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- Lubczynska, M.J. (author), Muetzel, R.L. (author), el Marroun, H. (author), Hoek, G. (author), Kooter, I.M. (author), Thomson, E.M. (author), Hillegers, M. (author), Vernooij, M.W. (author), White, T. (author), Tiemeier, H. (author), Guxens, M. (author) article 2021
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van Wezel, A.P. (author), van Lente, H. (author), van de Sandt, J.J.M. (author), Bouwmeester, H. (author), Vandeberg, R.L.J. (author), Sips, A.J.A.M. (author)Governments invest in “key enabling technologies,” such as nanotechnology, to solve societal challenges and boost the economy. At the same time, governmental agencies demand risk reduction to prohibit any often unknown adverse effects, and industrial parties demand smart approaches to reduce uncertainties. Responsible research and innovation ...article 2018
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Datta, A. (author), Banerjee, S. (author), Finley, A.O. (author), Hamm, N.A.S. (author), Schaap, M. (author)Particulate matter (PM) is a class of malicious environmental pollutants known to be detrimental to human health. Regulatory efforts aimed at curbing PM levels in different countries often require high resolution space–time maps that can identify red-flag regions exceeding statutory concentration limits. Continuous spatio-temporal Gaussian...article 2016
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- Koval, I.A. (author), Gamez, P. (author), Reedijk, J. (author), TNO Kwaliteit van Leven (author), KvL (author) bookPart 2010
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Neto, B. (author), Kroeze, C. (author), Hordijk, L. (author), Costa, C. (author), Pulles, M.P.J. (author), TNO Bouw en Ondergrond (author)This study explores a model (MIKADO) to analyse scenarios for the reduction of the environmental impact of an aluminium die casting plant. Our model calculates the potential to reduce emissions, and the costs associated with implementation of reduction options. In an earlier paper [Neto, B., Kroeze, C., Hordijk, L., Costa, C., 2008. Modelling...article 2009
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Links, I. (author), Jagt, K.E.V.D. (author), Christopher, Y. (author), Lurvink, M. (author), Schinkel, J. (author), Tielemans, E. (author), Hemmen, J.J.V. (author), TNO Kwaliteit van Leven (author)Exposure data on biocides are relatively rare in published literature, especially for secondary exposure. This is also the case for antifouling exposure. Therefore, a field study was carried out measuring exposure to antifouling paints. Both primary exposure (rolling and spraying) and secondary exposure (during sand blasting) were studied....article 2007
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Hulskotte, J.H.J. (author), van der Gon, H.A.C.D. (author), Visschedijk, A.J.H. (author), Schaap, M. (author), TNO Bouw en Ondergrond (author)In this article we show that brake wear from road traffic vehicles is an important source of atmospheric (participate) copper concentrations in Europe. Consequently, brake wear also contributes significantly to deposition fluxes of copper to surface waters. We estimated the copper emission due to brake wear to be 2.4 kiloton per year. For...conference paper 2007
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Hendriksen, P.J.M. (author), Freidig, A.P. (author), Jonker, D. (author), Thissen, U. (author), Bogaards, J.J.P. (author), Mumtaz, M.M. (author), Groten, J.P. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat liver and kidney measured by microarray analysis. These compounds were selected based on presumed different modes of action. The chemicals were administered daily for 14 days at the Lowest...article 2007
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Hendriks, A.J. (author), Maas-Diepeveen, J.L.M. (author), Heugens, E.H.W. (author), van Straalen, N.M. (author), TNO Kwaliteit van Leven (author)Most of the thousands of substances and species that are of concern for environmental management will not be investigated empirically at ecologically relevant levels because of financial, practical, and ethical constraints. To allow risk assessment for these less well-known categories, we have developed a mechanistic model with classical...article 2005
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van Wendel de Joode, B. (author), van Hemmen, J.J. (author), Meijster, T. (author), Major, V. (author), London, L. (author), Kromhout, H. (author), TNO Kwaliteit van Leven (author)Valid and reliable semi-quantitative dermal exposure assessment methods for epidemiological research and for occupational hygiene practice, applicable for different chemical agents, are practically nonexistent. The aim of this study was to assess the reliability of a recently developed semi-quantitative dermal exposure assessment method (DREAM)...article 2005
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Vreugdenhil, H.J.I. (author), Emmen, H.H. (author), Mulder, P.G.H. (author), Weisglas-Kuperus, N. (author), TNO Voeding (author)PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort,...article 2004
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Vreugdenhil, H.J.I. (author), Lanting, C.I. (author), Mulder, P.G.H. (author), Boersma, E.R. (author), Weisglas-Kuperus, N. (author), TNO Preventie en Gezondheid (author)Objective: Our purpose was to evaluate whether effects of exposure to environmental levels of PCBs and dioxins on development in the Dutch cohort persist until school age. Study design: In the Dutch PCB/dioxin study, cognitive and motor abilities were assessed with the McCarthy Scales of Children's Abilities in children at school age. During...article 2002
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Franzaring, J. (author), Kempenaar, C. (author), van Eerden, L.J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Chemicals/CAS: Benzofurans; Chlorpropham, 101-21-3; Environmental Pollutants; ethofumesate, 26225-79-6; Herbicides; Mesylatesarticle 2001
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Feron, V.J. (author), Groten, J.P. (author), van Bladeren, P.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A complex chemical mixture is defined as a mixture that consists of tens, hundreds or thousands of chemicals, and of which the composition is qualitatively and quantitatively not fully known. In contrast, a simple mixture consists of a relatively small number of chemicals, say ten or less, and the composition of which is fully known. In the...article 1998
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Pulles, M.P.J. (author), TNO Milieu, Energie en Procesinnovatie (author)The term 'statistics' with reference to environmental science and policymaking might mean different things: the development of statistical methodology, the methodology developed by statisticians to interpret and analyse such data, or the statistical data that are needed to understand environmental pollution and to identify possible policy...bookPart 1998
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Koopman-Esseboom, C. (author), Weisglas-Kuperus, N. (author), de Ridder, M.A.J. (author), van der Paauw, C.G. (author), Tuinstra, L.G.M.T. (author), Sauer, P.J.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Objective. To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. Design. Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposure of breastfed infants was...article 1996
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Centraal Instituut voor Voedingsonderzoek TNO (author), Huisman, M. (author), Koopman-Esseboom, C. (author), Lanting, C.I. (author), van der Paauw, C.G. (author), Tuinstra, L.G.M.T. (author), Fidler, V. (author), Weisglas-Kuperus, N. (author), Sauer, P.J.J. (author), Boersma, E.R. (author), Touwen, B.C.L. (author)The neurological optimality of 418 Dutch children was evaluated at the age of 18 months, in order to determine whether prenatal and breast milk mediated exposure to polychlorinated biphenyls (PCBs) and dioxins affected neurological development. Half of the infants were breast-fed, the other half were formula-fed. PCB concentrations in cord and...article 1995
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Centraal Instituut voor Voedingsonderzoek TNO Instituut voor Landbouwkundig Onderzoek van Biochemische Produkten TNO (author), Huisman, J. (author)Antinutritional factors (ANFs) protect the seed against attacks of moulds, bacteria, insects and birds. The defensive effect of ANFs is apparently related to disturbances in digestive processes in insects and microorganisms. When animals consume seeds containing ANFs, the digestive processes and growth may be disturbed in a similar manner. In...article 1991
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- Kooijman, S.A.L.M. (author), Metz, J.A.J. (author), Hoofdgroep Maatschappelijke Technologie TNO Centraal Laboratorium TNO (author) article 1984