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Feron, V.J. (author), Kruysse, A. (author), Dreef Van Der Meulen, H.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The sub-acute inhalation toxicity of furfural was studied in Syrian golden hamsters. Four groups of ten males and ten females each were repeatedly exposed to furfural vapour at concentrations of 0, 20, 115 and 552 ppm (0, 77,448 and 2165 mg/m3 air) respectively for 6 hours/day, 5 days/week during a period of 13 weeks. At the highest exposure...article 1979
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Bleichrodt, J.F. (author), Roos-Verheij, W.S.D. (author), Medisch Biologisch Laboratorium TNO (author)As in the induction of r mutants in bacteriophage T4 by ??-rays, the radiation-induced reversion of T4 amber mutants to wild-type was found to depend on the product of the DNA-repair gene x of the phage. Neither the efficiency of induction of r mutants nor the efficiency of reversion of ambers was enhanced by the presence of oxygen during...article 1979
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Slaaf, D.W. (author), Hooisma, J. (author), Meeter, E. (author), Stevens, W.F. (author), Medisch Biologisch Laboratorium TNO (author)Electrophysiological and pharmacological properties of neuromuscular junctions formed in tissue culture between chick ciliary ganglia and chick skeletal muscle cells have been studied. Functional neuromuscular junctions are formed already within 24h. No functional acetylcholine (ACh) esterase is present at these endplates. The neurites conduct...article 1979
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Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppm vinyl chloride monomer (VCM), 7 h/day, 5 days/week, for a period of 52 weeks. After 4, 13, 26 and 52 weeks each time 10 rats/sex/group were killed and subjected to extensive examinations. The present paper deals with growth, mortality, haematology, clinical chemistry and...article 1979
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Benschop, H.P. (author), van den Berg, G.R. (author), van Hooidonk, C. (author), de Jong, L.P.A. (author), Kientz, C.E. (author), Berends, F. (author), Kepner, L.A. (author), Meeter, E. (author), Visser, R.P.L.S. (author), Medisch Biologisch Laboratorium TNO (author)Three new nonquaternary oximes have been evaluated with respect to their antidotal activities against organophosphate poisoning. The oximes 1,2,3-thiadiazole-5-carboxaldoxime (1, pKa = 7.6), 2-methyl-1,3,4-thiadiazole-5-carboxaldoxime (2, pKa = 8.4), and 3-methyl-1,2,4-thiadiazole-5-carboxaldoxime (3, pKa = 7.0) were prepared in yields of 56, 24...article 1979
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Vonk, J.W. (author), Quirijns, J.K. (author), Organisch Chemisch Instituut TNO (author)In two soil types small amounts of ??-hexachlorocyclohexane were formed from ??-hexachlorocyclohexane under submerged conditions, but not under aerobic conditions. In the submerged soils ??-tetrachlorocyclohexene was detected as a major metabolite of ??-hexachlorocyclohexane, whereas aerobic soil incubation yielded ??-pentachlorocyclohexene....article 1979
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Pouwels, P.H. (author), Scholten, H.J. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: tryptophan, 6912-86-3, 73-22-3; Anthranilate Synthase, EC 4.1.3.27; Lactose, 63-42-3; RNA, Bacterial; RNA, Messenger; Tryptophan Synthase, EC 4.2.1.20; Tryptophan, 73-22-3article 1979
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Smoorenburg, G.F. (author), van Heusden, E. (author), Instituut voor Zintuigfysiologie TNO (author)Some preliminary results of a research program on the effects of noise traumata on cochlear functioning are given. Measurements reported here include: the latency of the whole-nerve (compound) action potential (AP), the selectivity of frequency-tuning curves (e.g., the Q10-values) measured for the AP (with a forward-masking technique) and for...article 1979
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Vos, O. (author), Wilschut, I.J.C. (author), Medisch Biologisch Laboratorium TNO (author)Mobilization of CFUs from haemopoietic tissues into circulation was studied after injection of different bacterial lipopolysaccharides (LPS), zymosan, phytohaemagglutinin (PHA), concanavalin A (Con A), trypsin and di-isopropyl-fluorophosphate-inhibited trypsin. All bacterial LPS used gave an increase of CFUs in the peripheral blood at 1 h after...article 1979
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Feron, V.J. (author), Kruysse, A. (author), Immel, H.R. (author), Til, H.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The subacute inhalation toxicity of butenolide was examined in hamsters by repeated exposure of 4 groups of 10 males and 10 females to butenolide vapour at concentrations of 0, 5.4, 25 and 130 ppm respectively (6 h/day, 5 days/week) for a period of 13 weeks. The effects found at 130 ppm included eye irritation, salivation, nasal discharge,...article 1979
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Pouwels, P.H. (author), de Groot, G.P. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: tryptophan, 6912-86-3, 73-22-3; Antibiotics, Aminoglycoside; DNA-Directed RNA Polymerases, EC 2.7.7.6; Heparin, 9005-49-6; Rifampin, 13292-46-1; RNA, Bacterial; Tryptophan, 73-22-3article 1979
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Tulleken, C.A.F. (author), van Dieren, A. (author), Mollevanger, W.J. (author), van Eijck, P. (author), Inst. Med. Phys., TNO, Utrecht, Netherlands (author)In a group of 21 cats, the middle cerebral artery pressure (MCAP) was recorded by means of a catheter introduced into the artery at its origin, just distal to the occlusion. The effects of hypertension, hypercapnia, and hypocapnia were studied. In a group of five cats, both middle cerebral arteries (MCA) were catheterized and the pressure was...article 1978
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Tanger, H.J. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)A method is described whereby open field behaviour of rats can be automatically registered using a TV camera, a video converter, an X-Y recorder and a papertape puncher. Use is made of the scanning properties of the TV camera to obtain the X and Y coordinates of the rat's position and to print this position on an X-Y recorder to obtain the...article 1978
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Feron, V.J. (author), Kruysse, A. (author), Til, H.P. (author), Immel, H.R. (author), Centraal instituut voor voedingsonderzoek TNO (author)The subacute inhalation toxicity of acrolein was examined in 4 groups of 20 hamsters, 12 rats and 4 rabbits each, exposed repeatedly to acrolein vapour at concentrations of 0, 0.4, 1.4 and 4.9 ppm (6 hr/day, 5 days/week) for a 13-week period. The most important effects found at the highest level included mortality in rats, ocular and nasal...article 1978
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Mattern, I.E. (author), Greim, H. (author), Medisch Biologisch Laboratorium TNO (author)Bacterial systems for the screening of chemical substances for mutagenic potential are receiving widespread attention. Now that many laboratories have introduced these test systems and a large number of substances has been tested, discrepancies in the results have become apparent. To discuss this problem, a workshop was organized at Neuherberg ...article 1978
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Hooisma, J. (author), Slaaf, D.W. (author), Meeter, E. (author), Stevens, W.F. (author), Medisch Biologisch Laboratorium TNO (author)The influence of various neural explants on the morphology and the survival of chick muscle fibers was studied. A method was developed to evaluate the condition of the muscle fibers using the following four morphological parameters: cross striation, thickness, number of fibers and absence of vacuoles. Chick as well as mouse spinal cord explants...article 1978
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Stevens, W.F. (author), Slaaf, D.W. (author), Hooisma, J. (author), Magchielse, T. (author), Meeter, E. (author), Medisch Biologisch Laboratorium TNO (author)A less complicated source of neurons suitable for this type of studies is the parasympathetic ciliary ganglion. In the pigeon and in the chick this ganglion is known to contain only two classes of neurons, both of which are cholinoceptive and cholinergic and that innervate the muscle fibres of the choroid plexus of the eye, the sphincter iridis...article 1978
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Widmer, M.B. (author), Balner, H. (author), Primatencentrum TNO (author)The genetic basis for MLC reactivity in rhesus monkeys was further investigated. Cells from an intra-RhLA recombinant monkey were MLC reactive with those of an SD-identical sib and with each of two sets of homozygous typing cells carrying either paternal haplotype. Also, cells from a pair of RhLA- identical sibs reacted in MLC with each other,...article 1978
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Kilbey, B.J. (author), Igali, S. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)A statement of general principles and minimal criteria for the screening of chemicals for potential mutagenicity in man that may be used as guidelines for regulatory agencies and industrial organisations. To make clear the potentialities and current limitations of short-term mutagenicity testing for the prediction of genetic and carcinogenic...article 1978
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Wolthuis, O.L. (author), Kepner, L.A. (author), Medisch Biologisch Laboratorium TNO (author)The bisquarternary mono-oxime HI-6, and to a lesser extent HS-6, caused functional recovery of neuromuscular transmission in vivo and in vitro when given 60 min after soman, i.e. when the soman-cholinesterase (AChE) complex is said to be fully 'aged'. Atropinised rats, with the tracheas intubated, received 4 x LD50 soman i.v. and were kept alive...article 1978