Searched for: subject%3A%22Fibrinolysis%22
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Nagel, A. (author), Meijer, P. (author), Los, P. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)
article 1994
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Kooistra, T. (author), Schrauwen, Y. (author), Arts, J. (author), Emeis, J.J. (author), Gaubius Instituut TNO (author)
The fibrinolytic activity of blood is to a large extent determined by the plasma level of tissue-type plasminogen activator (t-PA). Changes in the plasma level of t-PA are mainly achieved by the endothelium by two mechanisms: (a) a rapid, short-term release of t-PA, which occurs within minutes (acute release, regulated secretion) and (b) a long...
article 1994
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van Hinsbergh, V.W.M. (author), Vermeer, M. (author), Koolwijk, P. (author), Grimbergen, J. (author), Kooistra, T. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
The plasminogen activator inhibitor PAI-1 is markedly elevated in vivo and in vitro upon exposure to the inflammatory mediators tumor necrosis factor α (TNFα), interleukin-1 (IL-1), and bacterial lipopolysaccharide. Here we report that the isoflavone compound genistein prevents the increase in synthesis of PAI-1 induced by these inflammatory...
article 1994
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Bos, R. (author), Revet, M. (author), Nieuwenhuizen, W. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)
This article describes a two-step bio-immuno assay (BIA), which determines active (free) tissue-type plasminogen activator (t-PA) in (acidified) plasma. Plasma samples, diluted in buffer of pH 6.0, are added to the wells of a microtiter plate containing an immobilised monoclonal antibody which binds t-PA without affecting t-PA activity. After an...
article 1994
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Kluft, C. (author), TNO Preventie en Gezondheid (author)
In the population at large and in individual normal volunteers, baseline molar concentratios of t-PA and PAI-1 in plasma show a strong correlation. Evidence is summarized that insulin resistance is a prominent cause of interindividual variation, next to possible contributions of vascular inflammation and steroid hormones. In healthy volunteers,...
article 1994
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van de Kar, N.C.A.J. (author), van Hinsbergh, V.W.M. (author), Brommer, E.J.P. (author), Monnens, L.A.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Fibrinolytic parameters and von Willebrand factor (vWF) antigen were measured in the plasma of 10 patients with hemolytic uremic syndrome (HUS). Samples were taken at presentation and again 2 wk later, before and after infusion of 1-desamino-8-arginine vasopressin. Compared with the plasma values of healthy control children, levels of tissue...
article 1994
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Padró, T. (author), van den Hoogen, C.M. (author), Emeis, J.J. (author), Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
The aim of the present study was to investigate whether hypothyroidism would affect the components of the rat plasma fibrinolytic system. Hypothyroidism was induced by feeding rats a thiouracil-containing diet for 2 weeks. During this period, half of the animals received subcutaneous injections of L-thyroxine (20 μg/kg daily) to restore thyroid...
article 1993
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Otter, M. (author), Gaubius Laboratory, IVVO-TNO, Zernikedreef 9, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Dissertation abstract
article 1993
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Nieuwenhuizen, W. (author), Gaubius Laboratory Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Increased plasma levels of soluble fibrin are considered as molecular markers of an impending thrombotic event. Several methods to assess soluble fibrin have been in existence for many years. Most of those methods are nonspecific, semiquantitative or too laborious to be used in clinical practice. More recent methods are quantitative and...
article 1993
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Gaubius instituut Instituut voor verouderings- en vaatziekten onderzoek TNO (author), de Munk, G.A.W. (author)
doctoral thesis 1993
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Haan, J. (author), Kluft, C. (author), Leebeek, F.W.G. (author), de Bart, A.C.W. (author), Buruma, O.J. (author), Roos, R.A.C. (author)
In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with...
article 1992
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Emeis, J.J. (author), van den Hoogen, C.M. (author), Gaubius Laboratory IVVO-TNO, P.O. Box 430, 2300 AK Leiden, Netherlands Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Pharmacological modulation of the in vivo induction of plasminogen activator inhibitor type-1 (PAI-1) synthesis was studied in rats using the induction of PAI-1 by endotoxin as a model system. Both the cyclooxygenase inhibitors acetylsalicylic acid and indomethacin enhanced PAI-1 induction. The combined cyclooxygenase-lipoxygenase inhibitor,...
article 1992
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Dooijewaard, G. (author), van Boheemen, P.A. (author), Binnema, D.J. (author), Kluft, C. (author), Gaubius Laboratory, VVO-TNO, PO Box 430, 2300 AK Leiden, Instituut voor verouderings- en vaatziekten onderzoek TNO (author)
Chemicals/CAS: Tissue Plasminogen Activator, EC 3.4.21.68; Urinary Plasminogen Activator, EC 3.4.21.73
article 1992
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Emeis, J.J. (author), Gaubius Instituut TNO (author)
Chemicals/CAS: Blood Coagulation Factors; Tissue Plasminogen Activator, EC 3.4.21.68
article 1992
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Bos, R. (author), Nieuwenhuizen, W. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
article 1992
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Kluft, C. (author), Gaubius Instituut TNO (author)
Chemicals/CAS: blood clotting factor 12, 9001-30-3; high molecular weight kininogen, 97792-85-3; plasminogen activator, 9039-53-6; prekallikrein, 9055-02-1; tissue plasminogen activator, 105913-11-9; urokinase, 139639-24-0; Factor XII, 9001-30-3; Kininogens; Prekallikrein, 9055-02-1
article 1992
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Emeis, J.J. (author), Verheijen, J.H. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)
Chemicals/CAS: Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68
article 1992
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Gaubius Instituut TNO (author), Otter, M. (author), Kuiper, J. (author), Berkel T.J.C. van, (author), Rijken, D.C. (author)
Chemicals/CAS: mannose receptor; Mannose, 31103-86-3; PLAT protein, human; Receptors, Cell Surface; Receptors, Immunologic; Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68.
article 1992
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Gaubius Instituut TNO (author), Brommer, E.J.P. (author), van Potter Loon, B.J. (author), Rijken, D.C. (author), van Bockel, J.H. (author)
Chemicals/CAS: Plasminogen, 9001-91-6; Streptokinase, EC 3.4.-.
article 1992
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Gaubius Instituut TNO (author), van Hinsbergh, V.W.M. (author)
Chemicals/CAS: Cytokines; Plasminogen Activator Inhibitor 1; plasminogen activator, urokinase receptors; Plasminogen, 9001-91-6; Receptors, Cell Surface; Urinary Plasminogen Activator, EC 3.4.21.73.
article 1992
Searched for: subject%3A%22Fibrinolysis%22
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