der Laan, J.-W. (author), Woutersen, R.A. (author), van Benthem, J. (author)
Assessment of genotoxic and carcinogenic potential is considered one of the basic requirements when evaluating possible human health risks associated with exposure to chemicals. Test strategies currently in place focus primarily on identifying genotoxic potential due to the strong association between the accumulation of genetic damage and cancer...
article 2016
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Ball, N. (author), Cronin, M.T.D. (author), Shen, J. (author), Blackburn, K. (author), Booth, E.D. (author), Bouhifd, M. (author), Donley, E. (author), Egnash, L. (author), Hastings, C. (author), Juberg, D.R. (author), Kleensang, A. (author), Kleinstreuer, N. (author), Kroese, E.D. (author), Lee, A.C. (author), Luechtefeld, T. (author), Maertens, A. (author), Marty, S. (author), Naciff, J.M. (author), Palmer, J. (author), Pamies, D. (author), Penman, M. (author), Richarz, A.N. (author), Russo, D.P. (author), Stuard, S.B. (author), Patlewicz, G. (author), van Ravenzwaay, B. (author), Wu, S. (author), Zhu, H. (author), Hartung, T. (author)
Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key...
article 2016
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Burello, E. (author), Worth, A.P. (author)
article 2015
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...
article 2015
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Dusinska, M. (author), Boland, S. (author), Saunders, M. (author), Juillerat-Jeanneret, L. (author), Tran, L. (author), Pojana, G. (author), Marcomini, A. (author), Volkovova, K. (author), Tulinska, J. (author), Knudsen, L.E. (author), Gombau, L. (author), Whelan, M. (author), Collins, A.R. (author), Marano, F. (author), Housiadas, C. (author), Bilanicova, D. (author), Halamoda Kenzaoui, B. (author), Correia Carreira, S. (author), Magdolenova, Z. (author), Fjellsbo, L.M. (author), Huk, A. (author), Handy, R. (author), Walker, L. (author), Barancokova, M. (author), Bartonova, A. (author), Burello, E. (author), Castell, J. (author), Cowie, H. (author), Drlickova, M. (author), Guadagnini, R. (author), Harris, G. (author), Harju, M. (author), Heimstad, E.S. (author), Hurbankova, M. (author), Kazimirova, A. (author), Kovacikova, Z. (author), Kuricova, M. (author), Liskova, A. (author), Milcamps, A. (author), Neubauerova, E. (author), Palosaari, T. (author), Papazafiri, P. (author), Pilou, M. (author), Poulsen, M.S. (author), Ross, B. (author), Runden-Pran, E. (author), Sebekova, K. (author), Staruchova, M. (author), Vallotto, D. (author), Worth, A. (author)
In spite of recent advances in describing the health outcomes of exposure to nanoparticles (NPs), it still remains unclear how exactly NPs interact with their cellular targets. Size, surface, mass, geometry, and composition may all play a beneficial role as well as causing toxicity. Concerns of scientists, politicians and the public about...
article 2015
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Bruhn, D.F. (author), Águstsson, K. (author), Zang, A. (author), Rachez, X. (author), Wiemer, S. (author), Van Wees, J.D. (author), Calcagno, P. (author), Huenges, E. (author)
GEISER was a European project on understanding and mitigation of induced seismicty in geothermal operations. The project involved several European research institutions as well as industry and was funded by the European Commission within FP7. GEISER addressed a better understanding of the key parameters that control induced seismicity in...
conference paper 2014
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Steeghs, P. (author), Vandeweijer, V.P. (author), Meekes, J.A.C. (author), Paap, B.F. (author), de Kleine, M.P.E. (author)
TNO has carried out a high resolution 3D seismic survey off-shore Rotterdam. The new deployment concept that was tested with this survey results in high-quality 3D images of the shallow subsurface at relatively low cost, particularly in comparison with conventional 3D seismic data acquisition. Initially, the pilot survey aims to demonstrate the...
conference paper 2014
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van Duuren-Stuurman, B. (author), Vink, S. (author), Brouwer, D. (author), Kroese, E.D. (author), Heussen, H. (author), Verbist, K. (author), Tielemans, E. (author), van Niftrik, M. (author), Fransman, W. (author)
Stoffenmanager Nano (version 1.0) is a risk-banding tool developed for employers and employees to prioritize health risks occurring as a result of exposure to manufactured nano objects (MNOs) for a broad range of worker scenarios and to assist implementation of control measures to reduce exposure levels. In order to prioritize the health risks,...
article 2012
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Höfer, T. (author), James, D. (author), Syversen, T. (author), Bowmer, T. (author)
Data on acute lethal inhalation toxicity from animal studies are commonly required for assessing the hazards to human health of volatile, gaseous and dusty chemicals or their mixtures. The International Maritime Organisation (IMO) made the provision of acute inhalation toxicity data a mandatory requirement for the carriage of bulk liquid...
article 2011
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Yerli, B. (author), ten Veen, J. (author), Sintubin, M. (author)
Geologists, seismologists, as well as archaeologists increasingly apply archaeoseismological investigations to study possible natural causes of damage of a site and to assess the regional seismic hazard risks. Archaeoseismological investigations enable the obtaining of diverse data on past earthquakes and allow for an application of different...
article 2011
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Schaafsma, G. (author), Kroese, E.D. (author), Tielemans, E.L.J.P. (author), van de Sandt, J.J.M. (author), van Leeuwen, C.J. (author), TNO Kwaliteit van Leven (author)
The objectives of REACH cannot be achieved under the current risk assessment approach. A change in mind set among all the relevant stakeholders is needed: risk assessment should move away from a labor-intensive and animal-consuming approach to intelligent and pragmatic testing, by combining exposure and hazard data effectively and trying to...
article 2009
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Hofstee, C. (author), Seeberger, F. (author), Orlic, B. (author), Mulders, F. (author), van Bergen, F. (author), Bisschop, R. (author), TNO Bouw en Ondergrond (author)
article 2008
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Jonkman, S.N. (author), Vrijling, J.K. (author), Vrouwenvelder, A.C.W.M. (author), TNO Bouw en Ondergrond (author)
This article deals with methods for the estimation of loss of life due to flooding. These methods can be used to assess the flood risks and to identify mitigation strategies. The first part of this article contains a comprehensive review of existing literature. Methods have been developed for different types of floods in different regions. In...
article 2008
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Fransman, W. (author), Roeleveld, N. (author), Peelen, S. (author), de Kort, W. (author), Kromhout, H. (author), Heederik, D. (author), TNO Kwaliteit van Leven (author)
BACKGROUND: Nurses and other hospital workers are exposed to antineoplastic drugs during daily activities. Previous studies suggest that antineoplastic drugs at occupational exposure levels may be toxic to reproduction, but these studies are not consistent or conclusive. METHODS: Self-administered questionnaires were completed by 4393 exposed...
article 2007
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Freidig, A.P. (author), Dekkers, S. (author), Verwei, M. (author), Zvinavashe, E. (author), Bessems, J.G.M. (author), van de Sandt, J.J.M. (author), TNO Kwaliteit van Leven (author)
Future EU legislations enforce a fast hazard and risk assessment of thousands of existing chemicals. If conducted by means of present data requirements, this assessment will use a huge number of test animals and will be neither cost nor time effective. The purpose of the current research was to develop methods to increase the acceptability of in...
article 2007
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