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Männistö, S. (author), Smith-Warner, S.A. (author), Spiegelman, D. (author), Albanes, D. (author), Anderson, K. (author), van den Brandt, P.A. (author), Cerhan, J.R. (author), Colditz, G. (author), Feskanich, D. (author), Freudenheim, J.L. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Graham, S. (author), Miller, A.B. (author), Rohan, T.E. (author), Virtamo, J. (author), Willett, W.C. (author), Hunter, D.J. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the...article 2004
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- van Ommen, B. (author), TNO Voeding (author) article 2004
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Jansen, M.C.J.F. (author), Bueno-De-Mesquita, H.B. (author), Feskens, E.J.M. (author), Streppel, M.T. (author), Kok, F.J. (author), Kromhout, D. (author), TNO Voeding (author)The recommendation for fruit and vegetable intake includes eating a certain quantity as well as a variety. The evidence for eating a variety is limited. We examined the association with cancer in a prospective cohort study among 730 Dutch men aged 65-84 yr followed for 10 years, resulting in 138 cancer cases. The quantity of fruits and...article 2004
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Lambert, J. (author), Agostoni, C. (author), Elmadfa, I. (author), Hulshof, K. (author), Krause, E. (author), Livingstone, B. (author), Socha, P. (author), Pannemans, D. (author), Samartín, S. (author)The objective of this project was to collect and evaluate data on nutrient intake and status across Europe and to ascertain whether any trends could be identified. Surveys of dietary intake and status were collected from across Europe by literature search and personal contact with country experts. Surveys that satisfied a defined set of criteria...article 2004
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López-Cervantes, L. (author), Sánchez-Machado, D.I. (author), Pastorelli, S. (author), Rijk, R. (author), Paseiro-Losada, P. (author), TNO Voeding (author)The behaviour of two commercial oxygen-scavenging products with respect to migration of active ingredients into foodstuffs was investigated. Migrants were identified, and by using appropriate analytical methods, migration was determined in a variety of liquid, solid or gelled food simulants and foods. Simulants were chosen to cover a range of...article 2003
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Hoppe, P.P. (author), Krämer, K. (author), van den Berg, H. (author), Steenge, G. (author), van Vliet, T. (author), TNO Voeding (author)Background: Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. Aim of the study: To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel trial. Methods: Three...article 2003
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Zerdin, K. (author), Rooney, M.L. (author), Vermuë, J. (author), TNO Voeding (author)A storage study of orange juice packed in oxygen scavenging (OS) film and oxygen barrier film was conducted to determine the extent of ascorbic acid loss due to oxygen as a function of time and temperature. The initial concentration of ascorbic acid in the orange juice was 374 mg/l and this was found to decrease by 74 and 104 mg/l after 3 days...article 2003
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Arkbåge, K. (author), Verwei, M. (author), Havenaar, R. (author), Witthöft, C. (author), TNO Voeding (author)Milk products are only moderate sources of folate. Nevertheless, they are of interest due to their content of folate-binding proteins (FBP), which in some studies have been reported to increase folate bioavailability. The effect of FBP on folate bioavailability has been widely discussed. The aim of this study was to investigate the...article 2003
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TNO Voeding (author), Venema, K. (author), van Nuenen, M.H.M.C. (author), van den Heuvel, E.G. (author), Pool, W. (author), van der Vossen, J.M.B.M. (author)The objective of this study was to compare the in vivo effect of lactulose on faecal parameters with the effect in a dynamic, computer-controlled in vitro model of the proximal large intestine (TIM-2). Faecal samples from 10 human volunteers collected before (non-adapted) and after 1 week of treatment (10 g/day) with lactulose (lactulose-adapted...article 2003
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TNO Voeding (author), Vente-Spreeuwenberg, M.A.M. (author), Verdonk, J.M.A.J. (author), Verstegen, M.W.A. (author), Beynen, A.C. (author)The present study was designed to evaluate the differential effects of dietary glucose, lactose and starch on small-intestinal morphology, organ weights, pH of chyme and haptoglobin levels in blood plasma of weaned piglets. It was hypothesised that lactose consumption would ameliorate the weaning-induced decrease in gut integrity. A total of...article 2003
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TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author), Kiely, M. (author), Faughnan, M. (author), Wähälä, K. (author), Brants, H. (author), Mulligan, A. (author)The objective of the Vegetal Estrogens in Nutrition and the Skeleton (VENUS) project was to evaluate existing data on dietary exposure to compounds with oestrogenic and anti-oestrogenic effects present in plant foods as constituents or contaminants, and to identify and disseminate in vitro and in vivo methodologies to analyse the effects of such...article 2003
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Centraal Instituut voor Voedingsonderzoek TNO (author), van Erp-Baart, M.A.J. (author), Brants, H.A.M. (author), Kiely, M. (author), Mulligan, A. (author), Turrini, A. (author), Sermoneta, C. (author), Kilkkinen, A. (author), Valsta, L.M. (author)The aim of this study was to identify the level of isoflavone intake (total isoflavones, daidzein and genistein) in four European countries: Ireland, Italy, The Netherlands and the UK. For this purpose national food composition databases of isoflavone content were created in a comparable way, using the Vegetal Estrogens in Nutrition and the...article 2003
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Kroes, R. (author), Müller, D. (author), Lambe, J. (author), Löwik, M.R.H. (author), van Klaveren, J. (author), Kleiner, J. (author), Massey, R. (author), Mayer, S. (author), Urieta, I. (author), Verger, P. (author), Visconti, A. (author)Exposure assessment is one of the key parts of the risk assessment process. Only intake of toxicologically significant amounts can lead to adverse health effects even for a relatively toxic substance. In the case of chemicals in foods this is based on three major aspects: (i) how to determine quantitatively the presence of a chemical in...article 2002
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Sierksma, A. (author), van der Gaag, M.S. (author), Kluft, C. (author), Hendriks, H.F.J. (author), TNO Voeding (author)Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Design: Randomized, diet-controlled, cross-over study. Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. Subjects: Ten middle-aged men and 10 postmenopausal women, all...article 2002
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Voorrips, L.E. (author), Goldbohm, R.A. (author), Brants, H.A.M. (author), van Poppel, G.A.F.C. (author), Sturmans, F. (author), Hermus, R.J.J. (author), van den Brandt, P.A. (author)Many studies have reported inverse associations between vegetable and fruit consumption and lung cancer risk. The aim of the present study was to elucidate the role of several antioxidants and folate in this relationship. In the Netherlands Cohort Study on Diet and Cancer, 58,279 men of ages 55-69 years at baseline in 1986 returned a...article 2000
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Beemster, C.J.M. (author), Hulshof, K.F.A.M. (author), Breedveld, B.C. (author), Westenbrink, S. (author)In 1987-1988, the first Dutch National Food Consumption Survey (DNFCS) was carried out; similar surveys were conducted in 1992 and 1997-1998. In each survey, food consumption data were converted into energy and nutrients using the most up-to-date version of the Dutch food composition table. To enable valid comparisons of nutrient intake over...article 2000
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Knippels, L.M.J. (author), Penninks, A.H. (author), Houben, G.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Background: One of the major factors that may have negatively affected the results of many oral sensitization studies in animals has been unscheduled dietary preexposure of the test animals or their parental generations to the antigen under investigation. Objective: The influence of dietary preexposure to soy protein on oral sensitization...article 1998
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Finglas, P.M. (author), van den Berg, H. (author), Froidmont de- Görtz, I. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Accurate methods for the determination of vitamins in food are required for nutritional labelling, and for the production of food composition data for nutritional research on relationships between diet and health. The Standards, Measurement and Testing Programme of the European Commission is supporting a collaborative project involving 48...article 1996
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Hulshof, K.F.A.M. (author), Beemster, C.J.M. (author), Westenbrink, S. (author), Löwik, M.R.H. (author), TNO Voeding (author)In 1987-1988, the first Dutch National Food Consumption Survey (DNFCS) was conducted among 5898 subjects, aged 1-85 years. In 1992, the second survey was carried out among 6218 subjects, aged 1-92 years. Data of the first DNFCS were converted into energy and nutrients with the 1986-1987 version of The Netherlands nutrient databank (NEVO). The...article 1996
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van den Berg, H. (author), van Schaik, F. (author), Finglas, P.M. (author), de Froidmont-Görtz, I. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)An intercomparison study on the determination of vitamin B-1, B-2 and B-6 was performed as part of the EU MAT project involving 16 laboratories. Each laboratory was requested to analyse three different food samples (lyophilized pig's liver, mixed vegetables and wholemeal flour, respectively) using their 'in-house' method as well as an 'optimal...article 1996