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Mattern, I.E. (author), Cocchiarella, L. (author), van Kralingen, C.G. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)Eleven platinum compounds with nitrogen donor ligands, previously tested for anti-tumour activity were studied for induction of prophage lambda and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic...article 1982
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Tulleken, C.A.F. (author), van Dieren, A. (author), ten Veen, J. (author), Lopes Da Silva, F.H. (author), TNO Workgroup Clin. Neurophysiol., Westeinde Hosp., The Hague, Netherlands Medisch Biologisch Laboratorium TNO (author)The local EEG, the local cerebral blood flow (lCBF), and the flow in the distal stump of the occluded middle cerebral artery were simultaneously recorded in 28 acute experiments in cats. Nembutal anesthesia was used eleven times, and Halothane anaesthesia 17 times. The recordings were made via platinum electrodes: 12 in the ischaemic hemisphere,...article 1982
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Kuper, F. (author), Bloksma, N. (author), Hofhuis, F.M. (author), Bruyntjes, J.P. (author), Willers, J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Histological examination of subcutaneous murine Meth A sarcoma 4 h after administration of endotoxin revealed an overt but superficial vasodilation, which had largely disappeared after 24 h. At this time hemorrhagic necrosis could be observed in that region mainly featured by degenerating tumour cells, diffuse hemorrhage and blood vessels filled...article 1982
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Beems, R.B. (author), Spit, B.J. (author), Koeter, H.B.W.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A variety of gastric lesions can be induced in rats by sodium metabisulfite, including the formation of scattered hyperplastic glands in the fundic mucosa which are exclusively lined by large uniform cells, laden with acidophilic granules. Light and electron microscopy, as enzyme histochemistry, showed that the cells lining these glands are...article 1982
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Instituut voor experimentele gerontologie TNO (author), Praaning-Van Dalen, D.P. (author), Knook, D.L. (author)Chemicals/CAS: Serum Albumin, Bovinearticle 1982
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Centraal Instituut voor Voedingsonderzoek TNO (author), Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author)The 4-h LC50 of acetaldehyde in rats was determined and found to be 13,300 ppm (24.0 g/m3 air). In a 4-week study groups of 10 male and 10 female rats were exposed to 0, 400, 1000, 2200 or 5000 ppm acetaldehyde for 6 h/day, 5 days/week. Treatment-related changes observed at the 5000 ppm level included dyspnoea and excitation during the first 30...article 1982
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Instituut voor experimentele gerontologie TNO (author), Kitani, K. (author), Sato, Y. (author), van Bezooijen, K. (author)The biliary excretion of digitoxin (Dt3) and its metabolites was studied in female BN/Bi rats of different ages ranging from 3 to 30 mth. The disappearance of radioactivity from plasma after an i.v. injection of [3H]Dt3 (0.01 mg/100 g body weight) gradually slowed as rat age advanced. The 2-h biliary recovery of radioactivity (percent of the...article 1982
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Appelman, L.M. (author), Hendriksen, C.F.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The subacute inhalation toxicity of ??-ethylacrolein was examined in rats by repeated exposure of 4 groups of 10 males and 10 females each to ??-ethylacrolein vapour at concentrations of 0, 2.0, 9.8 or 48.4 ppm, respectively, (6 h/day, 5 days/week) for a period of 13 weeks. The effects at 48.4 ppm were found to include growth retardation, focal...article 1981
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Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)The effects of etiracetam, a structural analogue or piracetam, were investigated in rats on Y-maze discrimination acquisition, on open field behavior, on one-trial passive avoidance learning and on shuttlebox acquisition and extinction. The results indicate that this drug significantly enhances acquisition and may improve retention without...article 1981
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Sonneveld, P. (author), van den Engh, G.J. (author), Radiobiologisch Instituut TNO (author)Flow cytometry was used to measure the uptake of adriamycin (AM) and daunomycin (DM) by various cell types of the haemopoietic organs and by acute myeloid leukemia (AML) cells. For this purpose, the spontaneous fluorescence of the drugs upon excitation with laser light at 488 nm was measured. The difference in the uptake of these two drugs...article 1981
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Enger-Valk, B.E. (author), van Rotterdam, J. (author), Pouwels, P.H. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: DNA Restriction Enzymes, EC 3.1.21; DNA, Recombinant; Plasmids; Tryptophan, 73-22-3article 1981
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van der Kogel, A.J. (author), Radiobiologisch Instituut (author)Chemicals/CAS: cytarabine, 147-94-4, 69-74-9; methotrexate, 15475-56-6, 59-05-2, 7413-34-5article 1981
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Stitz, L. (author), Kreeftenberg, J.G. (author), Loggen, H.G. (author), Balner, H. (author), Primatencentrum TNO (author)62 Rhesus monkeys were tested at different times after vaccinia virus infection for virus-specific induction of lymphocyte proliferation in vitro or antibody production in vivo. No association was found between identifiable RhLA-controlled antigens and the strength of the cellular proliferative and/or humoral response. Chemicals/CAS: Antibodies,...article 1981
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Feron, V.J. (author), Hendriksen, C.F.M. (author), Speek, A.J. (author), Til, H.P. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A lifespan oral toxicity of vinyl chloride monomer (VCM) was carried out in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10% VCM solution in soya-bean oil. The VCM doses (actual...article 1981
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Mattern, I.E. (author), van der Zwaan, W. (author), Vink, G.J. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: 4 nitroquinoline 1 oxide, 56-57-5; benzo[a]pyrene, 50-32-8; nitrofural, 59-87-0article 1981
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Kerkenaar, A. (author), Organisch Chemisch Instituut TNO (author)Chemicals/CAS: metalaxyl, 57837-19-1; mithramycin, 18378-89-7article 1981
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Magchielse, T. (author), Medisch Biologisch Laboratorium TNO (author)Chemicals/CAS: tubocurarine chloride, 57-94-3, 57-95-4, 8006-51-7article 1981
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Hagenbeek, A. (author), Martens, A.C.M. (author), Radiobiologisch Instituut TNO (author)The efficacy of extracorporeal irradiation of the blood (ECIB) in combination with cell mobilization by dextran sulfate (DS; MW 17,000) was investigated in a rat model for human acute myelocytic leukemia. Repeated injections with DS (q 3 hr) induced a significant increase in the number of peripheral leukemic cells, i.e., up to 4.5 times the...article 1981
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Spit, B.J. (author), Feron, V.J. (author), Hendriksen, C.F.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The hepatic angiosarcoma studied was from a male Wistar rat having been exposed to vinyl chloride monomer (VCM) by the oral route for 120 weeks. Widened sinusoids lined by large electron-lucent, spindle-shaped tumor cells and membrane-bound nuclear-free structures were seen in the transitional zone between the tumor mass and the adjacent liver...article 1981
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Schellekens, H. (author), Weimar, W. (author), de Reus, A. (author), Bolhuis, R.L.H. (author), Cantell, K. (author), Instituut voor Experimentele Gerontologie TNO (author)Chemicals/CAS: Adjuvants, Immunologic; Antibodies, Viral; Interferons, 9008-11-1article 1981