- document
-
Gayban, A.J.B. (author), Souza, L.A.C. (author), Cooper, S.G. (author), Regalado, E. (author), Kleemann, R. (author), Earley, Y.F. (author)Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage directly related to diabetes, obesity, and metabolic syndrome. The (pro)renin receptor (PRR) has recently been demonstrated to play a role in glucose and lipid metabolism. Here, we test the hypothesis that the PRR regulates the development of diet-induced hepatic...article 2023
- document
-
Al-Saadi, M. (author), Mathes, M. (author), Käsgen, J. (author), Koffrie, R. (author), Mayrock, M. (author), van Mierlo, J. (author), Berecibar, M. (author)This work presents three demos, which include Electric Buses (EBs) from four various brands with lengths of 12 m and 18 m and an Electric Truck (E-truck) for refuse collection. The technical operation of these EVs were analyzed to implement further operational cost optimization on the demo vehicles. The Electric Vehicles (EVs) were tested...article 2022
- document
-
Yang, H. (author), de Wild, P. (author), Lahive, C.W. (author), Wang, Z. (author), Deuss, P.J. (author), Heeres, H.J. (author)Fast pyrolysis is an efficient technology to convert lignocellulosic biomass to a liquid product. However, the high contents of oxygenated compounds and water hinder the direct utilization of pyrolysis oils. Here, we report an upgrading concept to obtain liquid products with improved product properties and enriched in valuable low molecular...article 2022
- document
-
Atanasov, A.N. (author), Ahmad, W.H.R.A.M. (author), Alink, M.S.O. (author), van Vliet, F.E. (author)We propose a fast and simple method to accurately determine the compressing stage in a two-stage amplifier system based on reverse intermodulation and hot S-parameter measurements. The method uses no specialized hardware and needs little reconfiguration, simplifying the measurements. We demonstrate its validity over a broad range of amplifiers...conference paper 2021
- document
-
van Rossum, W.L. (author), Anitori, L. (author)In this article a novel waveform based on agile (or irregular) pulse intervals is presented as a potential approach to simultaneously resolve both range and Doppler ambiguities using a single burst in radar measurements containing very far away and/or very fast targets. The paper shows that, the combination of irregularly spaced transmitted...conference paper 2020
- document
-
Oosterman, J.E. (author), Wopereis, S. (author), Kalsbeek, A. (author)Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity and T2D is significantly higher in shift workers compared to people working regular hours. An accepted hypothesis is that the increased risk for metabolic health problems arises from aberrantly timed eating behavior, that is, eating out of synchrony...article 2020
- document
-
Abe, N. (author), Kato, S. (author), Tsuchida, T. (author), Sugimoto, K. (author), Saito, R. (author), Verschuren, L. (author), Kleemann, R. (author), Oka, K. (author)Non-alcoholic steatohepatitis (NASH) is a fast-growing liver disease in the Western world. Currently, only a few animal models show both the metabolic and histological features of human NASH. We aimed to explore murine NASH models in a time dependent manner that exhibit metabolic, histological and transcriptomic hallmarks of human NASH. For this...article 2019
- document
- Sprung, D. (author), Sucher, E. (author), Grossmann, P. (author), Kociok, T. (author), van Eijk, A.M.J. (author), Stein, K. (author) conference paper 2019
- document
-
Saathof, R. (author), Crowcombe, W.E. (author), Kuiper, S. (author), van der Valk, N.C.J. (author), Pettazzi, F. (author), de Lange, T.J. (author), Kerkhof, P.J. (author), van Riel, M.C.J.M. (author), de Man, H. (author), Truyens, D.C. (author), Ferrario, I. (author)Optical communications will complement radio frequency (RF) communications in the coming decades to enhance throughput, power efficiency and link security of satellite communication links. To enable optical communications technology for intersatellite links and (bi-directional) ground to satellite links, TNO develops a suite of technologies in...conference paper 2018
- document
-
Rosca, B. (author), Wilkins, S. (author)Battery thermal management is essential to efficienct and safe operation of Li-ion batteries, particularly in challenging applications such as fast charging. This work proposes a thermal management control framework based on MPC. The novelty of this approach resides in the focus on incorporating disturbance prediction into the control decision....conference paper 2018
- document
-
Fiamoncini, J. (author), Yiorkas, A.M. (author), Gedrich, K. (author), Rundle, M. (author), Alsters, S.I. (author), Roeselers, G. (author), van den Broek, T.J. (author), Clavel, T. (author), Lagkouvardos, I. (author), Wopereis, S. (author), Frost, G. (author), van Ommen, B. (author), Blakemore, A.I. (author), Daniel, H. (author)Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the postprandial state. We here describe this response to different dietary challenges and report on key determinants linked to its interindividual variability. Healthy men and women (n = 72, 62 ± 8 yr,...article 2017
- document
-
Kasparek, W. (author), Doelman, N.J. (author), Stober, J. (author), Maraschek, M. (author), Zohm, H. (author), Monaco, F. (author), Eixenberger, H. (author), Klop, W.A. (author), Wagner, D. (author), Schubert, M. (author), Schütz, H. (author), Grünwald, G. (author), Plaum, B. (author), Munk, R. (author), Schlüter, K.H. (author)At the tokamak ASDEX Upgrade, experiments to stabilize neoclassical tearing modes (NTMs) by electron cyclotron (EC) heating and current drive in the O-points of the magnetic islands were performed. For the rst time, injection into the O-points of the revolving islands was performed via a fast directional switch, which toggled the EC power...article 2016
- document
-
Vos, H.J. (author), van Neer, P.L.M.J. (author), Verweij, M.D. (author), de Jong, N. (author), Volker, A.W.F. (author)Three-dimensional (3D) high resolution beamforming is made more difficult by high data rates. This can be overcome by two-step imaging approaches such as the synthetic aperture beamforming technique. In this technique the first step significantly reduces the data rate by line-based delay and sum, whereas the second stage recombines the data to a...conference paper 2015
- document
-
Koster, S. (author), Rennen, M. (author), Leeman, W. (author), Houben, G. (author), Muilwijk, B. (author), van Acker, F. (author), Krul, L. (author)One of the main challenges in food contact materials research is to prove that the presence of non-intentionally added substances (NIAS) is not a safety issue. Migration extracts may contain many unknown substances present at low concentrations. It is difficult and time-consuming to identify all these potential NIAS and concurrently to assess...article 2014
- document
-
Wollenweber, J. (author), Busby, D. (author), Wessel-Berg, D. (author), Nepveu, M. (author), Bossie Codreanu, D. (author), Grimstad, A-A. (author), Sijacic, D. (author), Maurand, N. (author), Lothe, A. (author), Wahl, F. (author), Polak, S. (author), Boot, H. (author), Grøver, A. (author), Wildenborg, T. (author)In this paper an integrated workflow is described for risk assessment within CCS. IFPEN, SINTEF and TNO joined forces to define a comprehensive and transparent risk assessment methodology. The tools developed in these institutes are thereby integrated. The workflow can be applied to proposed carbon storage sites. Starting with a qualitative...article 2013
- document
-
Leeuwenburgh, O. (author), Arts, R. (author)The Ensemble Kalman Filter (EnKF), in combination with travel-time parameterization, provides a robust and flexible method for quantitative multi-model history matching to time-lapse seismic data. A disadvantage of the parameterization in terms of travel-times is that it requires simulation of models beyond the update time. A new distance...conference paper 2012
- document
-
Perelaer, J. (author), Abbel, R.J. (author), Layani, M. (author), Grouchko, M. (author), Magdassi, S. (author), Schubert, U.S. (author)Inkjet printing is a nascent technology that developed during the last decades from only printing text and graphics into an important scientific research tool for R&D, where printers are used as a highly reproducible non-contact patterning tool. In contrast to lithography, inkjet printing is an additive technique that requires only small amounts...conference paper 2011
- document
-
Vincenc Obona, J. (author), Ocelík, V. (author), Skolski, J.Z.P. (author), Mitko, V.S. (author), Römer, G.R.B.E. (author), Huis In't Veld, A.J. (author), de Hosson, J.T.M. (author)This paper concentrates on observations of the surface topography by scanning electron microscopy (SEM) on alloyed and stainless steels samples treated by ultrashort laser pulses with duration of 210 fs and 6.7 ps. Globular-like and jet-like objects were found depending on the various levels of the fluence applied. It is shown that these...article 2011
- document
-
Biel, W. (author), Baross, T. (author), Bourauel, P. (author), Dunai, D. (author), Durkut, M. (author), Erdei, G. (author), Hawkes, N. (author), von Hellermann, M. (author), Hogenbirk, A. (author), Jaspers, R. (author), Kiss, G. (author), Klinkhamer, J.F.F. (author), Koning, J.F. (author), Kotov, V. (author), Krasikov, Y. (author), Krimmer, A. (author), Lischtschenko, O. (author), Litnovsky, A. (author), Marchuk, O. (author), Neubauer, O. (author), Offermanns, G. (author), Panin, A. (author), Patel, K. (author), Pokol, G. (author), Schrader, M. (author), Snijders, B. (author), Szabo, V. (author), van der Valk, N.J.C. (author), Voinchet, R. (author), Wolters, J. (author), Zoletnik, S. (author)The ITER core charge exchange recombination spectroscopy (core CXRS) diagnostic system is designed to provide experimental access to various measurement quantities in the ITER core plasma such as ion densities, temperatures and velocities. The implementation of the approved CXRS diagnostic principle on ITER faces significant challenges: First, a...article 2011
- document
-
Rubio-Aliaga, I. (author), de Roos, B. (author), Duthie, S.J. (author), Crosley, L.K. (author), Mayer, C. (author), Horgan, G. (author), Colquhoun, I.J. (author), Le Gall, G. (author), Huber, F. (author), Kremer, W. (author), Rychlik, M. (author), Wopereis, S. (author), van Ommen, B. (author), Schmidt, G. (author), Heim, C. (author), Bouwman, F.G. (author), Mariman, E.C. (author), Mulholland, F. (author), Johnson, I.T. (author), Polley, A.C. (author), Elliott, R.M. (author), Daniel, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Fasting is one of the simplest metabolic challenges that can be performed in humans. We here report for the first time a comprehensive analysis of the human "fasting metabolome" obtained from analysis of plasma and urine samples in a small cohort of healthy volunteers, using nuclear magnetic resonance (NMR), gas chromatography- and liquid...article 2011