Searched for: subject:"Exposure%5C+modeling"
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Franken, R. (author), Tromp, P. (author), van de Hoef, W. (author), Jadoenathmisier, T. (author)
article 2021
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Franken, R.A. (author), Kasiotis, K.M. (author), Tsakirakis, A.N. (author), Chartzela, I. (author), Anastasiadou, P. (author), Fransman, W. (author), Gerritsen-Ebben, R.M. (author), Spaan, S. (author), Goede, H. (author), Machera, K. (author), Gerritsen-Ebben, R. (author)
For many work situations only insufficient exposure data are available to perform proper risk assessment. Because measuring worker exposure can be time consuming and resource intense, the availability of reliable exposure models is important when performing risk assessments. However, the development and improvement of exposure models are...
article 2020
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McNally, K. (author), Gorce, J.P. (author), Goede, H.A. (author), Schinkel, J. (author), Warren, N. (author)
The dermal Advanced REACH Tool (dART) is a Tier 2 exposure modelling tool currently in development for estimating dermal exposure to the hands (mg min-1) for non-volatile liquid and solids-in-liquid products. The dART builds upon the existing ART framework and describes three mass transport processes [deposition (Dhands), direct emission and...
article 2019
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Savic, N. (author), Gasic, B. (author), Schinkel, J. (author), Vernez, D. (author)
The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance...
article 2018
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Marquart, H. (author), Franken, R. (author), Goede, H. (author), Fransman, W. (author), Schinkel, J. (author)
The ECETOC TRA model (presently version 3.1) is often used to estimate worker inhalation and dermal exposure in regulatory risk assessment. The dermal model in ECETOC TRA has not yet been validated by comparison with independent measured exposure levels. This was the goal of the present study. Measured exposure levels and relevant contextual...
article 2017
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Bekker, C. (author), Fransman, W. (author), Boessen, R. (author), Oerlemans, A. (author), Ottenbros, I.B. (author), Vermeulen, R. (author)
Background: Nano-specific inhalation exposure models could potentially be effective tools to assess and control worker exposure to nano-objects, and their aggregates and agglomerates (NOAA). However, due to the lack of reliable and consistent collected NOAA exposure data, the scientific basis for validation of the existing NOAA exposure models...
article 2017
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von Benda-Beckmann, A.M. (author), Wensveen, P.J. (author), Kvadsheim, P.H. (author), Lam, F.P.A. (author), Miller, P.J.O. (author), Tyack, P.L. (author), Ainslie, M.A. (author)
Ramp-up procedures are used to mitigate the impact of sound on marine mammals. Sound exposure models combined with observations of marine mammals responding to sound can be used to assess the effectiveness of ramp-up procedures. We found that ramp-up procedures before full-level sonar operations can reduce the risk of hearing threshold shifts...
bookPart 2016
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Clausen, P.A. (author), Spaan, S. (author), Brouwer, D.H. (author), Marquart, H. (author), le Feber, M. (author), Engel, R. (author), Geerts, L. (author), Jensen, K.A. (author), Kofoed-Sørensen, V. (author), Hansen, B. (author), de Brouwere, K. (author)
The aim of this work was to identify the key mechanisms governing transport of organic chemical substances from consumer articles to cotton wipes. The results were used to establish a mechanistic model to improve assessment of dermal contact exposure. Four types of PVC flooring, 10 types of textiles and one type of inkjet printed paper were used...
article 2016
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Bekker, C. (author), Voogd, E. (author), Fransman, W. (author), Vermeulen, R. (author)
Background: Control banding can be used as a first-tier assessment to control worker exposure to nano-objects and their aggregates and agglomerates (NOAA). In a second tier, more advanced modelling approaches are needed to produce quantitative exposure estimates. As currently no general quantitative nano-specific exposure models are available,...
article 2016
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Bekker, C. (author), Brouwer, D.H. (author), van Duuren-Stuurman, B. (author), Tuinman, I.L. (author), Tromp, P.C. (author), Fransman, W. (author)
This paper reports a study of the dispersion of manufactured nano-objects (MNOs) through the air, both in time and space, during the use of two commercially available nano-spray products and comparable products without MNOs. The main objective was to identify whether personal exposure can occur at a greater distance than the immediate proximity...
article 2014
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von Benda-Beckmann, A.M. (author), Wensveen, P.J. (author), Kvadsheim, P.H. (author), Lam, F.P.A. (author), Miller, P.J.O. (author), Tyack, P.L. (author), Ainslie, M.A. (author)
Ramp-up (or soft-start) procedures are commonly used to mitigate the impact of sound on marine mammals. Although this procedure is often adopted as a common-sense approach, studies that quantify the effectiveness of ramp-up are currently lacking. The effectiveness of ramp-up is investigated by modelling the sound exposure of animals caused by a...
conference paper 2013
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Gorman Ng, M. (author), Semple, S. (author), Cherrie, J.W. (author), Christopher, Y. (author), Northage, C. (author), Tielemans, E. (author), Veroughstraete, V. (author), van Tongeren, M. (author)
Occupational inadvertent ingestion exposure is ingestion exposure due to contact between the mouth and contaminated hands or objects. Although individuals are typically oblivious to their exposure by this route, it is a potentially significant source of occupational exposure for some substances. Due to the continual flux of saliva through the...
article 2012
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Schneider, T. (author), Brouwer, D.H. (author), Koponen, I.K. (author), Jensen, K.A. (author), Fransman, W. (author), van Duuren-Stuurman, B. (author), van Tongeren, M. (author), Tielemans, E. (author)
As workplace air measurements of manufactured nanoparticles are relatively expensive to conduct, models can be helpful for a first tier assessment of exposure. A conceptual model was developed to give a framework for such models. The basis for the model is an analysis of the fate and underlying mechanisms of nanoparticles emitted by a source...
article 2011
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Marquart, H. (author), Schneider, T. (author), Goede, H. (author), Tischer, M. (author), Schinkel, J. (author), Warren, N. (author), Fransman, W. (author), Spaan, S. (author), van Tongeren, M. (author), Kromhout, H. (author), Tielemans, E. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
There is a large variety of activities in workplaces that can lead to emission of substances. Coding systems based on determinants of emission have so far not been developed. In this paper, a system of Activity Classes and Activity Subclasses is proposed for categorizing activities involving chemical use. Activity Classes share their so-called ...
article 2011
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van Tongeren, M. (author), Fransman, W. (author), Spankie, S. (author), Tischer, M. (author), Brouwer, D. (author), Schinkel, J. (author), Cherrie, J.W. (author), Tielemans, E. (author)
The Advanced REACH Tool (ART) is an exposure assessment tool that combines mechanistically modelled inhalation exposure estimates with available exposure data using a Bayesian approach. The mechanistic model is based on nine independent principal modifying factors (MF). One of these MF is the substance emission potential, which addresses the...
article 2011
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Cherrie, J.W. (author), MacCalman, L. (author), Fransman, W. (author), Tielemans, E. (author), Tischer, M. (author), van Tongeren, M. (author), TNO Kwaliteit van Leven (author)
Objectives: In 1999, Cherrie carried out a series of mathematical simulations to investigate dispersion of pollutants through two indoor zones: the near-field (NF) and the far-field (FF). The results of these simulations were used to derive modifying factors for use in exposure modeling. However, in the original simulations, no account was taken...
article 2011
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Fransman, W. (author), van Tongeren, M. (author), Cherrie, J.W. (author), Tischer, M. (author), Schneider, T. (author), Schinkel, J. (author), Kromhout, H. (author), Warren, N. (author), Goede, H. (author), Tielemans, E. (author)
This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe. The ART mechanistic model is based on a...
article 2011
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Tielemans, E. (author), Warren, N. (author), Fransman, W. (author), van Tongeren, M. (author), McNally, K. (author), Tischer, M. (author), Ritchie, P. (author), Kromhout, H. (author), Schinkel, J. (author), Schneider, T. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
This paper provides an outline of the Advanced REACH Tool (ART) version 1.0 and a discussion of how it could be further developed. ART is a higher tier exposure assessment tool that combines mechanistically modelled inhalation exposure predictions with available exposure data using a Bayesian approach. ART assesses exposure for scenarios across...
article 2011
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Baatjies, R. (author), Meijster, T. (author), Lopata, A. (author), Sander, I. (author), Raulf-Heimsoth, M. (author), Heederik, D. (author), Jeebhay, M. (author), TNO Kwaliteit van Leven (author)
Introduction: Exposure to flour dust has been reported as an important risk factor for allergic respiratory disease among bakery workers. A high prevalence of allergic sensitization and asthma was recently reported in South African supermarket bakeries. The aim of this study was to conduct a detailed exposure assessment of these bakeries so as...
article 2010
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Tielemans, E. (author), Warren, N. (author), Schneider, T. (author), Tischer, M. (author), Ritchie, P. (author), Goede, H. (author), Kromhout, H. (author), van Hemmen, J. (author), Cherrie, J.W. (author), TNO Kwaliteit van Leven (author)
REACH (Registration, Evaluation and Authorization of CHemicals) requires improved exposure models that can be incorporated into screening tools and refined assessment tools. These are referred to as tier 1 and 2 models, respectively. There are a number of candidate in tier 1 models that could be used with REACH. Tier 2 models, producing robust...
article 2007
Searched for: subject:"Exposure%5C+modeling"
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