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Bannink, E.M.N. (author), van Sassen, C. (author), van Buuren, S. (author), de Jong, F.H. (author), Lequin, M. (author), Mulder, P.G.H. (author), de Muinck Keizer-Schrama, S.M.P.F. (author), TNO Kwaliteit van Leven (author)Background: Besides short stature, gonadal dysgenesis leading to a lack of oestrogen is one of the main characteristics of Turner syndrome (TS). In most TS girls, puberty is induced with exogenous oestrogens. Objective: To describe the pubertal development and uterine dimensions achieved by low-dose 17β-oestradiol (17β-E2) orally started at an...article 2009
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Hemelaar, M. (author), van der Mooren, M.J. (author), Rad, M. (author), Kluft, C. (author), Kenemans, P. (author), TNO Kwaliteit van Leven (author)Objective: To review the effects of non-oral administration of postmenopausal hormone therapy (HT) on risk markers for atherosclerotic and venous thromboembolic disease.Non-oral postmenopausal HT appears not to increase venous thromboembolic risk, whereas the effect on coronary heart disease risk is less clear. Design: Systematic review of...article 2008
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Blankvoort, B.M.G. (author), Rodenburg, R.J.T. (author), Murk, A.J. (author), Koeman, J.H. (author), Schilt, R. (author), Aarts, J.M.M.J.G. (author), TNO Kwaliteit van Leven (author)This paper describes the screening of 22 extracts from 18 different aquatic environmental samples for androgenic activity, including indirect and interactive effects on androgen receptor (AR)-mediated signal transduction, using the AR-LUX bioassay. Four samples, originating from an industrial wastewater treatment plant (WTP) or the river Meuse,...article 2005