document

Consumption of vegetables and fruits and risk of subtypes of head-neck cancer in the Netherlands Cohort Study

Maasland, D.H.E. (author), van den Brandt, P.A. (author), Kremer, B. (author), Goldbohm, R.A. (author), Schouten, L.J. (author)

There is limited prospective data on the relationship between consumption of vegetables and fruits and the risk of head-neck cancer (HNC) subtypes [i.e., oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC) and laryngeal cancer (LC)]. Therefore, we investigated these associations within the Netherlands Cohort Study, in which 120,852...

article 2015

document

Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: Results from the Netherlands Cohort Study

Maasland, D.H.E. (author), van den Brandt, P.A. (author), Kremer, S.H.A. (author), Goldbohm, R.A. (author), Schouten, L.J. (author)

Background: Prospective data on alcohol consumption, cigarette smoking and risk of head-neck cancer (HNC) subtypes, i.e. oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), are limited. We investigated these associations within the second largest prospective study on this topic so far, the Netherlands Cohort...

article 2014

document

Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies

Männistö, S. (author), Yaun, S.S. (author), Hunter, D.J. (author), Spiegelman, D. (author), Adami, H.O. (author), Albanes, D. (author), van den Brandt, P.A. (author), Buring, J.E. (author), Cerhan, J.R. (author), Colditz, G.A. (author), Freudenheim, J.L. (author), Fuchs, C.S. (author), Giovannucci, E. (author), Goldbohm, R.A. (author), Harnack, L. (author), Leitzmann, M. (author), McCullough, M.L. (author), Miller, A.B. (author), Rohan, T.E. (author), Schatzkin, A. (author), Virtamo, J. (author), Willett, W.C. (author), Wolk, A. (author), Zhang, S.M. (author), Smith-Warner, S.A. (author), TNO Kwaliteit van Leven (author)

Dietary carotenoids have been hypothesized to protect against epithelial cancers. The authors analyzed the associations between intakes of specific carotenoids (alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein + zeaxanthin, and lycopene) and risk of colorectal cancer using the primary data from 11 cohort studies carried out in North...

article 2007

document

Chondrogenic potential of human adult mesenchymal stem cells is independent of age or osteoarthritis etiology

Scharstuhl, A. (author), Schewe, B. (author), Benz, K. (author), Gaissmaier, C. (author), Bühring, H.J. (author), Stoop, R. (author), TNO Kwaliteit van Leven (author)

Osteoarthritis (OA) is a multifactorial disease strongly correlated with history of joint trauma, joint dysplasia, and advanced age. Mesenchymal stem cells (MSCs) are promising cells for biological cartilage regeneration. Conflicting data have been published concerning the availability of MSCs from the iliac crest, depending on age and overall...

article 2007

document

Nitrate intake does not influence bladder cancer risk: The Netherlands Cohort Study

Zeegers, M.P. (author), Selen, R.F.M. (author), Kleinjans, J.C.S. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

Objectives: N-nitroso compounds, endogenously formed from nitrate-derived nitrite, are suspected to be important bladder carcinogens. However, the association between nitrate exposure from food or drinking water and bladder cancer has not been substantially investigated in epidemiologic studies. Methods: We evaluated the associations between...

article 2006

document

Etiology of atopy in infancy: The KOALA Birth Cohort Study

Kummeling, I. (author), Thijs, C. (author), Penders, J. (author), Snijders, B.E.P. (author), Stelma, F. (author), Reimerink, J. (author), Koopmans, M. (author), Dagnelie, P.C. (author), Huber, M. (author), Jansen, M.C.J.F. (author), de Bie, R. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven TNO Voeding (author)

The aim of the KOALA Birth Cohort Study in the Netherlands is to identify factors that influence the clinical expression of atopic disease with a main focus on lifestyle (e.g., anthroposophy, vaccinations, antibiotics, dietary habits, breastfeeding and breast milk composition, intestinal microflora composition, infections during the first year...

article 2005

document

Consumption of vegetables and fruits and risk of ovarian carcinoma: Results from the Netherlands Cohort Study on Diet and Cancer

Mommers, M. (author), Schouten, L.J. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Kwaliteit van Leven (author)

BACKGROUND. To the authors' knowledge, only a few prospective studies to date have investigated the correlation between vegetable and fruit consumption and the risk of ovarian carcinoma and their results have been inconclusive. METHODS. Vegetable and fruit intake was assessed in relation to ovarian carcinoma, among 62,573 postmenopausal women...

article 2005

document

Alcohol and ovarian cancer risk: Results from the Netherlands Cohort Study

Schouten, L.J. (author), Zeegers, M.P.A. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author), TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO (author)

Objective: To study alcohol consumption in relation to ovarian cancer risk in a prospective cohort study. Methods: The Netherlands Cohort Study on diet and cancer was initiated in 1986. A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 62,573 postmenopausal women. Follow-up for cancer was...

article 2004

document

Automation and the future of driver behavior

Janssen, W.H. (author), Wierda, M. (author), van der Horst, A.R.A. (author)

This paper sets out by identifying five plausible stages in the automation of the road traffic system, ranging from the introduction of part systems that support specific task components (navigation, collision avoidance) to full automation of roads and vehicles. It is then attempted to predict how drivers will respond to each successive stage of...

article 1995

document

Nitric oxide suppresses IFN-γ production in the spleen of mercuric chloride-exposed brown Norway rats

Primatencentrum TNO (author), van der Meide, P.H. (author), de Labie, M.C.D.C. (author), Botman, C.A.D. (author), Aten, J. (author), Weening, J.J. (author)

Recently we have shown that the generation of IFNγ-producing cells (IFN-γ pc) were severely suppressed in cultures of Con A-stimulated splenocytes obtained from HgCl2-exposed BN but not Lewis rats. Since BN rats develop a T(H)2-biased polyclonal autoimmune syndrome upon exposure to HgCl2, whereas Lewis rats exhibit a resistant phenotype,...

article 1995

document

Fibrinolytic shut-down after surgery: Impairment of the balance between tissue-type plasminogen activator and its specific inhibitor

D'Angelo, A. (author), Kluft, C. (author), Verheijen, J.H. (author), Gaubius Instituut TNO (author)

In nine patients with non-malignant diseases undergoing major upper abdominal surgery, the mechanism of the postoperative fibrinolytic shut-down was investigated because of its potential significance for postoperative deep vein thrombosis by employing new and specific methods for assessing and stimulating the fibrinolytic system. The shut-down...

article 1985

document

Respiratory tract tumors in hamsters after severe focal injury to the trachea and intratracheal instillation of benzo[a]pyrene

Reynders, J.B.J. (author), Immel, H.R. (author), Scherrenberg, P.M. (author), Feron, V.J. (author), Beems, R.B. (author), Instituut CIVO-Toxicologie en voeding TNO (author)

Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated...

article 1985

document

Effects of endotoxin-treatment on inflammatory cell infiltrates in murine Meth A sarcoma

Kuper, C.F. (author), Bloksma, N. (author), Bruyntjes, J.P. (author), Hofhuis, F.M. (author), Wolferink, G. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)

The effect of intravenously injected endotoxin on inflammatory cells within solid Meth A tumours was studied and central hyperaemia, necrosis and early collapse were observed macroscopically at 4, 24 and 48 h, respectively. The effects were studied in semithin sections and cytocentrifuge preparations of the tumours. The inflammatory cell...

article 1985

document

Precognitive control: open- and closed-loop steering in a lane-change manoeuvre

Instituut voor Zintuigfysiologie TNO (author), Godthelp, J. (author)

This paper presents two experiments in which steering a lane-change manoeuvre is analysed as a precognitive control task. The suggestion that the dependence on instantaneous visual feedback is low during such a task was tested by analysing steering performance under conditions both with and without visual occlusion. Steering force served as the...

article 1985

document

Evaluation of histological changes in the kidneys of the alloxan diabetic rat by means of factor analysis

Centraal Instituut voor Voedingsonderzoek TNO (author), Leegwater, D.C. (author), Kuper, C.F. (author)

Renal histopathology data, obtained in a 3-month feeding study of the effects of different carbohydrates and polyols in the alloxan diabetic rat, have been subjected to factor analysis. The results indicate a primary and a secondary effect of the diabetic state on the kidney of the rat. The primary effect, the 'diabetic factor', was associated...

article 1984

document

Effects of amounts and type of agar on the number of spontaneous revertants in the Ames test

Centraal Instituut voor Voedingsonderzoek TNO (author), de Raat, W.K. (author), Willems, M.I. (author), de Meijere, F.A. (author)

It has been shown that the spontaneous revertants in the Ames test can depend on the amount and type of bottom agar on the plates. The most clear-cut effect was found with his G46 strains, carrying the ??uvrB mutation, and with the new hisG428 strain, TA102. Evidence of mutagenic impurities in agar has been found. Chemicals/CAS: agar, 9002-18-0;...

article 1984

document

Short-term tests in the framework of carcinogen risk assessment to man

Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)

Short-term tests designed to detect possible carcinogenicity have been extensively refined during the last years. Presently, many more or less simple and convenient systems are available to detect mutations, chromosome effects, DNA damage, and malignant transformation. Although their relevance to carcinogenicity is often reasonably good,...

article 1983

document

Tissue damage and nutritional factors in experimental respiratory tract (co-)carcinogenesis

Reuzel, P.G.J. (author), Feron, V.J. (author), Spit, B.J. (author), Beems, R.B. (author), Kroes, R. (author), Instituut CIVO-Toxicologie en voeding TNO (author)

Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamster or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, food restriction, and...

article 1983

document

Low density lipoprotein metabolism by endothelial cells from human umbilical cord arteries and veins

van Hinsbergh, V.W.M. (author), Havekes, L. (author), Emeis, J.J. (author), van Corven, E. (author), Scheffer, M. (author), Gaubius Instituut TNO (author)

Binding and metabolism of low density lipoprotein (LDL) and acetylated LDL were examined in endothelial cells from human umbilical cord arteries and veins. Both high and low affinity LDL interactions were observed. High affinity LDL binding and catabolism were increased five- to sevenfold after preincubation for 18 hours in LPDS containing...

article 1983

document

Diet, faecal pH and colorectal cancer

Instituut CIVO-Toxicologie en voeding TNO (author), van Dokkum, W. (author), de Boer, B.C.J. (author), van Faassen, A. (author), Pikaar, N.A. (author), Hermus, R.J.J. (author)

We suggest that a lower faecal pH may be correlated with a lower mortality of large-bowel cancer and that faecal pH should always be considered in epidemiological studies on the role of diet in colon carcinogenesis.

article 1983