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Mulder, P.P.J. (author), Zuidema, T. (author), Keestra, N.G.M. (author), Kooij, P.J.F. (author), Elbers, I.J.W. (author), van Rhijn, J.A. (author), TNO Kwaliteit van Leven (author)A method is described for the identification and quantitative determination of 3,5-dinitrosalicylic acid hydrazide (DSH), the marker residue of nifursol metabolites in poultry (turkey, broiler) muscle and liver tissue. The method is based on the acid-catalysed hydrolysis of tissue-bound metabolites to free DSH and in situ derivatisation with 2...article 2005
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Boonzaaijer, G. (author), Bobeldijk, I. (author), van Osenbruggen, W.A. (author), TNO Kwaliteit van Leven (author)A reliable method for the determination of patulin in apple juice, apple puree and apples was developed using two clean-up steps and high performance liquid chromatography and diode array (HPLC-DAD) analysis. Baseline separation from hydroxymethyl furfural (HMF) was obtained. The performance characteristics of the method were determined at four...article 2005
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Begley, T. (author), Castle, L. (author), Feigenbaum, A. (author), Franz, R. (author), Hinrichs, K. (author), Lickly, T. (author), Mercea, P. (author), Milana, M. (author), O'Brien, A. (author), Rebre, S. (author), Rijk, R. (author), Piringer, O. (author), TNO Kwaliteit van Leven TNO Voeding (author)Materials and articles intended to come into contact with food must be shown to be safe because they might interact with food during processing, storage and the transportation of foodstuffs. Framework Directive 89/109/EEC and its related specific Directives provide this safety basis for the protection of the consumer against inadmissible...article 2005
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Feigenbaum, A. (author), Dole, P. (author), Aucejo, S. (author), Dainelli, D. (author), de la Cruz Garcia, C. (author), Hankemeier, T. (author), N'Gono, Y. (author), Papaspyrides, C.D. (author), Paseiro, P. (author), Pastorelli, S. (author), Pavlidou, S. (author), Pennarun, P.Y. (author), Saillard, P. (author), Vidal, L. (author), Vitrac, O. (author), Voulzatis, Y. (author), TNO Kwaliteit van Leven (author)Functional barriers are multilayer structures deemed to prevent migration of some chemicals released by food-contact materials into food. In the area of plastics packaging, different migration behaviours of mono- and multilayer structures are assessed in terms of lag time and of their influence of the solubility of the migrants in food simulants...article 2005
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Avantaggiato, G. (author), Havenaar, R. (author), Visconti, A. (author), TNO Voeding (author)In vitro screening of 14 adsorbent materials, including some commercial products used to detoxify Fusarium-mycotoxins, were tested in the pH range of 3-8 for deoxynivalenol (DON)- and nivalenol (NIV)-binding ability. Only activated carbon showed to be effective with binding capacities of 35.1 μmol and 8.8 μmol DON and NIV/g adsorbent,...article 2004
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Blankvoort, B.M.G. (author), Aarts, J.M.M.J.G. (author), Schilt, R. (author), Geerdink, P. (author), Spenkelink, B. (author), Rodenburg, R.J.T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Despite a ban by the European Union, the use of anabolic steroids and repartitioning agents in cattle is still occasionally observed. Due to continuing improvements in analytical techniques, very low detection limits for individual compounds have been achieved. In response to these developments, cocktails composed of several steroids have been...article 2003
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López-Cervantes, L. (author), Sánchez-Machado, D.I. (author), Pastorelli, S. (author), Rijk, R. (author), Paseiro-Losada, P. (author), TNO Voeding (author)The behaviour of two commercial oxygen-scavenging products with respect to migration of active ingredients into foodstuffs was investigated. Migrants were identified, and by using appropriate analytical methods, migration was determined in a variety of liquid, solid or gelled food simulants and foods. Simulants were chosen to cover a range of...article 2003
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Avantaggiato, G. (author), Havenaar, R. (author), Visconti, A. (author), TNO Voeding (author)A novel approach is presented herein to study the intestinal absorption of mycotoxins by using a laboratory model that mimics the metabolic processes of the gastrointestinal (GI) tract of healthy pigs. This model was used to evaluate the small-intestinal absorption of zearalenone from contaminated wheat (4.1 mg/kg) and the effectiveness of...article 2003
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de Jong, A.E.I. (author), Eijhusen, G.P. (author), Brouwer-Post, E.J.F. (author), Grand, M. (author), Johansson, T. (author), Kärkkäinen, T. (author), Marugg, J. (author), in 't Veld, P.H. (author), Warmerdam, F.H.M. (author), Wörner, G. (author), Zicavo, A. (author), Rombouts, F.M. (author), Beumer, R.R. (author)Many media have been developed to enumerate Clostridium perfringens from foods. In this study, six media [iron sulfite (IS) agar, tryptose sulfite cycloserine (TSC) agar, Shahidi Ferguson perfringens (SFP) agar, sulfite cycloserine azide (SCA), differential clostridial agar (DCA), and oleandomycin polymyxin sulfadiazine perfringens (OPSP) agar]...article 2003
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Kroes, R. (author), Müller, D. (author), Lambe, J. (author), Löwik, M.R.H. (author), van Klaveren, J. (author), Kleiner, J. (author), Massey, R. (author), Mayer, S. (author), Urieta, I. (author), Verger, P. (author), Visconti, A. (author)Exposure assessment is one of the key parts of the risk assessment process. Only intake of toxicologically significant amounts can lead to adverse health effects even for a relatively toxic substance. In the case of chemicals in foods this is based on three major aspects: (i) how to determine quantitatively the presence of a chemical in...article 2002
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Jetten, J. (author), de Kruijf, N. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The aim of the project was to develop a comprehensive package of quality assurance criteria for use by the industry and by regulatory authorities to ensure the quality and safety-in-use (sensory, microbiological and chemical safety) of reused plastics for food packaging. The paper describes the investigations into potential adulteration effects...article 2002
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Helmroth, I.E. (author), Dekker, M. (author), Hankemeier, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The effect of solvent absorption on additive migration was studied by relating the diffusion coefficient (D) of Irganox 1076 to the maximum solvent absorption of different solvents in low-density polyethylene (LDPE) film. Solvents tested were ethanol, isopropanol, isooctane, ethylacetate, cyclohexane, tributyrin, tricaprylin and olive oil....article 2002
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van den Brandt, P. (author), Voorrips, L. (author), Hertz-Picciotto, I. (author), Shuker, D. (author), Boeing, H. (author), Speijers, G. (author), Guittard, C. (author), Kleiner, J. (author), Knowles, M. (author), Wolk, A. (author), Goldbohm, A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Epidemiologic studies directly contribute data on risk (or benefit) in humans as the investigated species, and in the full food intake range normally encountered by humans. This paper starts with introducing the epidemiologic approach, followed by a discussion of perceived differences between toxicological and epidemiologic risk assessment....article 2002
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de Kruijf, N. (author), van Beest, M. (author), Rijk, R. (author), Sipiläinen-Malm, T. (author), Paseiro Losada, P. (author), de Meulenaer, B. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)Changes in the way foods are produced, distributed, stored and retailed, reflecting the continuing increase in consumer demands for improved quality and extended shelf-life for packaged foods, are placing ever-greater demands on the performance of food packaging. Consumers want to be assured that the packaging is fulfilling its function of...article 2002
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Magos, L. (author), TNO BIBRA International Ltd, Woodmansterne Rd, Carshalton, Surrey SM5 4DS, United Kingdom Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Chemicals/CAS: Biological Products; Ethylmercury Compounds; Food Additives; Pharmaceutical Preparations; Preservatives, Pharmaceutical; Thimerosal, 54-64-8article 2001
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Prinsen, M.K. (author), Gouko, N. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)In Japan there is growing concern about the possible adverse effects of consumption of food from styrene containers (mainly those made from polystyrene paper) due to the alleged oestrogenic activity of styrene oligomers (dimers and trimers), which may migrate into the food. To examine the possible oestrogenic activity of styrene dimers and...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Crews, H. (author), Alink, G. (author), Andersen, R. (author), Braesco, V. (author), Holst, B. (author), Maiani, G. (author), Ovesen, L. (author), Scotter, M. (author), Solfrizzo, M. (author), van den Berg, R. (author), Verhagen, H. (author), Williamson, G. (author)In this review many examples are given of the complexities involved in using some biomarkers in relation to assessing the effects of dietary exposure, when there is frequently a need to determine changes following long-term low level exposure to dietary components. These range from understanding why the biomarker might be valuable and how best...article 2001
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Simal-Gándara, J. (author), Sarria-Vidal, M. (author), Rijk, M.A.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A liquid chromatographic method with evaporative mass detection (EMD) is described for the determination of paraffins in food contact materials that do not contain polyolefin oligomers, or paraffins migrating from these materials into fatty food simulants or certain simple foods. A normal-phase column operating at maximum column efficiency...article 2000
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Notermans, S. (author), Hoornstra, E. (author), TNO Voeding (author)Risk assessment is increasingly used as a scientific process to assess the potential for adverse health effects to occur and as a basis for management of unacceptable risks. For each risk assessment activity, the purpose of the assessment should be clearly stated. For Listeria monocytogenes, the purpose of risk assessment may be providing...article 2000
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Löwik, M.R.H. (author), Hulshof, K.F.A.M. (author), Brussaard, J.H. (author), Kistemaker, C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Food chemical risk management needs, among other things, assessment of exposure. For dietary intake food consumption surveys are the data source to be used. One complicating factor in the usage of these data is the dependence of dietary intake estimates on the time frame of assessment. Central to this time dependence is the within-subject...article 1999