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Olthof, M.R. (author), van Vliet, T. (author), Boelsma, E. (author), Verhoef, P. (author)High plasma homocysteine is a risk for cardiovascular disease and can be lowered through supplementation with 6 g/d of betaine. However, dietary intake of betaine is ∼0.5-2 g/d. Therefore, we investigated whether betaine supplementation in the range of dietary intake lowers plasma homocysteine concentrations in healthy adults. Four groups of 19...article 2003
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Steenge, G.R. (author), Verhoef, P. (author), Katan, M.B. (author)Elevated levels of plasma total homocysteine are associated with a higher risk of cardiovascular disease. Betaine and 5-methyltetrahydrofolate can remethylate homocysteine into methionine via independent reactions. We determined the effect of daily betaine supplementation, compared with both folic acid and placebo, on plasma concentrations of...article 2003
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PG (author), Tchetverikov, I. (author), Verzijl, N. (author), Huizinga, T.W.J. (author), TeKoppele, J.M. (author), Hanemaaijer, R. (author), de Groot, J. (author)Objective. The aim of the present study was to analyze alpha2Macroglobulin/MMP (alpha2M/MMP) complex formation and to investigate whether MMP activity in alpha2M/MMP complexes in serum can be used as a disease marker in rheumatoid arthritis (RA). Methods. High and low molecular weight (H/LMW) substrates and inhibitors and size exclusion were...article 2003
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van Heijningen, M. (author), Badaroglu, M. (author), Donnay, S. (author), Gielen, G.G.E. (author), de Man, H.J. (author)More and more system-on-chip designs require the integration of analog circuits on large digital chips and will therefore suffer from substrate noise coupling. To investigate the impact of substrate noise on analog circuits, information is needed about digital substrate noise generation. In this paper, a recently proposed simulation methodology...article 2002
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Mojet, J. (author), Köster, E.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Memory plays a major role in the formation of food expectations. How accessible and how accurate is incidentally acquired and stored product information? In the present experiment the memory for variations in texture (and flavour) was tested with a new and ecologically valid method. Subjects (N = 69:35 women, 34 men, age 19-59 yrs) came to the...article 2002
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Verhoef, P. (author), Pasman, W.J. (author), van Vliet, T. (author), Urgert, R. (author), Katan, M.B. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Background: A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown. Objective: The objective was to determine whether caffeine explains the...article 2002
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Riese, H. (author), Houtman, I.L.D. (author), Doornen, L.J.P. (author), de Geus, E.J.C. (author)This study examined the possible effects of job demands, decision latitude, and job-related social support on risk indicators for cardiovascular disease (CVD) in 165 female nurses. Job strain was measured with the Job Content Questionnaire; CVD risk was measured with insulin, total cholesterol, triglyceride (TG), high-density lipoprotein...article 2000
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Bierens, L. (author), Deprettere, E. (author), TNO Fysisch en Elektronisch Laboratorium (author)We present an efficient approach for the partitioning of algorithms implementing long convolutions. The dependence graph (DG) of a convolution algorithm is locally sequential globally parallel (LSGP) partitioned into smaller, less complex convolution algorithms. The LSGP partitioned DG is mapped onto a signal flow graph (SFG), in which each...article 1998
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TNO Preventie en Gezondheid (author), Brugman, E. (author), Meulmeester, J.F. (author), van der Spee-Wekke, A. (author), Verloove-Vanhorick, S.P. (author)Background: The objective of this study was to provide national figures on the prevalence of breakfast-skipping and the association with sociodemographic variables in 4-15 year old children. Methods: Data of 4,377 children were collected. A food questionnaire (24 h recall) was completed by the parents or by the older children themselves. Results...article 1998
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Bierens, L.H.J. (author), Deprettere, E.F. (author), TNO Fysisch en Elektronisch Laboratorium (author)We present a schematic design methodology for multirate convolution systems, based on combined algorithmic development and architecture design. It allows us to map the algebraic specification of a long convolution algorithm directly onto efficient fast convolution hardware based on short FFT processor elements or dedicated VLSI processors. The...conference paper 1996
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Sijbrands, E.J.G. (author), Westendorp, R.G.J. (author), Hoffer, M.J.V. (author), Frants, R.R. (author), Meinders, A.E. (author), Souverijn, J.H.M. (author), Leuven, J.A.G. (author), van der Laarse, A. (author), Havekes, L.M. (author), Smelt, A.H.M. (author), Gaubius Instituut TNO (author)Apolipoprotein (ape) E2 and high insulin levels are associated with the severity of hypertriglyceridemia in patients with combined hyperlipidemia. To study how these determinants affect very low-density lipoprotein (VLDL) in combined hyperlipidemic patients, we characterized VLDL particles in 106 unrelated patients with combined hyperlipidemia....article 1996
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Zwartenkot, H.T.J. (author), Boerrigter, M.J.G. (author), Bierens, L.H.J. (author), Smit, J. (author), TNO Fysisch en Elektronisch Laboratorium (author)Usually, long convolutions are computed by programmable DSP boards using long FFTs. Typical operational requirements such as minimum power dissipation, minimum volume and high dynamic range/accuracy, make this solution often inefficient and even unacceptable. In this paper we present a single chip floating point solution for large convolution...conference paper 1996
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Nieuwenhuizen, R. (author), Zijl, W. (author), van Veldhuizen, M. (author), Nederlands Instituut voor Toegepaste Geowetenschappen TNO (author)This paper deals with the analytical description of single-phase flow caused by abstraction wells and governed by Darcy's law. Since we are mainly interested in the velocity field upon which an analysis of transport phenomena can be based, we may assume that the flow is quasi steady. A well may be composed of a number of point sinks, therefore...article 1995
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Dirven, H.A.A.M. (author), Megens, L. (author), Oudshoorn, M.J. (author), Dingemanse, M.A. (author), van Ommen, B. (author), van Bladeren, P.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Development of drug resistance against alkylating cytostatic drugs has been associated with higher intracellular concentrations of glutathione (GSH) and increased expression of glutathione S-transferase (GST) enzymes. Therefore, enhanced detoxification by the glutathione/glutathione S-transferase pathway has been proposed as a major factor in...article 1995
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Bos, K.D. (author), Slump, P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: amino acid, 65072-01-7; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; glutamine, 56-85-9, 6899-04-3; Glutamates; Glutamic Acid, 56-86-0; Glutamine, 56-85-9article 1985
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Broerse, J.J. (author), Battermann, J.J. (author), Radiobiologisch Instituut TNO (author)The renewed application of fast neutrons in clinical radiotherapy has been stimulated by fundamental radiobiological findings. The biological effects of high LET radiation, including fast neutrons, are different from those obtained with X-rays in at least three respects: the oxygen enhancement ratio, the sensitivity of cells at different phases...article 1981
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Nooijen, W.J. (author), Koppert, P.W. (author), Gaubius instituut TNO (author)A specific glucagon antiserum was generated in rabbits using a derivatisation of the methionine residue in glucagon. A sensitive and specific assay for glucagon has been developed. Interference with the assay system by plasma factors was abolished by both extraction of plasma samples and the production of glucagon-free plasma for each individual...article 1981
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Radiobiologisch Instituut TNO (author), Broerse, J.J. (author), Broers Challiss, J.E. (author), Mijnheer, B.J. (author)In connection with clinical applications of fast neutrons, depth dose measurements have been carried out for collimated 15 MeV neutron beams at various source to skin distances, using different phantoms of the upper part of the human body. The distribution of fast, thermal and intermediate neutron dose or kerma and gamma dose over the phantoms...article 1975
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Broerse, J.J. (author), Radiobiologisch Instituut TNO (author)Values of the relative biological effectiveness (RBE) of fast neutrons for effect on normal tissue depend not only on the neutron energy and the dose, but also on the type of tissue irradiated. Values of the RBE of 15 MeV neutrons are reviewed for rapidly proliferating rodent tissue, such as mouse bone marrow, mouse intestine and rat skin...article 1974