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EM - Based GaN Transistor Small-Signal Model Scaling

van der Bent, G. (author), de Hek, A.P. (author), van Vliet, F.E. (author)

A small-signal model of a Gallium Nitride (GaN) Field Effect Transistor (FET) is created which consists of a compact linear model of the intrinsic gate fingers and an Electro-Magnetic (EM)-based model of the extrinsic part. Accurate scaling of transistor size is obtained which means that larger transistors than supported by standard (foundry)...

conference paper 2018

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Differences in injury risk and characteristics between Dutch amateur and professional soccer players

van Beijsterveldt, A.M.C. (author), Stubbe, J.H. (author), Schmikli, S.L. (author), van de Port, I.G.L. (author), Backx, F.J.G. (author)

Objectives: To compare the incidence and characteristics of injuries between Dutch amateur and professional male soccer players during one entire competition season. Design: A prospective two-cohort design. Methods: During the 2009-2010 season, 456 Dutch male amateur soccer players and 217 professional players were prospectively followed....

article 2015

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An upscaling workflow for recovery evaluation in heavy oil reservoirs

Leeuwenburgh, O. (author), Hofstee, C. (author), Wilschut, F. (author)

The displacement of heavy oil by water flooding is characterized by instable features known as viscous fingers. These fingers may form at very small scales, as can be observed in laboratory experiments and predicted from instability theory. Explicit representation of such features in large-scale reservoir models is practically impossible because...

conference paper 2015

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Functions of the CCCH type zinc finger protein OsGZF1 in regulation of the seed storage protein GluB-1 from rice

Chen, Y. (author), Sun, A. (author), Wang, M. (author), Zhu, Z. (author), Ouwerkerk, P.B.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)

Glutelins are the most abundant storage proteins in rice grain and can make up to 80 % of total protein content. The promoter region of GluB-1, one of the glutelin genes in rice, has been intensively used as a model to understand regulation of seed-storage protein accumulation. In this study, we describe a zinc finger gene of the Cys3His1 (CCCH...

article 2014

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Dynamic adaptation of the peripheral circulation to cold exposure

Cheung, S.S. (author), Daanen, H.A.M. (author)

Humans residing or working in cold environments exhibit a stronger cold-induced vasodilation (CIVD) reaction in the peripheral microvasculature than those living in warm regions of the world, leading to a general assumption that thermal responses to local cold exposure can be systematically improved by natural acclimatization or specific...

article 2012

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Trainability of cold induced vasodilatation in fingers and toes

Daanen, H.A.M. (author), Koedam, J. (author), Cheung, S.S. (author)

Subjects that repeatedly have to expose the extremities to cold may benefit from a high peripheral temperature to maintain dexterity and tissue integrity. Therefore, we investigated if repeated immersions of a hand and a foot in cold water resulted in increased skin temperatures. Nine male and seven female subjects (mean 20.4; SD 2.2 years)...

article 2012

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Translational research in genomics of Alzheimer's disease: A review of current practice and future perspectives

Mihaescu, R. (author), Detmar, S.B. (author), Cornel, M.C. (author), van der Flier, W.M. (author), Heutink, P. (author), Hol, E.M. (author), Rikkert, M.G.M.O. (author), van Duijn, C.M. (author), Janssens, A.C.J.W. (author), TNO Kwaliteit van leven (author)

Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...

article 2010

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Task specificity of finger dexterity tests

Berger, M.A.M. (author), Krul, A. (author), Daanen, H.A.M. (author), TNO Defensie en Veiligheid (author)

Finger dexterity tests are generally used to assess performance decrease due to gloves, cold and pathology. It is generally assumed that the O’Connor and Purdue Pegboard test yield similar results. In this experiment we compared these two tests for dry conditions without gloves, and for dry and wet conditions with two types of Nytril gloves. In...

article 2009

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Differences in fixations between grasping and viewing objects

Brouwer, A.M. (author), Franz, V.H. (author), Gegenfurtner, K.R. (author), TNO Defensie en Veiligheid (author)

Where exactly do people look when they grasp an object? An object is usually contacted at two locations, whereas the gaze can only be at one location at the time. We investigated participants' fixation locations when they grasp objects with the contact positions of both index finger and thumb being visible and compared these to fixation...

article 2009

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Humans use visual and remembered information about object location to plan pointing movements

Brouwer, A.-M. (author), Knill, D.C. (author), TNO Defensie en Veiligheid (author)

We investigated whether humans use a target's remembered location to plan reaching movements to targets according to the relative reliabilities of visual and remembered information. Using their index finger, subjects moved a virtual object from one side of a table to the other, and then went back to a target. In some trials, the target shifted...

article 2009

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Characterization of the Aspergillus niger prtT, a unique regulator of extracellular protease encoding genes

Punt, P.J. (author), Schuren, F.H.J. (author), Lehmbeck, J. (author), Christensen, T. (author), Hjort, C. (author), van den Hondel, C.A.M.J.J. (author), TNO Kwaliteit van Leven (author)

Expression of several Aspergillus niger genes encoding major secreted, but not vacuolar, protease genes including the major acid protease gene pepA, was shown to be affected in the previously isolated A. niger protease mutant, AB1.13 [Mattern, I.E., van Noort, J.M., van den Berg, P., Archer, D.A., Roberts, I.N., Hondel, C.A.M.J.J., 1992....

article 2008

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Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in type 2 diabetes mellitus patients and healthy volunteers

van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)

Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...

article 2007

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Correlations between the Poincaré plot and conventional heart rate variability parameters assessed during paced breathing

Guzik, P. (author), Piskorski, J. (author), Krauze, T. (author), Schneider, R. (author), Wesseling, K.H. (author), Wykrȩtowicz, A. (author), Wysocki, H. (author), TNO Biomedical Instrumentation (author)

Aim: To analyze the correlation of the Poincaré plot descriptors of RR intervals with standard measures of heart rate variability (HRV) and spontaneous baroreflex sensitivity (BRS). A physiological model of changing respiratory rates from 6 to 15 breaths/min provided a wide range of RR intervals for analysis. Material and methods: Beat-to-beat...

article 2007

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Temperature limit values for touching cold surfaces with the fingertip

Geng, Q. (author), Holme, I. (author), den Hartog, E.A. (author), Havenith, G. (author), Jay, O. (author), Malchaires, J. (author), Piette, A. (author), Rintama, H. (author), Rissanen, S. (author), TNO Defensie en Veiligheid (author)

Objectives: At the request of the European Commission and in the framework of the European Machinery Directive, research was performed in five different laboratories to develop specifications for surface temperature limit values for the short-term accidental touching of the fingertip with cold surfaces. Methods: Data were collected in four...

article 2006

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The effects of shoulder load and pinch force on electromyographic activity and blood flow in the forearm during a pinch task

Visser, B. (author), Nielsen, P.K. (author), de Kraker, H. (author), Smits, M. (author), Jensen, B.R. (author), Veeger, D. (author), van Dieën, J.H. (author), TNO Kwaliteit van Leven (author), KvL (author)

The object of the current study was to determine whether static contraction of proximal musculature has an effect on the blood flow more distally in the upper extremity. Static contractions of muscles in the neck shoulder region at three levels (relaxed, shoulders elevated and shoulders elevated loaded with 4.95 kg each) were combined with...

article 2006

document

Resistance index of frostbite as a predictor of cold injury in arctic operations

Daanen, H.A.M. (author), van der Struijs, N.R. (author), TNO Defensie en Veiligheid (author)

Cold-induced vasodilation (CIVD) is mentioned as a mechanism that may prevent the occurrence of local cold injuries. The magnitude of the CIVD reaction differs considerably between subjects and there were some indications that those subjects with a fast CIVD reaction with high amplitude had a reduced risk for cold injuries. The purpose of this...

article 2005

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Functional adaptation through changes in regional biochemical characteristics during maturation of equine superficial digital flexor tendons

Lin, Y.L. (author), Brama, P.A.J. (author), Kiers, G.H. (author), de Groot, J. (author), van Weeren, P.R. (author), TNO Preventie en Gezondheid (author)

Objective - To quantify and compare biochemical characteristics of the extracellular matrix (ECM) of specimens harvested from tensional and compressive regions of the superficial digital flexor tendon (SDFT) of horses in age classes that include neonates to mature horses. Sample population - Tendon specimens were collected on postmortem...

article 2005

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Identifying factors of comfort in using hand tools

Kuijt-Evers, L.F.M. (author), Groenesteijn, L. (author), de Looze, M.P. (author), Vink, P. (author), TNO Arbeid (author)

To design comfortable hand tools, knowledge about comfort/discomfort in using hand tools is required. We investigated which factors determine comfort/discomfort in using hand tools according to users. Therefore, descriptors of comfort/discomfort in using hand tools were collected from literature and interviews. After that, the relatedness of a...

article 2004

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Reconstruction of brachial pressure from finger arterial pressure during orthostasis

TNO Biomedical Instrumentation (author), Bogert, L.W.J. (author), Harms, M.P.M. (author), Pott, F. (author), Secher, N.H. (author), Wesselinge, K.H. (author), van Lieshout, J.J. (author)

Introduction: In patients with recurrent syncope, monitoring of intra-arterial pressure during orthostatic stress testing is recommended because of the potentially sudden and rapid development of hypotension. Replacing brachial arterial pressure (BAP) by the non-invasively obtained finger arterial pressure (FinAP) has advantages because...

article 2004

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Finometer, finger pressure measurements with the possibility to reconstruct brachial pressure

Guelen, I. (author), Westerhof, B.E. (author), van der Sar, G.L. (author), van Montfrans, G.A. (author), Kiemeneij, F. (author), Wesseling, K.H. (author), Bos, W.J.W. (author), Gaubius Instituut TNO (author)

Objective: To evaluate three methods aimed at the reconstruction of brachial pressure from non-invasive finger arterial pressure measurements as implemented in the Finometer™, (FMS, Finapres Measurement Systems, Arnhem, Netherlands), the successor to the Finapres™ (TNO Siomedical Instrumentation, Amsterdam, Netherlands). Methods: Finger arterial...

article 2003