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Jonker, D. (author), Lina, B.A.R. (author), Kozianowski, G. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)The potential subchronic oral toxicity of isomaltulose (Palatinose®) was examined by administering this substance in the diet to groups of 20 male and 20 female Wistar rats at levels of 0, 2.5, 5 and 10% for 13 consecutive weeks. Daily clinical observations, body weight, food conversion efficiency, food and water consumption were not affected at...article 2002
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Konings, E.J.M. (author), Troost, F.J. (author), Castenmiller, J.J.M. (author), Roomans, H.H.S. (author), van den Brandt, P.A. (author), Saris, W.H.M. (author)Our knowledge on the absorption of folate is incomplete. The deconjugation process as a possible limiting factor in the absorption of folates was investigated. The study also attempted to validate the use of the area under the serum response curve (AUC) from food compared with folic acid as a proxy variable for food folate bioavailability....article 2002
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TNO Voeding (author), van Duijn, G. (author), van Biert, R. (author), Bleeker-Marcelis, H. (author), van Boeijen, I. (author), Adan, A.J. (author), Jhakrie, S. (author), Hessing, M. (author)According to European Commission (EC) Regulation 1139/98, foods and food ingredients that are to be delivered to the final consumer in which either protein or DNA resulting from genetic modification is present, shall be subject to additional specific labeling requirements. Since 1994, genetically altered tomatoes, squash, potatoes, canola,...article 2002
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Appel, M.J. (author), Kuper, C.F. (author), Woutersen, R.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)A study was performed to provide data on the disposition, accumulation and toxicity of sodium iron EDTA in comparison with iron (II) sulfate in rats on administration via the diet for 31 and 61 days. Clinical signs, body weights, food consumption, food conversion efficiency, hematology, clinical chemistry and pathology of selected organs were...article 2001
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Hooijschuur, E.W.J. (author), Kientz, C.E. (author), Dijksman, J. (author), Brinkman, U.A.T. (author)The potential of microcolumn liquid chromatography (μLC) and capillary electrophoresis (CE) with on-line, flame photometric detection (FPD)in the P-selective mode has been studied for determination of polar P-containing pesticides, glyphosate and its main metabolite, aminomethylphosphonic acid (AMPA), ethephon, fosetyl-aluminium and acephate....article 2001
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Tromp, R.H. (author), van de Velde, F. (author), van Riel, J. (author), Paques, M. (author)Demonstrations are given of the application of confocal scanning light microscopy (CSLM) on mixtures of gelatine with other food biopolymers. The various aspects of phase separation are visualised in two and three dimensional images. Contrast through fluorescence is obtained either by covalent labelling or non-covalent labelling. There is...article 2001
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Ollilainen, V. (author), Finglas, P.M. (author), van den Berg, H. (author), de Froidmont-Görtz, I. (author)In 1989, the Community Bureau of Reference started a research program to improve the quality of vitamin analysis in food. To achieve this task, vitamin methodology was evaluated and tested by interlaboratory studies and the preparation of certified reference materials, which will be used for quality control of vitamin measurements. The main...article 2001
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Centraal Instituut voor Voedingsonderzoek TNO (author), Crews, H. (author), Alink, G. (author), Andersen, R. (author), Braesco, V. (author), Holst, B. (author), Maiani, G. (author), Ovesen, L. (author), Scotter, M. (author), Solfrizzo, M. (author), van den Berg, R. (author), Verhagen, H. (author), Williamson, G. (author)In this review many examples are given of the complexities involved in using some biomarkers in relation to assessing the effects of dietary exposure, when there is frequently a need to determine changes following long-term low level exposure to dietary components. These range from understanding why the biomarker might be valuable and how best...article 2001
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Botterweck, A.A.M. (author), Verhagen, H. (author), Goldbohm, R.A. (author), Kleinjans, J. (author), van den Brandt, P.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and...article 2000
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Simal-Gándara, J. (author), Sarria-Vidal, M. (author), Rijk, M.A.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A liquid chromatographic method with evaporative mass detection (EMD) is described for the determination of paraffins in food contact materials that do not contain polyolefin oligomers, or paraffins migrating from these materials into fatty food simulants or certain simple foods. A normal-phase column operating at maximum column efficiency...article 2000
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Mol, H.G.J. (author), van Dam, R.C.J. (author), Vreeken, R.J. (author), Steijger, O.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A straightforward and efficient method was developed for the determination of intact daminozide in apples and apple leaves. After extraction with methanol and a clean-up step using a graphitized carbon cartridge, the extract was analysed by ion-trap liquid chromatography-tandem mass spectrometry (LC-MS-MS) using atmospheric pressure chemical...article 1999
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Hulshof, K.F.A.M. (author), Erp van - Baart, M.A. (author), Anttolainen, M. (author), Becker, W. (author), Church, S.M. (author), Couet, C. (author), Hermann-Kunz, E. (author), Kesteloot, H. (author), Leth, T. (author), Martins, I. (author), Moreiras, O. (author), Moschandreas, J. (author), Pizzoferrato, L. (author), Rimestad, A.H. (author), Thorgeirsdottir, H. (author), van Amelsvoort, J.M.M. (author), Aro, A. (author), Kafatos, A.G. (author), Lanzmann-Petithory, D. (author), van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To assess the intake of trans fatty acids (TFA) and other fatty acids in 14 Western European countries. Design and subjects: A maximum of 100 foods per country were sampled and centrally analysed. Each country calculated the intake of individual trans and other fatty acids, clusters of fatty acids and total fat in adults and/or the...article 1999
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van der Linde-Sipman, J.S. (author), van den Inch, T.S.G.A.M. (author), van Nes, J.J. (author), Verhagen, H. (author), Kersten, J.G.T.M. (author), Beynen, A.C. (author), Plekkringa, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)In April 1996, an outbreak of toxic polyneuropathy in cats occurred in the Netherlands. All cats had been fed one of two brands of dry cat food from one manufacturer. Chemical analyses of these foods, stomach contents, and liver and kidney of affected cats revealed contamination with the ionophor salinomycin. Epidemiologic and clinical data were...article 1999
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Koppelman, S. (author), Knulst, A.C. (author), Koers, W.J. (author), Penninks, A.H. (author), Peppelman, H. (author), Vlooswijk, R. (author), Pigmans, I. (author), van Duijn, G. (author), Hessing, M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Hazelnuts are widely used in the food industry owing to their nutritive value and taste. The amount of hazelnut present in a recipe is usually considered as a mark of quality. On the other hand, contamination of foods that normally do not contain hazelnuts is a threat for patients with a hazelnut allergy. For this reason, the availability of a...article 1999
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Koppelman, S.J. (author), Wensing, M. (author), de Jong, G.A.H. (author), Knulst, A.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A new process for restructured meat and fish has been introduced to the market recently. Its main compound is casein, and it may therefore endanger patients with a milk allergy. Chemicals/CAS: Anti-Inflammatory Agents; Caseins; Lactoglobulins; Methylprednisolone, 83-43-2article 1999
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Lambe, J. (author), Kearney, J. (author), Becker, W. (author), Hulshof, K. (author), Dunne, A. (author), Gibney, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective: To examine the hypothesis that there is sufficient agreement between percentage of households purchasing selected foods using household budget surveys and percentage of individuals consuming these foods as determined in individual-based surveys to allow the former to act as a surrogate for the latter when estimating food chemical...article 1998
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van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Fatty Acidsarticle 1998
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Brussaard, J.H. (author), van Dokkum, W. (author), van der Paauw, C.G. (author), de Vos, R.H. (author), de Kort, W.L.A.M. (author), Löwik, M.R.H. (author), TNO Voeding (author)To assess the level of exposure to food contaminants (cadmium, lead, PCBs, DDT, hexachlorobenzene, nitrate and malathion) a total-diet study was carried out. A total of 226 food products were analysed individually; the concentration of contaminants in products not selected for analysis was estimated with the help of published data. The results...article 1996
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van den Berg, H. (author), van Schaik, F. (author), Finglas, P.M. (author), de Froidmont-Görtz, I. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)An intercomparison study on the determination of vitamin B-1, B-2 and B-6 was performed as part of the EU MAT project involving 16 laboratories. Each laboratory was requested to analyse three different food samples (lyophilized pig's liver, mixed vegetables and wholemeal flour, respectively) using their 'in-house' method as well as an 'optimal...article 1996
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Baleiras Couto, M.M. (author), Vogels, J.T.W.E. (author), Hofstra, H. (author), Huis in 'tVeld, J.H.J. (author), van der Vossen, J.M.B.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The random amplified polymorphic DNA (RAPD) assay and the restriction enzyme analysis of PCR amplified rDNA are compared for the identification of the common spoilage yeasts Zygosaccharomyces bailii, Z. rouxii, Saccharomyces cerevisiae, Candida valida and C. lipolytica. Both techniques proved to be adequate tools for yeast identification. Since...article 1995