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Elliott, C.T. (author), Baxter, G.A. (author), Hewitt, S.A. (author), Arts, C.J.M. (author), van Baak, M. (author), Hellenäs, K.-E. (author), Johannson, A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The drug salbutamol (SBL) is a β-agonist that may be used illegally as an animal growth promoter. SBL is also a good example of a drug which is excreted in the form of glucuronides and sulfates. Such metabolites cause complexities in analysing for the presence of drug residues. In the majority of cases a process of deconjugation and sample clean...article 1998
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Hankemeier, T. (author), Louter, A.J.H. (author), Dallüge, J. (author), Vreuls, R.J.J. (author), Brinkman, U.A.T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A drying cartridge was used and optimized for the in-line elimination of water from the desorption eluent in on-line solid phase extraction-gas chromatography (SPE-GC). The cartridge is essentially a small stainless- steel precolumn packed with a drying agent which can be regenerated by simultaneous heating and purging with a moisture-free gas....article 1998
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Osman, A.M. (author), Posthumus, M.A. (author), Veeger, C. (author), van Bladeren, P.J. (author), Laane, C. (author), Rietjens, I.M.C.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This study reports the microperoxidase-8 (MP8)/H2O2-catalyzed dehalogenation of pentafluorophenol and pentachlorophenol, compounds whose toxic effects and persistence in the environment are well documented. The primary products of this dehalogenation reaction appear to be the corresponding tetrahalo-p-benzoquinones. Under the conditions used,...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), van Puymbroeck, M. (author), Kuilman, M.E.M. (author), Maas, R.F.M. (author), Witkamp, R.F. (author), Leyssens, L. (author), van der Zande, D.J.M. (author), Gelan, J. (author), Raus, J. (author)17alpha-Boldenone (17alpha-BOL) and/or 17beta-boldenone (17beta-BOL) appear occasionally in fecal matter of cattle. In addition to 17alpha-BOL, a whole array of boldenone related substances can be found in the same samples. In vitro experiments with microsomal liver preparations and isolated hepatocytes combined with the excretion profiles found...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author), de Brabander, H.F. (author), de Wasch, K. (author), van Ginkel, L.A. (author), Sterk, S.S. (author), Blokland, M.H. (author), Delahaut, Ph. (author), Taillieu, X. (author), Dubois, M. (author), Arts, C.J.M. (author), van Baak, M.J. (author), Gramberg, L.G. (author), Schilt, R. (author), van Bennekom, E.O. (author), Courtheyn, D. (author), Vercammen, J. (author), Witkamp, R.F. (author)The European Union banned the use of anabolic steroids for cattle fattening in 1988. Analytical techniques able to detect trace amounts of the parent drugs and their metabolites are mandatory for the control of abuse. Stanozolol (Stan) is an anabolic steroid that is often found in injection sites and cocktails. However, it has never been...article 1998
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Bessems, J.G.M. (author), te Koppele, J.M. (author), van Dijk, P.A. (author), van Stee, L.L.P. (author), Commandeur, J.N.M. (author), Vermeulen, N.P.E. (author), Leiden/Amsterdam Ctr. for Drug Res., Division of Molecular Toxicology, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, Netherlands Dept. Vasc. Connective Tissue Res TNO Preventie en Gezondheid (author)1. The cytochrome P450-dependent binding of paracetamol and a series of 3,5-disubstituted paracetamol analogues (R = -F, -Cl, -Br, -I, -C(H)3, -C2H5, -iC3H7) have been determined with β-naphthoflavone (βNF)-induced rat liver microsomes and produced reverse type I spectral changes. K(s,app) varied from 0.14 mM for 3,5-diiC3H7-paracetamol to 2.8...article 1996
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Vink, M. (author), van der Poll, J.M. (author), TNO Voeding (author)The development of a multi-residue method for the determination of eight polar acidic herbicides (MCPA, MCPB, mecoprop, 2,4-D, dichlorprop, bentazone, dicamba and dikegulac) in surface water is described. The method involves an off-line solid-phase extraction (SPE) procedure prior to instrumental analysis. The herbicides are isolated on an SPE C...article 1996
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Degenhardt, C.E.A.M. (author), Kientz, C.E. (author), TNO Prins Maurits Laboratorium (author)The use of large volume injections has been studied for the verification of intact organophosphorus chemical warfare agents in water samples. As the use of ethyl acetate caused severe detection problems new potential solvents were evaluated. With the developed procedure, the nerve agents sarin, tabun, soman, DFP and VX can be determined in...article 1996
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Noort, D. (author), Verheij, E.R. (author), Hulst, A.G. (author), de Jong, L.P.A. (author), Benschop, H.P. (author), Prins Maurits Laboratorium TNO TNO Voeding (author)In this paper we describe the use of tandem mass spectrometry to identify modified sites in human hemoglobin after in vitro exposure to bis(2- chloroethyl) sulfide (sulfur mustard). Globin isolated from human whole blood which had been exposed to sulfur mustard was degraded with trypsin, and the digests were analyzed by micro LC/MS. Alkylated...article 1996
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van Doorn, C. (author), Vink, M. (author), van der Poll, J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A gas chromatographic method, with electron capture detection and mass spectrometric confirmation, is described for the determination of chlorothalonil and its metabolite 4-hydroxy-2,5,6-trichloroisophtalonitrile (HTI) in water samples. Water is saturated with sodium chloride and acidified to pH < 2 with dilute sulfuric acid. After extraction...article 1995
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Feron, V.J. (author), Jetten, J. (author), de Kruijf, N. (author), van den Berg, F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)As part of a multi-client project, the potential public health risks of the reuse of polyethylene terephthalate (PET) refillable bottles (PRBs) following possible misuse has been investigated. Participants in the project provided data and information from previous studies conducted independently at contract laboratories. These studies were...article 1994
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Leenheers, L.H. (author), van Breugel, D.C. (author), Ravensberg, J.C. (author), Meuling, W.J.A. (author), Jongen, M.J.M. (author), Medisch Biologisch Laboratorium TNO (author)An analytical method for the assessment of the exposure of workers to the pesticide propoxur through biological monitoring has been developed. This study was part of a survey of occupational exposure to pesticides used in greenhouses for the growing of ornamental plants. In order to assess the actual absorbed amount of propoxur in the body, an...article 1992
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- Kientz, C.E. (author), Prins Maurits Laboratorium TNO (author) doctoral thesis 1992
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Brouwer, R. (author), Marquart, H. (author), de Mik, G. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO Instituut CIVO-Toxicologie en Voeding TNO (author)On 18 farms for rose culture in greenhouses in The Netherlands, dermal exposure of hands and forearms to abamectin (avermectin B1), dodemorph (4- cyclododecyl-2,6-dimethylmorpholinium acetate) and bupirimate (5-butyl-2- (ethylamino)-6-methyl-4-pyrimidinyl dimethylsulphate) was measured during crop activities. Dermal exposure during cutting (75...article 1992
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- van Ingen, R.H.M. (author), Nijssen, L.M. (author), van den Berg, F. (author), Maarse, H. (author), Centraal instituut voor voedingsonderzoek TNO (author) article 1987
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Toxicokinetics of the four stereoisomers of soman in the rat, guinea pig, and marmoset. Final reportPrins Maurits Laboratorium TNO (author), Benschop, H.P. (author), de Jong, L.P.A. (author)Methods for stabilization and work up of the soman isomers in blood and other biological materials were developed. In combination with chiral gas chromatography, a verified minimum detectable 8.3 pM concentration of each highly toxic C(±)P(-)-soman isomer in blood can be measured. Toxicokinetic investigations involved: 1. Measurement of the...report 1987
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Etievant, P. (author), Maarse, H. (author), van den Berg, F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A number of headspace techniques have been compared, using a standard solution containing 12 compounds and a wine sample, viz.: (1) purge and cold trap injection; (2) dynamic headspace combined with liquidliquid extraction; (3) static headspace with and without preconcentration; (4) direct liquid injection. The sensitivity, reproducibility and...article 1986
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Mulders, Ed.J. (author), van Impelen-Peek, H.A.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Samples of barley, wheat and maize were analysed for deoxynivalenol (DON). Samples were extracted with aqueous chloroform-ethanol. The extract was purified by column chromatography on silica gel. DON was derivatised with heptafluorobutyric (HFB) acid anhydride. The glassware was silylated to prevent deterioration of the HFB derivative, which...article 1986
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- Centraal instituut voor voedingsonderzoek TNO (author), Núñez, A.J. (author), Maarse, H. (author) article 1986
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Benschop, H.P. (author), Berends, F. (author), de Jong, L.P.A. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: soman, 96-64-0; Organophosphorus Compounds; Soman, 96-64-0article 1981