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Amirijoo, M. (author), Litjens, R. (author), Spaey, K. (author), Döttling, M. (author), Jansen, T. (author), Scully, N. (author), Türke, U. (author), TNO Informatie- en Communicatietechnologie (author)Self-organisation (self-optimisation, self-configuration, and self-healing) methods are a promising concept to automate wireless access network planning, deployment and optimisation. This paper contains a mind setting exercise. First the mechanisms for which self-organisation is anticipated to be effective and feasible are identified. Then...bookPart 2008
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Ainola, M. (author), Valleala, H. (author), Nykänen, P. (author), Risteli, J. (author), Hanemaaijer, R. (author), Konttinen, Y.T. (author), TNO Kwaliteit van Leven (author)Objective. The excellent poster painter Henri de Toulouse-Lautrec is the most famous patient with cathepsin K-deficient pycnodysostosis. Cathepsin K is believed to play a major role in osteoclast-driven bone resorption. In this study we explored the role of cathepsin K in bone resorption in a patient with a cathepsin K mutation causing...article 2008
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Huysmans, M.A. (author), Hoozemans, M.J.M. (author), van der Beek, A.J. (author), de Looze, M.P. (author), van Dieën, J.H. (author), TNO Kwaliteit van Leven (author)It has been suggested that fatigue affects proprioception and consequently movement accuracy, the effects of which may be counteracted by increased muscle activity. To determine the effects of fatigue on tracking performance and muscle activity in the M. extensor carpi radialis (ECR), 11 female participants performed a 2-min tracking task with a...article 2008
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TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Vanwersch, R.A.P. (author), Jongsma, M.J. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author)Current therapies for Parkinson's disease (PD) like l-dopa and dopamine (DA) agonists have declined efficacy after long term use. Therefore, research towards supplementary or alternative medication is needed. The implementation in PD can be expedited by application of compounds already used in the clinic. In this study the therapeutic effects of...article 2008
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- TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Jongsma, M.J. (author), Vanwersch, R.A.P. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author) article 2008
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van Wendel de Joode, B. (author), Vermeulen, R. (author), Heederik, D. (author), van Ginkel, K. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)We performed an exploratory study to evaluate 2 self-administered questionnaires assessing hand dermatitis and investigate a possible exposure-response relationship between dermal exposure to semi-synthetic metalworking fluids (SMWF) and dermatitis. In a cross-sectional survey on dermatitis, a symptom-based questionnaire and a picture-based skin...article 2007
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Tielemans, E. (author), Bretveld, R. (author), Schinkel, J. (author), de Wendel van - Joode, B. (author), Kromhout, H. (author), Gerritsen-Ebben, R. (author), Roeleveld, N. (author), Preller, L. (author), TNO Kwaliteit van Leven (author)The aim of this study was to assess exposure to pesticides for a longitudinal epidemiological study on adverse reproduction effects among greenhouse workers. Detailed information on pesticide use among greenhouse workers was obtained on a monthly basis through self-administered questionnaires and subsequent workplace surveys. Questionnaires were...article 2007
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Meulenbelt, I. (author), Kloppenburg, M. (author), Kroon, H.M. (author), Houwing-Duistermaat, J.J. (author), Garnero, P. (author), Hellio-Le Graverand, M.-P. (author), de Groot, J. (author), Slagboom, P.E. (author), TNO Kwaliteit van Leven (author)Objective: To assess the relationship of biochemical markers and radiographic signs of osteoarthritis (ROA) in the subjects with symptomatic osteoarthritis (OA) at multiple sites of the Genetics osteoARthritis and Progression (GARP) study. Methods: We have measured eight biochemical markers, representing tissue turnover of cartilage, bone,...article 2007
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IJmker, S. (author), Huysmans, M.A. (author), Blatter, B.M. (author), van der Beek, A.J. (author), van Mechelen, W. (author), Bongers, P.M. (author), TNO Kwaliteit van Leven (author)Worldwide, millions of office workers use a computer. Reports of adverse health effects due to computer use have received considerable media attention. This systematic review summarises the evidence for a relationship between the duration of work time spent using the computer and the incidence of hand-arm and neck-shoulder symptoms and disorders...article 2007
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Links, I. (author), Jagt, K.E.V.D. (author), Christopher, Y. (author), Lurvink, M. (author), Schinkel, J. (author), Tielemans, E. (author), Hemmen, J.J.V. (author), TNO Kwaliteit van Leven (author)Exposure data on biocides are relatively rare in published literature, especially for secondary exposure. This is also the case for antifouling exposure. Therefore, a field study was carried out measuring exposure to antifouling paints. Both primary exposure (rolling and spraying) and secondary exposure (during sand blasting) were studied....article 2007
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Kuijt-Evers, L.F.M. (author), Vink, P. (author), de Looze, M.P. (author), TNO Kwaliteit van Leven (author)This study investigates whether the same factors underlie comfort in using different kinds of hand tools (screwdrivers, paintbrushes and handsaws). The underlying factors of the hand tools are identified using principal components analysis. The relationships between comfort descriptors (i.e. statements in end-users' own words that are related to...article 2007
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van den Heuvel, S.G. (author), IJmker, S. (author), Blatter, B.M. (author), de Korte, E.M. (author), TNO Kwaliteit van Leven (author)Introduction: The objective of the present study is to describe the extent of productivity loss among computer workers with neck/shoulder symptoms and hand/arm symptoms, and to examine associations between pain intensity, various physical and psychosocial factors and productivity loss in computer workers with neck/shoulder and hand/arm symptoms....article 2007
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Kuijt-Evers, L.F.M. (author), Bosch, T. (author), Huysmans, M.A. (author), de Looze, M.P. (author), Vink, P. (author), TNO Kwaliteit van Leven (author)In the current study, the relationship between objective measurements and subjective experienced comfort and discomfort in using handsaws was examined. Twelve carpenters evaluated five different handsaws. Objective measures of contact pressure (average pressure, pressure area and pressure-time (P-t) integral) in static and dynamic conditions,...article 2007
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Vink, P. (author), van Eijk, D.J. (author), TNO Kwaliteit van Leven (author)The use of hand tools can lead to accidents, overexertion injuries and discomfort. So, there is certainly room for better-designed hand tools, especially hand tools that contribute to better performance. In the literature, the benefits of a participative product design approach are clearly shown. However, the effect of this approach is hardly...article 2007
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Hueber-Becker, F. (author), Nohynek, G.J. (author), Dufour, E.K. (author), Meuling, W.J.A. (author), de Bie, A.T.H.J. (author), Toutain, H. (author), Bolt, H.M. (author), TNO Kwaliteit van Leven (author)We monitored the exposure of hairdressers to oxidative hair dyes for 6 working days under controlled conditions. Eighteen professional hairdressers (3/day) coloured hairdresser's training heads bearing natural human hair (hair length: approximately 30 cm) for 6 h/working day with a dark-shade oxidative hair dye containing 2% [14C]-para...article 2007
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Huysmans, M.A. (author), de Looze, M.P. (author), Hoozemans, M.J.M. (author), van der Beek, A.J. (author), van Dieën, J.H. (author), TNO Kwaliteit van Leven (author)The study was designed to determine the effect of joystick handle size and (display-control) gain at two levels of required task precision on performance and physical load on crane operators. Eight experienced crane operators performed a simulated crane operation task on a computer by use of a joystick with either a short or a large handle. The...article 2006
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Geng, Q. (author), Holme, I. (author), den Hartog, E.A. (author), Havenith, G. (author), Jay, O. (author), Malchaires, J. (author), Piette, A. (author), Rintama, H. (author), Rissanen, S. (author), TNO Defensie en Veiligheid (author)Objectives: At the request of the European Commission and in the framework of the European Machinery Directive, research was performed in five different laboratories to develop specifications for surface temperature limit values for the short-term accidental touching of the fingertip with cold surfaces. Methods: Data were collected in four...article 2006
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Marquart, H. (author), Warren, N.D. (author), Laitinen, J. (author), van Hemmen, J.J. (author), TNO Kwaliteit van Leven (author)Dermal exposure needs to be addressed in regulatory risk assessment of chemicals. The models used so far are based on very limited data. The EU project RISKOFDERM has gathered a large number of new measurements on dermal exposure to industrial chemicals in various work situations, together with information on possible determinants of exposure....article 2006
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TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Vanwersch, R.A.P. (author), Jongsma, M.J. (author), van der Gugten, J. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author)The vigilance-enhancing agent modafinil has neuroprotective properties: it prevents striatal ischemic injury, nigrostriatal pathway deterioration after partial transsection and intoxication with 1-methyl-1,2,3,6-tetrahydropyridine. The present study determines the protective effects of modafinil in the marmoset 1-methyl-1,2,3,6...article 2006
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TNO Defensie en Veiligheid (author), van Vliet, S.A.M. (author), Jongsma, M.J. (author), Vanwersch, R.A.P. (author), Olivier, B. (author), Philippens, I.H.C.H.M. (author)Rationale: Modafinil is increasingly used in sleep disturbances in general and in neurodegenerative diseases and is recently being used in healthy people for attention control. However, the application of modafinil is possibly not only restricted to alertness enhancing effects. More insight in this compound may lead to new applications. Not all...article 2006