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de Mooij, B. (author), Fekkes, M (author), Miers, A.C. (author), van den Akker, A.L. (author), Scholte, R.H.J. (author), Overbeek, G. (author)Programs that aim to reduce symptoms of social anxiety in children generally include multiple components, such as exposure and cognitive restructuring. It is unknown if separate components yield positive intervention effects in children or whether a combination of components is required. We investigated the effectiveness of exposure, cognitive...article 2023
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Fransman, W. (author), Otten, W. (author), Marquart, H. (author), Preuhs, K. (author), Willemsen, J. (author), Boumann, H. (author), Gerritsen, R. (author)Objectives: Within the chemical legislation, REACH was implemented in order to improve safe working conditions with hazardous substances. Literature and real-life experiences by those concerned have shown that there are still gaps with a need for improved risk communication. This study elaborated on how information provided by REACH is...article 2023
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- Oude Hengel, K.M. (author), Eekhout, I. (author), van Tongeren, M. (author), Pearce, N. (author) public lecture 2023
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Santonen, T. (author), Mahiout, S. (author), Alvito, P. (author), Apel, P. (author), Bessems, J. (author), Bil, W. (author), Borges, T. (author), Bose-O'Reilly, S. (author), Buekers, J. (author), Canas Portilla, A.I. (author), Calvo, A.C. (author), de Alba González, M. (author), Dominguez-Morueco, N. (author), Lopez, M.E. (author), Falnoga, I. (author), Gerofke, A. (author), Caballero, M.D.C.G. (author), Horvat, M. (author), Huuskonen, P. (author), Kadikis, N. (author), Kolossa-Gehring, M. (author), Lange, R. (author), Louro, H. (author), Martins, C. (author), Meslin, M. (author), Niemann, L. (author), Diaz, S.P. (author), Plichta, V. (author), Porras, S.P. (author), Rousselle, C. (author), Scholten, B. (author), Silva, M.J. (author), Šlejkovec, Z. (author), Tratnik, J.S. (author), Joksic, A.Š. (author), Tarazona, J.V. (author), Uhl, M. (author), van Nieuwenhuyse, A. (author), Viegas, S. (author), Vinggaard, A.M. (author), Woutersen, M. (author), Schoeters, G. (author)One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge...article 2023
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Meima, M.Y. (author), Fransman, W. (author), Ziniel, G. (author), Breindl, G. (author)The Roadmap on Carcinogens aims to create awareness on occupational exposure to carcinogens, and ultimately provide innovative approaches to reduce exposure. One of the challenges of this roadmap (Challenge 4.2) is to get more grip on carcinogens created as a by-product during a work process, so called processgenerated carcinogens (PGCs). As...report 2023
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Meima, M.Y. (author), Fransman, W. (author)The Roadmap on Carcinogens aims to create awareness on occupational exposure to carcinogens, and ultimately provide innovative approaches to reduce exposure. One of the challenges of this roadmap (Challenge 4.3) is to gather results, bring together stakeholders and promote the development of SWPs. The current report aims to summarize the status...report 2023
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Difrancesco, S. (author), van Baardewijk, J.U. (author), Cornelissen, A.S. (author), Varon, C. (author), Hendriks, R.C. (author), Brouwer, A.M. (author)Wearable sensors offer new opportunities for the early detection and identification of toxic chemicals in situations where medical evaluation is not immediately possible. We previously found that continuously recorded physiology in guinea pigs can be used for early detection of exposure to an opioid (fentanyl) or a nerve agent (VX), as well as...article 2023
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Turner, M.C. (author), Johannessen, A. (author), Pronk, A. (author), Huss, A. (author), Garde, A.H. (author), Straumfors, A. (author), Ge, C. (author), Janson, C. (author), Falkstedt, D. (author), Oude Hengel, K.M. (author), Broberg, K. (author), Undem, K. (author), Nordby, K.C. (author), Kjellberg, K. (author), Godderis, L. (author), Kogevinas, M. (author), Goldberg, M. (author), Albin, M. (author), Zins, M. (author), Gustavsson, P. (author), de Cid, R. (author), Rugulies, R. (author), Vermeulen, R. (author), van der Zon, S. (author), Koskinen, S. (author), Krokstad, S. (author), Peters, S. (author), Solovieva, S. (author), van den Heuvel Heuvel, S. (author), Leinonen, T. (author), Bodin, T. (author), Garani-Papadatos, T. (author), Sigsgaard, T. (author), Jääskeläinen, T. (author), Bültmann, U. (author), Schlünssen, V. (author)Introduction The EPHOR project is constructing a mega cohort for pooled analysis of data from multiple European cohort studies of occupation and health. The objective is to provide new evidence of the impact of occupational exposures on the risk of major non-communicable diseases, through systematic and agnostic analyses across the life-course....conference paper 2023
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Peters, S. (author), Undem, K. (author), Oude Hengel, K.M. (author), Schlunssen, V. (author), Selander, V. (author), Solovieva, S. (author), Turner, M. (author), Pronk, A. (author), Mehlum, I.S. (author)Objective Within the framework of the Exposome Project for Health and Occupational Research (EPHOR), we aimed to provide an overview of knowledge gaps in the associations between occupational exposures and their health effects across multiple health outcomes. Methods We conducted a narrative umbrella review of occupational risk factors that can...conference paper 2023
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Eekhout, I. (author), van Tongeren, M. (author), Pearce, N. (author), Oude Hengel, K.M. (author)Objective This study aimed to investigate the effects of occupational exposures on the risk of a positive COVID-19 test, and whether this differed across pandemic waves. Methods Data from 207 034 workers from The Netherlands with test data on COVID-19 from June 2020 until August 2021 were available. Occupational exposure was estimated by using...article 2023
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Ruiter, S. (author), Bard, D. (author), Ben Jeddi, H. (author), Saunders, J. (author), Snawder, J. (author), Warren, N. (author), Gorce, J.P. (author), Cauda, E. (author), Kuijpers, E. (author), Pronk, A. (author)Low-cost particulate matter (PM) sensors provide new methods for monitoring occupational exposure to hazardous substances, such as flour dust. These devices have many possible benefits, but much remains unknown about their performance for different exposure monitoring strategies in the workplace. We explored the performance of PM sensors for...article 2023
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Franken, R. (author), Schinkel, J. (author), Spaan, S. (author)Objectives. The Asbestos Removal Exposure Assessment Tool (AREAT) was previously developed to estimate exposure to respirable asbestos fibres during abatement processes. The current study describes the validation and recalibration of the AREAT model with external data. During model validation, the AREAT model was expanded to be able to estimate...article 2023
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Voogt, M. (author), Zandveld, P. (author), Erbrink, H. (author), van Dinther, D. (author), van den Bulk, P. (author), Kos, G. (author), Blom, M.J. (author), de Jonge, D. (author), Helmink, H. (author), Meydam, J. (author), Visser, J. (author), Middel, J. (author), Hoek, G. (author), van Ratingen, S. (author), Wesseling, J. (author), Janssen, N.A.H. (author)Background and objectives In recent years it has been shown that aircraft emissions are a dominant source of ultrafine particles in the surroundings of airports. However, health effects of long-term (monthly to yearly) exposure to these particles are unknown. As part of an integrated research program into the health risks of ultrafine particles...article 2023
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van der Feltz, S. (author), Schlünssen, V. (author), Basinas, I. (author), Begtrup, L.M. (author), Burdorf, A. (author), Bonde, J.P.E. (author), Flachs, E.M. (author), Peters, S. (author), Pronk, A. (author), Stokholm, Z.A. (author), van Tongeren, M. (author), van Veldhoven, K. (author), Oude Hengel, K.M. (author), Kolstad, H.A. (author)Objectives This study investigates the associations between the Danish version of a job exposure matrix for COVID-19 (COVID-19-JEM) and Danish register-based SARS-CoV-2 infection information across three waves of the pandemic. The COVID-19-JEM consists of four dimensions on transmission: two on mitigation measures, and two on precarious work...article 2023
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Ghassabian, A. (author), van den Dries, M.A. (author), Trasande, L. (author), Lamballais, S. (author), Spaan, S. (author), Martinez-Moral, M.P. (author), Kannan, K. (author), Jaddoe, V.W.V. (author), Engel, S.M. (author), Pronk, A. (author), White, T. (author), Tiemeier, H. (author), Guxens, M. (author)Exposure to phthalates, used as plasticizers and solvents in consumer products, is ubiquitous. Despite growing concerns regarding their neurotoxicity, brain differences associated with gestational exposure to phthalates are understudied. We included 775 mother-child pairs from Generation R, a population-based pediatric neuroimaging study with...article 2023
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Rhodes, S. (author), Beale, S. (author), Wilkinson, J. (author), van Veldhoven, K. (author), Basinas, J. (author), Mueller, W. (author), Oude Hengel, K.M. (author), Burdorf, A. (author), Peters, S. (author), Stokholm, Z.A. (author), Schlünssen, V. (author), Kolstad, H. (author), Pronk, A. (author), Pearce, N. (author), Hayward, A. (author), van Tongeren, M. (author)Objective: This study aimed to assess whether workplace exposures as estimated via a COVID-19 job exposure matrix (JEM) are associated with SARS-CoV-2 in the UK. Methods: Data on 244 470 participants were available from the Office for National Statistics Coronavirus Infection Survey (CIS) and 16 801 participants from the Virus Watch Cohort,...article 2022
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Heus, R. (author), van Berlo, M.P.W. (author), van Berlo, B.M.A. (author), Mol, D. (author), Daanen, H.A.M. (author), Kuklane, K. (author)During the early stage of a fire, a process operator often acts as the first responder and may be exposed to high heat radiation levels. The present limit values of long- (>15 min) and short-term exposure (article 2022
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Scholten, B. (author), Portengen, L. (author), Pronk, A. (author), Stierum, R. (author), Downward, G.S. (author), Vlaanderen, J. (author), Vermeulen, R. (author)Background: Chemical risk assessment can benefit from integrating data across multiple evidence bases, especially in exposure–response curve (ERC) modeling when data across the exposure range are sparse. Methods: We estimated the ERC for benzene and acute myeloid leukemia (AML), by fitting linear and spline-based Bayesian meta-regression models...article 2022
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Oude Hengel, K.M. (author), Burdorf, A. (author), Pronk, A. (author), Schlünssen, V. (author), Stokholm, Z.A. (author), Kolstad, H.A. (author), van Veldhoven, K. (author), Basinas, I. (author), van Tongeren, M. (author), Peters, S. (author)Objective This study aimed to construct a job exposure matrix (JEM) for risk of becoming infected with the SARS-CoV-2 virus in an occupational setting. Methods Experts in occupational epidemiology from three European countries (Denmark, The Netherlands and the United Kingdom) defined the relevant exposure and workplace characteristics with...article 2022
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Traversari, A.A.L. (author), Bezemer, R.A. (author), van Heumen, S.P.M. (author), Kompatscher, K. (author), Hinkema, M.J. (author), Eekhout, I. (author)Social distancing measures to lower the risk of SARS-CoV-2 transmission limit seating capacity in and constrain restaurants’ ability to operate in an economically sustainable way. Experiments have been conducted in a real-size mock-up of a restaurant, using different table setting and configurations of the ventilation system. The study has...article 2022