Searched for: subject%3A%22Gas%255C%2Bchromatography%22
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van der Schans, M.J. (author)
Chemical warfare agents (CWAs) are the most toxic compounds that have ever been produced. In order to develop medical countermeasures against the effects of these agents, analytical procedures to analyze these agents in their intact form in biological matrices are essential for a better understanding of the toxicological process. Although the...
bookPart 2020
document
den Uil, H. (author), Wittkampf, S.A. (author)
ECN has developed a simple and inexpensive method to prevent clogging of dust in capillary columns of mass spectrometers or gas chromatographs. In some processes there are dust particles present in the process gas. The method developed by ECN is a smart solution that helps to prevent that dust particles end up in the analyzer.
other 2016
document
Bezemer, K.D.B. (author), Koeberg, M. (author), van der Heijden, A.E.D.M. (author), van Driel, C.A. (author), Blaga, C. (author), Bruinsma, J. (author), van Asten, A.C. (author)
Studying links between triacetone triperoxide (TATP) samples from crime scenes and suspects can assist in criminal investigations. Isotope ratio mass spectrometry (IRMS) and gas chromatography (GC)-IRMS were used to measure the isotopic compositions of TATP and its precursors acetone and hydrogen peroxide. In total, 31 TATP samples were...
article 2016
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Koster, S. (author), Leeman, W.R. (author), Verheij, E.R. (author), Dutman, A.E. (author), van Stee, L.L.P. (author), Munch Nielsen, L. (author), Ronsmans, S. (author), Noteborn, H. (author), Krul, L. (author)
A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult...
article 2015
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Brust, H. (author), Willemse, S. (author), Zeng, T. (author), van Asten, A. (author), Koeberg, M. (author), van der Heijden, A.E.D.M. (author), Bolck, A. (author), Schoenmakers, P. (author)
In this work, a reliable and robust vacuum-outlet gas chromatography-mass spectrometry (GC-MS) method is introduced for the identification and quantification of impurities in trinitrotoluene (TNT). Vacuum-outlet GC-MS allows for short analysis times the analysis of impurities in TNT was performed in 4. min. This study shows that impurity...
article 2014
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Ramautar, R. (author), Berger, R. (author), van der Greef, J. (author), Hankemeier, T. (author)
Metabolomics provides a direct functional read-out of the physiological status of an organism and is in principle ideally suited to describe someone's health status. Whereas only a limited number of small metabolites are used in the clinics, in inborn errors of metabolism an extensive repertoire of metabolites are used as biomarkers. We discuss...
article 2013
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Koek, M.M. (author), van der Kloet, F.M. (author), Kleemann, R. (author), Kooistra, T. (author), Verheij, E.R. (author), Hankemeier, T. (author)
Due to the complexity of typical metabolomics samples and the many steps required to obtain quantitative data in GC × GC-MS consisting of deconvolution, peak picking, peak merging, and integration, the unbiased non-target quantification of GC × GC-MS data still poses a major challenge in metabolomics analysis. The feasibility of using...
article 2011
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van Batenburg, M.F. (author), Coulier, L. (author), van Eeuwijk, F. (author), Smilde, A.K. (author), Westerhuis, J.A. (author)
In the field of metabolomics, hundreds of metabolites are measured simultaneously by analytical platforms such as gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS) and NMR to obtain their concentration levels in a reliable way. Analytical repeatability (intrabatch precision) is a common figure of merit...
article 2011
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Koek, M.M. (author), Jellema, R.H. (author), van der Greef, J. (author), Tas, A.C. (author), Hankemeier, T. (author)
Metabolomics involves the unbiased quantitative and qualitative analysis of the complete set of metabolites present in cells, body fluids and tissues (the metabolome). By analyzing differences between metabolomes using biostatistics (multivariate data analysis; pattern recognition), metabolites relevant to a specific phenotypic characteristic...
article 2011
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van der Meer, J.A. (author), Trap, H.C. (author), Noort, D. (author), van der Schans, M.J. (author), TNO Defensie en Veiligheid (author)
Recently, several methods have been developed to verify exposure to nerve agents. Most of these methods, such as the fluoride reactivation technique and the analysis of inhibited phosphonylated butyrylcholinesterase (BuChE), are based on mass spectrometry. The high specificity of the mass spectrometer might also imply a disadvantage, because the...
article 2010
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Koek, M.M. (author), Muilwijk, B. (author), van Stee, L.L.P. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
article 2008
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Ehlert, K.A. (author), Beumer, C.W.E. (author), Groot, M.C.E. (author), TNO Kwaliteit van Leven (author)
A comprehensive migration database was established for bisphenol A from polycarbonate baby bottles into water during exposure to microwave heating. Eighteen different brands of polycarbonate baby bottles sold in Europe were collected. Initial residual content of bisphenol A and migration after microwave heating were determined. Residual content...
article 2008
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de Weert, J. (author), de la Cal, A. (author), van den Berg, H. (author), Murk, A. (author), Langenhoff, A. (author), Rijnaarts, H. (author), Grotenhuis, T. (author), TNO Bouw en Ondergrond (author)
The surfactant nonylphenol (NP) is an endocrine-disrupting compound that is widely spread throughout the environment. Although environmental risk assessments are based on total NP concentrations, only the bioavailable fraction posses an environmental risk. The present study describes the bioavailability and biodegradability of NP over time in...
article 2008
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Mol, H.G.J. (author), Rooseboom, A. (author), van Dam, R. (author), Roding, M. (author), Arondeus, K. (author), Sunarto, S. (author), TNO Kwaliteit van Leven (author)
The ethyl acetate-based multi-residue method for determination of pesticide residues in produce has been modified for gas chromatographic (GC) analysis by implementation of dispersive solid-phase extraction (using primary-secondary amine and graphitized carbon black) and large-volume (20 μL) injection. The same extract, before clean-up and after...
article 2007
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Werf, M.J.v.d. (author), Overkamp, K.M. (author), Muilwijk, B. (author), Coulier, L. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
Achieving metabolome data with satisfactory coverage is a formidable challenge in metabolomics because metabolites are a chemically highly diverse group of compounds. Here we present a strategy for the development of an advanced analytical platform that allows the comprehensive analysis of microbial metabolomes. Our approach started with in...
article 2007
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Kerkdijk, H. (author), Mol, H.G.J. (author), van der Nagel, B. (author), TNO Kwaliteit van Leven (author)
A new concept for cleanup, based on volume overloading of the cleanup column, has been developed for on-line coupling of gel permeation chromatography (GPC), solid-phase extraction (SPE), or both, to gas chromatography (GC). The principle is outlined and the applicability demonstrated by the determination of pesticide residues in food matrixes...
article 2007
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van der Greef, J. (author), Hankemeier, T. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)
Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular...
article 2006
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Gao, K. (author), Xu, A. (author), Krul, C.A.M. (author), Venema, K. (author), Liu, Y. (author), Niu, Y. (author), Lu, J. (author), Bensoussan, L. (author), Seeram, N.P. (author), Heber, D. (author), Henning, S.M. (author), TNO Kwaliteit van Leven (author)
Dietary flavonoids are poorly absorbed from the gastrointestinal tract. Colonic bacteria convert flavonoids into smaller phenolic acids (PA), which can be absorbed into the circulation and may contribute to the chemopreventive activity of the parent compounds. The purpose of our study was to determine whether flavonoids from green and black tea ...
article 2006
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Le Bizec, B. (author), Courant, F. (author), Gaudin, I. (author), Bichon, E. (author), Destrez, B. (author), Schilt, R. (author), Draisci, R. (author), Monteau, F. (author), André, F. (author), TNO Kwaliteit van Leven (author)
Boldenone is an androgenic steroid that improves the growth and food conversion in food producing animals. In most countries worldwide, this anabolic steroid is forbidden for meat production. Until recently, the control of its illegal use was based either on 17β-boldenone or 17α-boldenone (its main metabolite in cattle) identification in edible...
article 2006
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Koek, M.M. (author), Muilwijk, B. (author), van der Werf, M.J. (author), Hankemeier, T. (author), TNO Kwaliteit van Leven (author)
An analytical method was set up suitable for the analysis of microbial metabolomes, consisting of an oximation and silylation derivatization reaction and subsequent analysis by gas chromatography coupled to mass spectrometry. Microbial matrixes contain many compounds that potentially interfere with either the derivatization procedure or analysis...
article 2006
Searched for: subject%3A%22Gas%255C%2Bchromatography%22
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