Searched for: subject:"Glucocorticoids"
(1 - 18 of 18)
document
Schaafsma, F.G. (author), Hulsegge, G. (author), de Jong, M.A. (author), Overvliet, J. (author), van Rossum, E.F.C. (author), Nieuwenhuijsen, K. (author)
Objectives: Workplace-based selective prevention of mental health problems currently relies on subjective evaluation of stress complaints. Hair cortisol captures chronic stress responses and could be a promising biomarker for the early identification of mental health problems. The objective was to provide an overview of the state-of-the-art...
article 2021
document
Fu, J. (author), Cuppen, B.V.J. (author), Welsing, P.M. (author), van Wietmarschen, H. (author), Harms, A.C. (author), Berger, R. (author), Koval, S. (author), Fritsch-Stork, R.D. (author), Bijlsma, J.W. (author), Hankemeier, T. (author), van der Greef, J. (author), Lafeber, F.P. (author)
Objective As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require...
article 2016
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Manenschijn, L. (author), van Rossum, E.F.C. (author), Jetten, A.M. (author), de Rooij, S.E. (author), van Munster, B.C. (author)
Delirium is the most common mental disorder at older age in hospitals after acute admission. The pathogenesis of delirium is largely unknown. Hyperactivity of the hypothalamic-pituitaryadrenal axis, leading to increased cortisol levels, has been suggested to play a role in the development of delirium. The effects of cortisol, the most important...
article 2011
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Finken, M.J.J. (author), TNO Kwaliteit van Leven (author)
Children born small-for-gestational-age (SGA) are at risk for short stature, and cardiovascular disease and type 2 diabetes in later life. There is some preliminary evidence for a similar phenotype in survivors of preterm birth. In contrast to children born SGA, preterm infants born appropriate-for-gestational-age who experienced neonatal growth...
doctoral thesis 2007
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van den Hauwe, O. (author), Campbell, K. (author), Crooks, S.R.H. (author), Schilt, R. (author), van Peteghem, C.H. (author), TNO Kwaliteit van Leven (author)
Within the framework of a European Union (EU) research project entitled "Food Safety Screening: Synthetic Glucocorticoids (QLK1-1999-00122)," an international interlaboratory ring test was organized to compare and evaluate different liquid chromatography/mass spectrometry (LC/MS) confirmatory methods that are applied in European monitoring...
article 2005
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Visser, J. (author), Lentjes, E. (author), Haspels, I. (author), Graffelman, W. (author), Blauw, B. (author), de Kloet, R. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Background: In this study we tested the hypothesis that the increased sensitivity to glucocorticoids in chronic fatigue syndrome (CFS)-patients can be attributed to an altered functioning of their glucocorticoid receptors (GR). Methods: For this purpose, affinity and distribution of the GR were studied in purified, peripheral blood mononuclear...
article 2001
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Verhoeven, A.C. (author), Boers, M. (author), te Koppele, J.M. (author), van der Laan, W.H. (author), Markusse, H.M. (author), Geusens, P. (author), van der Linden, S. (author), Gaubius Instituut (author)
Objectives. Exploration of bone metabolism changes at different levels of disease activity, both with and without oral corticosteroid therapy, and prediction of changes in joint damage and bone density from the observed changes in markers of bone turnover. Methods. Data analysis from a randomized clinical trial with 155 rheumatoid arthritis (RA)...
article 2001
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Visser, J. (author), Graffelman, W. (author), Blauw, B. (author), Haspels, I. (author), Lentjes, E. (author), de Kloet, R. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Several causes have been held responsible for the chronic fatigue syndrome (CFS), including an altered hypothalamus-pituitary-adrenal gland (HPA)-axis activity, viral infections and a reduced Th1 activity. Therefore, it was investigated whether the regulation of IL-10 is different in CFS. LPS-induced cytokine secretion in whole blood cultures...
article 2001
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Visser, J.T.J. (author), de Kloet, E. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
It is increasingly recognized that glucocortiocoids (GCs) can have subtle modulatory effects in immunoregulation rather than having generalized immunosuppressive effects. GCs suppress Th1 cells and cellular immunity, but may favor Th2 responses and humoral immunity. The chronic fatigue syndrome (CFS) appears to be associated with a disturbed HPA...
article 2000
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Department of Pharmacology (author), Langeveld-Wildschut, E.G. (author), Riedl, H. (author), Thepen, T. (author), Bihari, I.C. (author), Bruijnzeel, P.L.B. (author), Bruijnzeel-Koomen, C.A.F.M. (author)
Background: Pharmacologic studies in atopic eczema (AE) are difficult to standardize. Patients with AE differ in the stage of their skin disease (acute, subacute, chronic). Objective: This study was designed to assess macroscopic and microscopic effects of pretreatment with topical glucocortico-steroids (GCSs) and tar on the atopy patch test ...
article 2000
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Visser, J. (author), Blauw, B. (author), Hinloopen, B. (author), Brommer, E. (author), Ronald De Kloet, E. (author), Kluft, C. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
A disturbed hypothalamus-pituitary-adrenal gland axis and alterations at the immune system level have been observed in patients with chronic fatigue syndrome (CFS). Glucocorticoids are known to modulate T cell responses; therefore, purified CD4 T cells from CFS patients were studied to determine whether they have an altered sensitivity to...
article 1998
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Visser, J. (author), van Boxel-Dezaire, A. (author), Methorst, D. (author), Brunt, T. (author), de Kloet, E.R. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Antigen-presenting cells are thought to modulate the development of Th1 and Th2 cells by the secretion of interleukin-10 (IL-10) and IL-12. Because glucocorticoids (GC) favor the development of Th2 responses, we determined whether dexamethasone (DEX) and hydrocortisone (HC) have differential effects on lipopolysaccharide-induced IL-10 and IL-12...
article 1998
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Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A maj or determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its...
article 1998
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Noorman, F. (author), Braat, E.A.M. (author), Barrett-Bergshoeff, M.M. (author), Barbé, E. (author), van Leeuwen, A. (author), Lindeman, J. (author), Rijken, D.C. (author), TNO Preventie en Gezondheid (author)
Recently we developed mouse monocloual antibodies (mAb) against the isolated human 175-kDa mannose receptor. In the present study we tested whether these mAb are suitable for the detection of the mannose receptor on cultured macrophages using flow cytometry and on cells in human tissues using immunohistochemistry. Human monocytes did not react...
article 1997
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Nijhuis, E.W.P. (author), Oostervink, F. (author), Hinloopen, B. (author), Rozing, J. (author), Nagelkerken, L. (author), Gaubius Instituut TNO (author)
Peripheral blood mononuclear cells (PBMC) from 40 consecutive patients entering a screening program on cognitive impairment were studied in vitro with respect to their sensitivity to dexamethasone (DEX). Phytohemagglutinin-induced proliferation by PBMC from patients with senile dementia of the Alzheimer type (SDAT) was less sensitive to the...
article 1996
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Nijhuis, E.W.P. (author), Hinloopen, B. (author), van Lier, R.A.W. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
Human CD45RA+ ('naive') and CD45RO+ ('memory') CD4+ T cells were compared with respect to their sensitivity to dexamethasone (DEX). In three different activation pathways, i.e. (i) immobilized anti-CD3, (ii) immobilized anti-CD3 plus soluble anti-CD28 and (iii) soluble anti-CD2 plus soluble anti-CD28, naive CD4+ T cells appeared more sensitive...
article 1995
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Nijhuis, E.W.P. (author), Hinloopen, B. (author), Odding, J. (author), Nagelkerken, L. (author), TNO Preventie en Gezondheid (author)
The suppressive effect of the glucocorticoid dexamethasone (DEX) on purified CD4+ T cells was found to depend on the activation pathway. In contrast to anti-CD3- or PHA-induced T cell proliferation, the alternative pathway of T cell activation, i.e., through anti-CD2 and anti-CD28, appeared largely resistant to DEX. By titrating anti-CD28 or the...
article 1994
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Nijhuis, E. (author), Hinloopen, B. (author), van Duijn, C. (author), Hofman, A. (author), Rozing, J. (author), Nagelkerken, L. (author), Section of Immunology, Inst. of Aging and Vascular Research, TNO, Leiden, Netherlands TNO Preventie en Gezondheid (author)
Cortisol levels in patients with Alzheimer's disease (AD) are relatively unaffected by a challenge with dexamethasone (DEX) in vivo. The present study demonstrates that DEX is less inhibitory for phytohemagglutinin (PHA)-induced T cell proliferation in AD patients as compared to age-matched controls. Since no significant differences were found...
article 1994
Searched for: subject:"Glucocorticoids"
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