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Spini, G. (author), Mancini, E. (author), Attema, T. (author), Abspoel, M. (author), de Gier, J. (author), Fehr, S. (author), Veugen, T. (author), van Heesch, M. (author), Worm, D. (author), de Luca, A. (author), Cramer, R. (author), Sloot, P.M.A. (author)BackgroundHIV treatment prescription is a complex process. Clinical decision support systems (CDSS) are a category of health information technologies that can assist clinicians to choose optimal treatments based on clinical trials and expert knowledge. The usability of some CDSSs for HIV treatment would be significantly improved by using the...article 2022
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Liu, J. (author), O'Brien, K.L. (author), Lynch, D.M. (author), Simmons, N.L. (author), La Porte, A. (author), Riggs, A.M. (author), Abbink, P. (author), Coffey, R.T. (author), Grandpre, L.E. (author), Seaman, M.S. (author), Landucci, G. (author), Forthal, D.N. (author), Montefiori, D.C. (author), Carville, A. (author), Mansfield, K.G. (author), Havenga, M.J. (author), Pau, M.G. (author), Goudsmit, J. (author), Barouch, D.H. (author), TNO Kwaliteit van Leven (author)A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads after SIV challenge of rhesus...article 2009
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den Boer, M.A.M. (author), Berbée, J.F.P. (author), Reiss, P. (author), van der Valk, M. (author), Voshol, P.J. (author), Kuipers, F. (author), Havekes, L.M. (author), Rensen, P.C.N. (author), Romijn, J.A. (author), Gaubius Instituut TNO (author)Objective - The use of the HIV protease inhibitor ritonavir (RTV) is frequently associated with hypertriglyceridemia and lipodystrophy. The aim of our study was to determine the mechanism underlying the observed hypertriglyceridemia. Methods and Results - Feeding female APOE*3-Leiden transgenic mice a Western-type diet supplemented with RTV (35...article 2006
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Martin, A.M. (author), Hammond, E. (author), Nolan, D. (author), Pace, C. (author), Den Boer, M. (author), Taylor, L. (author), Moore, H. (author), Martinez, O.P. (author), Christiansen, F.T. (author), Mallal, S. (author), TNO Preventie en Gezondheid (author)Nucleoside reverse-transcriptase inhibitor (NRTI) therapy for human immunodeficiency virus (HIV) infection has been associated with mitochondrial DNA (mtDNA) polymerase-γ inhibition and subsequent mtDNA depletion. Effects on mtDNA mutation, although suggested by critical involvement of polymerase-γ in DNA-repair reactions, are unknown. In the...article 2003
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TNO Arbeid (author), Weiss, J.J. (author), Mulder, C.L. (author), Antoni, M.H. (author), Vroome, E.M.M.de (author), Garssen, B. (author), Goodkin, K. (author)Background: This study compared the effects of a supportive-expressive group intervention (GI) with an educational control condition (EC) on long-term psychosocial adjustment in gay men with HIV infection. Method: Subjects (n = 85) were randomized after stratification for disease stage and use of antiretroviral medication. GI consisted of 4...article 2003
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Verhoeff, F.H. (author), Brabin, B.J. (author), van Buuren, S. (author), Chimsuku, L. (author), Kazembe, P. (author), Wit, J.M. (author), Broadhead, R.L. (author)Objective: (1) To describe the sex-specific, birth weight distribution by gestational age of babies born in a malaria endemic, rural area with high maternal HIV prevalence; (2) to assess the contribution of maternal health, nutritional status and obstetric history on intra-uterine growth retardation (IUGR) and prematurity. Methods: Information...article 2001
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- Beltman, J.J. (author), Segaar, M. (author), Ory, F.G. (author), TNO Preventie en Gezondheid (author) article 2000
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- Laman, J.D. (author), van den Eertwegh, A.J.M. (author), Parmentier, H.K. (author), Schuurman, H.J. (author), Medisch Biologisch Laboratorium TNO (author) article 1992