Does the risk of childhood diabetes mellitus require revision of the guideline values for nitrate in drinking water?

In recent years, several studies have addressed a possible relationship between nitrate exposure and childhood type 1 insulin-dependent diabetes mellitus. The present ecologic study describes a possible relation between the incidence of type 1 diabetes and nitrate levels in drinking water in The Netherlands, and evaluates whether the World...

Emperical validation of team training ID-Guidelines

With respect to team training, traditional instructional design (ID) guidelines, mainly aimed at training at the individual level, seem to be insufficient given the different nature and characteristics of teams and team performance. In order to provide adequate support, guidelines have been developed supporting the analysis of team tasks, and...

An international development of a driver-centered guideline for road design

Voorgesteld wordt om op basis van internationale samenwerking veiligheidsrichtlijnen te ontwikkelen waarbij de bestuurder centraal staat. Dit als aanvulling op bestaande wegontwerp- en verkeerskunde handboeken,

Eye irritation testing: The way forward : the report and recommendations of ECVAM workshop 34

Food-based dietary guidelines: some assumptions tested for the Netherlands

Recently, the concept of food-based dietary guidelines has been introduced by WHO and FAO. For this concept, several assumptions were necessary. The validity and potential consequences of some of these assumptions are discussed in this paper on the basis of the Dutch National Food Consumption Surveys. The topics were interrelationships among...

Reactie: Economische evaluatie binnen de cardiologie : Achtergrond en toepassing [Economic evaluation within cardiology : Background and application]

Toxicological evaluation and risk assessment of chemical mixtures

A major objective of combination toxicology is to establish whether a mixture of chemicals will result in an effect similar to that expected on the basis of additivity. This requires understanding of the basic concepts of the combined toxicological action of the compounds of the mixture: simple similar action (dose addition), simple dissimilar...

Fifteen years experience with finger arterial pressure monitoring: Assessment of the technology

We review the Finapres technology, embodied in several TNO-prototypes and in the Ohmeda 2300 and 2300e Finapres NIBP. Finapres is an acronym for FINger Arterial PRESsure, the device delivers a continuous finger arterial pressure waveform. Many papers report on the accuracy of the device in comparison with intra-arterial or with noninvasive but...

Intrinsic and enhanced bioremediation in aquifers contaminated with chlorinated and aromatic hydrocarbons in The Netherlands

The feasibility of intrinsic and enhanced bioremediation approaches for 16 contaminated sites in the Netherlands are discussed. At at least five out of 10 chlorinated solvent sites, natural attenuation can be used as one of the tools to prevent further dispersion of the plume. At two sites stimulation of the intrinsic dechlorination processes in...

Summary of the report 'Toxicology-Based Recommended Exposure Limits'

Complex mixtures: Hazard identification and risk assessment

Regarding risk evaluation of complex mixtures, the Working Group discussed the following topics: evaluation of the mixture as a whole, fractionation of the mixture, identification of the 'top ten' chemicals, and composite standards. It was concluded that no standard methodology for hazard identification and risk assessment of complex mixtures...

Regulations, policies and practices concerning work stress in five European countries

A comparative inventory of regulations, policies and practices in The Netherlands, Sweden, UK, Germany and France with regard to the prevention of work stress was carried out. In each country data were collected by means of interviews with key informants and through exploring relevant documents and literature. It was found that Sweden. The...

Ergonomic guidelines for the prevention of discomfort of static postures based on endurance data

This communication aims to show why guidelines to prevent discomfort of static postures can be based on endurance data, and to give insight in the aim and scope of a recent 'work-rest model for static postures' (WR model). The paper is a response to a recent paper of Mathiassen and Winkel (1992) who questioned the usefulness of discomfort and...