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- Kooijman, S.A.L.M. (author), Metz, J.A.J. (author), Hoofdgroep Maatschappelijke Technologie TNO Centraal Laboratorium TNO (author) article 1984
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Feron, V.J. (author), Immel, H.R. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)The trachea of Syrian golden hamsters was injured by electrocoagulation. The lesions induced as well as the repair process were studied by light and scanning electron microscopy. The changes observed were considered to create the proper conditions for studying the significance of severe focal damage to the respiratory tract for the formation of...article 1984
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Beems, R.B. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Chemicals/CAS: benzo[a]pyrene, 50-32-8; retinol, 68-26-8, 82445-97-4; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Vitamin A, 11103-57-4article 1984
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Woutersen, R.A. (author), Appelman, L.M. (author), Feron, V.J. (author), van der Heijden, C.A. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Male and female Wistar rats were exposed to acetaldehyde vapour at concentrations of 0, 750, 1500 and 3000/1000 ppm during 6 h/day, 5 days/week for up to 27 months. The present paper deals with the results obtained during the first 15 months of the study, including interim kills after 13, 26 and 52 weeks. Major compound-related lesions occurred...article 1984
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Centraal Instituut voor Voedingsonderzoek TNO (author), Leegwater, D.C. (author), Kuper, C.F. (author)Renal histopathology data, obtained in a 3-month feeding study of the effects of different carbohydrates and polyols in the alloxan diabetic rat, have been subjected to factor analysis. The results indicate a primary and a secondary effect of the diabetic state on the kidney of the rat. The primary effect, the 'diabetic factor', was associated...article 1984
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Centraal Instituut voor Voedingsonderzoek TNO (author), Beems, R.B. (author), van Beek, L. (author)Chemicals/CAS: benzo[a]pyrene, 50-32-8; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Carcinogens; Dietary Fats; Fatty Acids, Unsaturated.article 1984
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- Instituut CIVO-Toxicologie en Voeding TNO (author), Reuzel, P.G.J. (author), Immel, H.R. (author), Spit, B.J. (author), Feron, V.J. (author) article 1984
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Luten, J.B. (author), Riekwel Booy, G. (author), van der Greef, J. (author), de Noever ten - Brauw, M.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Organo-arsenic has been isolated from sole, lemon sole, flounder, dab, crab and shrimps by extraction or ion-exchange in combination with thin-layer chromatography. An alkaline digestion of the samples, followed by a reduction with sodiumborohydride leads to the formation of trimethylarsine. The behaviour of the organo-arsenic compound was very...article 1983
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Bosland, M.C. (author), Prinsen, M.K. (author), Kroes, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Prostatic adenocarcinomas were induced in 5 out of 20 Wistar rats upon a single administration of 50 mg/kg N-nitroso-N-methylurea (NMU). The rats were pretreated with a daily dose of 50 mg/kg cyproterone acetate for 3 weeks followed by 3 daily injections of 100 mg/kg testosterone. All tumours developed in the dorsolateral prostate and were...article 1983
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Bemelmans, J.M.H. (author), den Braber, H.J.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Marinated herring from the Baltic Sea was found to have an offensive odor and taste described as iodine-like and phenolic. Fat isolated from herring was found to contain this taint. The volatiles were isolated from the fat, using a molecular distillation and were subsequently fractionated by gas chromatography. A fraction containing the taint...conference paper 1983
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Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...article 1983
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Bragt, P.C. (author), van Dura, E.A. (author), Medisch Biologisch Laboratorium TNO (author)The kinetics of chromium in the rat after a single intratracheal dose of sodium, zinc or lead 51Cr-chromate have been investigated. Sodium chromate and the less soluble zinc chromate were absorbed into the blood and this resulted in increased excretion of chromium into the urine. The insoluble lead chromate was poorly absorbed from the lungs....article 1983
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Prins Maurits Laboratorium TNO (author), Ligtenstein, D.A. (author), Kossen, S.P. (author)The kinetic profile of the oxime HI-6, a potent cholinesterase reactivator, after iv administration of 0.1325 mmol/kg (50 mg/kg) to rats is described. The blood concentrations measured over a period of 300 min can be described by a two-compartment open model. Excretion occurred only by the kidney. Approximately 60% was excreted in unmetabolized...article 1983
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Instituut voor Zintuigfysiologie TNO (author), van Heusden, E. (author), Smoorenburg, G.F. (author)Acoustically evoked responses of single units in the anteroventral part of the cochlear nucleus (AVCN) in the cat were studied together with compound eighth-nerve action potentials (AP). Halfway through the experiments the cats were exposed for half an hour to pink noise at 105 dB SPL, producing an average threshold shift of 30 dB (maximum 50 dB...article 1983
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Abbondandolo, A. (author), Dogliotti, E. (author), Lohman, P.H.M. (author), Berends, F. (author), Medisch Biologisch Laboratorium TNO (author)Cultured Chinese hamster ovary cells were treated with ethylating agents. DNA lesions giving rise to single-strand breaks (ssb) or alkali-labile sites were measured by centrifugation in alkaline sucrose gradients after lysis in alkali. 4 agents with different tendencies to ethylate preferentially either at N or O atoms were compared, namely N...article 1982
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Feron, V.J. (author), Kruysse, A. (author), Woutersen, R.A. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Syrian golden hamsters were exposed to 0 or 2500-1650 ppm acetaldehyde vapour, 7 hr/day, 5 days/week for a period of 52 weeks. A proportion of the animals was given, simultaneously, either intratracheal instillations of benzo(a)pyrene (BP) or subcutaneous injections of diethylnitrosamine (DENA). All treatments were stopped after 52 weeks. The...article 1982
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Magchielse, T. (author), Meeter, E. (author), Medisch Biologisch Laboratorium TNO (author)In combined cultures of chick muscle cells and ciliary ganglia, the effect of indirect, long-term stimulation on the number of neuromuscular contacts on individual muscle cells was studied. Seven days of phasic stimulation resulted in a marked reduction in the number of neuromuscular contacts, the majority of the muscle cells becoming innervated...article 1982
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Lubbe, F.H. (author), Brocades Zaalberg, O. (author), Medisch Biologisch Laboratorium TNO (author)Helper T cells specific for sheep erythrocytes were generated in lethally irradiated mice. The helper effect exerted by these cells was determined in vitro in spleen cell cultures. Irradiation of the helper cells in vivo or in vitro with 1-9 Gy resulted in a bimodal relation between radiation dose and helper effect when measured either...article 1982
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Willems, M.I. (author), de Schepper, G.G. (author), Wibowo, A.A.E. (author), Immel, H.R. (author), Dietrich, A.J.J. (author), Zielhuis, R.L. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The influence of lead on sperm morphology, sister chromatid exchanges or on micronuclei formation was studied on male rabbits after exposure to doses of 0, 0.25, and 0.50 mg lead acetate/kg body weight subcutaneously injected three times a week during 14 weeks, each on a group of five rabbits. At the end of exposure phase the lead in blood...article 1982
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Appelman, L.M. (author), ten Berge, W.F. (author), Reuzel, P.G.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)The acute inhalation toxicity of ammonia was examined in rats using various exposure concentrations and exposure periods. Groups of male and female rats were exposed to dynamic atmospheres containing different concentrations of ammonia for 10, 20, 40 or 60 min. The aim of the study was to establish the relationship between exposure concentration...article 1982