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van Dommelen, P. (author), Barios, R.M. (author), Arnaud, L. (author), le Masne, Q. (author), Koledova, E. (author)Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March...article 2023
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van Dommelen, P. (author), Arnaud, L. (author), Koledova, E.B. (author)Curve matching may be used to predict growth outcomes using data of patients whose growth curves resemble those of a new patient with growth hormone deficiency (GHD) and those born small for gestational age (SGA). We aimed to investigate the validity of curve matching to predict growth in patients with GHD and those born SGA receiving...article 2022
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background. Our aim was to develop a machine learning model, using real-world data captured from a connected auto-injector device and from early indicators from the first 3 months of treatment, to predict sub-optimal adherence to recombinant human growth hormone (r-hGH) in patients with growth disorders. Methods. Adherence to r-hGH treatment was...article 2022
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Morgan, K. (author), van Dommelen, P. (author), Batista, A.R. (author), Koledova, E. (author)We explored whether a multi-component approach - using a digital health device, the easypod™ auto-injector, the 'MySupport' patient support programme (PSP) and a Patient Activation Measure® (PAM®) - could improve adherence in patients receiving recombinant human growth hormone (r-hGH). A 13-item PAM was used to assess caregiver self-reported...bookPart 2022
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Assefi, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Otero, C. (author), Fernandez-Luque, L. (author), Koledova, E. (author), Calliari, L.E. (author)Background: Recombinant human growth hormone (rhGH) therapy is an effective treatment for children with growth disorders. However, poor outcomes are often associated with suboptimal adherence to treatment. Objective: The easypod connected injection device records and transmits injection settings and dose data from patients receiving rhGH. In...article 2022
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- van Dommelen, P. (author) public lecture 2021
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Wit, J.M. (author), Sas, T.C.J. (author), Ranke, M.B. (author), van Dommelen, P. (author)Background/aims: We hypothesized that modelling catch-up growth (CUG) as developed for coeliac disease (CD), might also fit CUG in adequately treated children with juvenile hypothyroidism (JHT) or growth hormone deficiency (GHD). Methods: We used a monomolecular function for all available prepubertal data on height SDS minus target height SDS ...article 2021
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Spataru, A. (author), van Dommelen, P. (author), Arnaud, L. (author), Le Masne, Q. (author), Quarteroni, S. (author), Koledova, E.B. (author)Background: Suboptimal adherence to recombinant human growth hormone (r-hGH) treatment can lead to suboptimal clinical outcomes. Being able to identify children who are at risk of suboptimal adherence in the near future, and take adequate measures to support adherence, may maximize clinical outcomes. Our aim was to develop a model based on data...article 2021
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Araujo, M. (author), van Dommelen, P. (author), Srivastava, J. (author), Koledova, E. (author)Recombinant human growth hormone (r-hGH) is an established therapy for growth hormone deficiency (GHD); yet, some patients fail to achieve their full height potential, with poor adherence and persistence with the prescribed regimen often a contributing factor. A data-driven clinical decision support system based on “traffic light” visualizations...article 2021
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Araujo, M. (author), van Dommelen, P. (author), Koledova, E.B. (author), Srivastava, J. (author)The problem of consistent therapy adherence is a current challenge for health informatics, and its solution can increase the success rate of treatments. Here we show a methodology to predict, at individual-level, future therapy adherence for patients receiving daily injections of growth hormone (GH) therapy for GH deficiency. Our proposed model...article 2021
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Koledova, E. (author), Tornincasa, V. (author), van Dommelen, P. (author)Background. Poor adherence to long-term recombinant human growth hormone (r-hGH) treatment can lead to suboptimal clinical outcomes; consequently, supporting and monitoring adherence is a crucial part of patient management. We assessed adherence to r-hGH treatment in children with growth disorders over 48 months using a connected monitoring...article 2020
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van Dommelen, P. (author), Koledova, E. (author), Wit, J.M. (author)Background. Quantifying the association between adherence and the growth response to growth hormone (GH) treatment is hampered by suboptimal methods of measuring adherence, confounders associated with the growth response, and restriction of the outcome parameters to yearly growth velocities. Aim. To investigate the effect of adherence on the two...article 2018
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Vis, D.J. (author), Westerhuis, J.A. (author), Hoefsloot, H.C.J. (author), Roelfsema, F. (author), van der Greef, J. (author), Hendriks, M.M.W.B. (author), Smilde, A.K. (author)Relations among hormone serum concentrations are complex and depend on various factors, including gender, age, body mass index, diurnal rhythms and secretion stochastics. Therefore, endocrine deviations from healthy homeostasis are not easily detected or understood. A generic method is presented for detecting regulatory relations between...article 2014
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Kamphuis, M. (author), Obenhuijsen, N.H. (author), van Dommelen, P. (author), van Buuren, S. (author), Verkerk, P.H. (author), TNO Kwaliteit van Leven (author)The main goal of this guideline for preventive child health care (PCHC) is to improve early detection of disorders that induce short stature. Based on research, evidence-based referral criteria for children aged 0-10 years with a short stature were formulated. These criteria are important for all professionals working with children, such as PCHC...article 2010
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Mihaescu, R. (author), Detmar, S.B. (author), Cornel, M.C. (author), van der Flier, W.M. (author), Heutink, P. (author), Hol, E.M. (author), Rikkert, M.G.M.O. (author), van Duijn, C.M. (author), Janssens, A.C.J.W. (author), TNO Kwaliteit van leven (author)Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...article 2010
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Geert Heidema, A. (author), Thissen, U. (author), Boer, J.M.A. (author), Bouwman, F.G. (author), Feskens, E.J.M. (author), Mariman, E.C.M. (author), TNO Kwaliteit van Leven (author)In this study, we applied the multivariate statistical tool Partial Least Squares (PLS) to analyze the relative importance of 83 plasma proteins in relation to coronary heart disease (CHD) mortality and the intermediate end points body mass index, HDL-cholesterol and total cholesterol. From a Dutch monitoring project for cardiovascular disease...article 2009
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Heijboer, A.C. (author), van den Hoek, A.M. (author), Parlevliet, E.T. (author), Havekes, L.M. (author), Romijn, J.A. (author), Pijl, H. (author), Corssmit, E.P.M. (author), TNO Kwaliteit van Leven (author)Aims/hypothesis: This study was conducted to evaluate the effects of ghrelin on insulin's capacity to suppress endogenous glucose production and promote glucose disposal in mice. To establish whether the growth hormone secretagogue (GHS) receptor can mediate the putative effect of ghrelin on the action of insulin, we also determined the...article 2006
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TNO Preventie en Gezondheid (author), van Tijn, D.A. (author), de Vijlder, J.J.M. (author), Verbeeten Jr., B. (author), Verkerk, P.H. (author), Vulsma, T. (author)Due to the high frequency of concurrent pituitary hormone deficiencies, congenital hypothyroidism (CH) of central origin (CH-C) is a life-threatening disorder. Yet only a minority of these patients are detected by neonatal CH screening programs worldwide. We conducted a prospective multicenter study involving a 2-yr cohort of neonatally...article 2005
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Tryfonidou, M.A. (author), Holl, M.S. (author), Stevenhagen, J.J. (author), Buurman, C.J. (author), Deluca, H.F. (author), Oosterlaken-Dijksterhuis, M.A. (author), van den Brom, W.E. (author), van Leeuwen, J.P.T.M. (author), Hazewinkel, H.A.W. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)The effects of excessive non-toxic dietary Vitamin D3 supplementation on Ca homeostasis with specific effects on endochondral ossification and skeletal remodeling were investigated in a group of growing Great Dane dogs supplemented with cholecalciferol (Vitamin D3; HVitD) versus a control group (CVitD) (1350 μg versus 11.4 μg Vitamin D3 per...article 2003
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Theunissen, N.C.M. (author), Kamp, G.A. (author), Koopman, H.M. (author), Zwinderman, K.A.H. (author), Vogels, T. (author), Wit, J.-M. (author), TNO Preventie en Gezondheid (author)Objective: Changes in health-related quality of life (HRQOL) and self-esteem were studied in children with idiopathic short stature (ISS) participating in a study on the effect of growth hormone treatment. Study design: Prepubertal children (n = 36) with ISS were randomly assigned to a treatment or control group. Children with ISS, their parents...article 2002
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