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de Lange, M. (author), de Geus, E.J.C. (author), Kluft, C. (author), Meijer, P. (author), van Doornen, L.J.P. (author), Boomsma, D.I. (author), Snieder, H. (author), TNO Kwaliteit van Leven (author)Differences in genetic influence on death from CHD between males and females have been reported. Haemostatic factors have consistently been associated with risk for coronary heart disease (CHD), but sex differences in genetic architecture have not been studied. This study in middle-aged twins investigates whether there are sex differences in...article 2006
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van der Greef, J. (author), Hankemeier, T. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular...article 2006
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Lenior, D. (author), Janssen, W.H. (author), Neerincx, M.A. (author), Schreibers, K. (author), TNO Defensie en Veiligheid TNO Kwaliteit van Leven (author)The theme Smart Transport can be described as adequate human-system symbiosis to realize effective, efficient and human-friendly transport of goods and information. This paper addresses how to attune automation to human (cognitive) capacities (e.g. to take care of information uncertainty, operator trust and mutual man-machine adaptations). An...article 2006
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de Kraker, H. (author), Hendriksen, I.J.M. (author), Hildebrandt, V.H. (author), de Korte, E.M. (author), van der Maas, E.M.M. (author)Er is nagegaan of een 1 jaar durende lunchwandelcampagne werknemers in sedentaire beroepen kan stimuleren om meer te bewegen. Hierbij is gekeken naar het effect van de campagne op het aantal werknemers dat wandelt tijdens de lunch, de frequentie van het lunchwandelen, het percentage werknemers dat voldoet aan de Nederlandse Norm Gezond Bewegen ...article 2005
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TNO Kwaliteit van Leven (author), Kaput, J. (author), Ordovas, J.M. (author), Ferguson, L. (author), van Ommen, B. (author), Rodriguez, R.L. (author), Allen, L. (author), Ames, B.N. (author), Dawson, K. (author), German, B. (author), Krauss, R. (author), Malyj, W. (author), Archer, M.C. (author), Barnes, S. (author), Bortholomew, A. (author), Birk, R. (author), van Bladeren, P. (author), Bradford, K.J. (author), Brown, K.H. (author), Caetano, R. (author), Castle, D. (author), Chadwick, R. (author), Clarke, S. (author), Clemént, K. (author), Cooney, C.A. (author), Corella, D. (author), da Cruz, I.B.M. (author), Daniel, H. (author), Duster, T. (author), Ebbesson, S.O.E. (author), Elliott, R. (author), Fairweather-Tait, S. (author), Felton, J. (author), Fenech, M. (author), Finley, J.W. (author), Fogg-Johnson, N. (author), Gill-Garrison, R. (author), Gibney, M.J. (author), Gillies, P.J. (author), Gustafsson, J.A. (author), Hartman IV, J.L. (author), He, L. (author), Hwang, J.K. (author), Jais, J.P. (author), Jang, Y. (author), Joost, H. (author), Junien, C. (author), Kanter, M. (author), Kibbe, W.A. (author), Koletzko, B. (author), Korf, B.R. (author), Kornman, K. (author), Krempin, D.W. (author), Langin, D. (author), Lauren, D.R. (author), Lee, J.H. (author), Leveille, G.A. (author), Lin, S.J. (author), Mathers, J. (author), Mayne, M. (author), McNabb, W. (author), Milner, J.A. (author), Morgan, P. (author), Muller, M. (author), Nikolsky, Y. (author), van der Ouderaa, F. (author), Park, T. (author), Pensel, N. (author), Perez-Jimenez, F. (author), Poutanen, K. (author), Roberts, M. (author), Saris, W.H.M. (author), Schuster, G. (author), Shelling, A.N. (author), Simopoulos, A.P. (author), Southon, S. (author), Shyong Tai, E. (author), Towne, B. (author), Trayhurn, P. (author), Uauy, R. (author), Visek, W.J. (author), Warden, C. (author), Weiss, R. (author), Wiencke, J. (author), Winkler, J. (author), Wolff, G.L. (author), Zhao-Wilson, X. (author), Zucker, J.D. (author)Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can...article 2005
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Kerstholt, J.H. (author), Jansen, N.J.M. (author), van Amelsvoort, A.G. (author), Broeders, A.P.A. (author), TNO Technische Menskunde (author)An experiment was conducted to investigate the reliability of voice lineups. More specifically, the experiment was designed to look into the effects of retention interval (an immediate test or after a week), speech duration (30 or 70 s) and acoustic environment (indoors or indoors and outdoors) on speaker identification accuracy. In addition,...article 2004
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van Dommelen, P. (author), de Gunst, M.C.M. (author), van der Vaart, A.W. (author), Boomsma, D.I. (author)Longitudinal height and weight data from 4649 Dutch twin pairs between birth and 2.5 years of age were analyzed. The data were first summarized into parameters of a polynomial of degree 4 by a mixed-effects procedure. Next, the variation and covariation in the parameters of the growth curve (size at one year of age, growth velocity, deceleration...article 2004
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Miedema, H.M.E. (author), Vos, H. (author), Instituut voor Ruimtelijke Organisatie TNO (author)This article integrates findings from the literature and new results regarding noise sensitivity. The new results are based on analyses of 28 combined datasets (N=23 038), and separate analyses of a large aircraft noise study (N=10939). Three topics regarding noise sensitivity are discussed, namely, its relationship with noise exposure, its...article 2003
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Rütten, A. (author), Vuillemin, A. (author), Ooijendijk, W.T.M. (author), Schena, F. (author), Sjöström, M. (author), Stahl, T. (author), Vanden Auweele, Y. (author), Welshman, J. (author), Ziemainz, H. (author), TNO Kwaliteit van Leven (author)Objectives: The main objective of this paper is to describe the approach and specific findings of the European Physical Activity Surveillance System (EUPASS) research project. In particular, the analysis presented aims at testing the reliability, comparability and predictive power of different sets of physical activity (PA) indicators. Design:...article 2003
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Brink, M. (author), de Goeij, A.F.P.M. (author), Weijenberg, M.P. (author), Roemen, G.M.J.M. (author), Lentjes, M.H.F.M. (author), Pachen, M.M.M. (author), Smits, K.M. (author), de Bruïne, A.P. (author), Goldbohm, R.A. (author), van den Brandt, P.A. (author)Activation of K-ras oncogene has been implicated in colorectal carcinogenesis, being mutated in 30-60% of the adenocarcinomas. In this study, 737 incident colorectal cancer (CRC) patients, originating from 120 852 men and women (55-69 years at baseline) participating in the Netherlands Cohort Study (NLCS), were studied in order to evaluate...article 2003
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Arts, J.H.E. (author), Kuper, C.F. (author), TNO Voeding (author)Although a number of test protocols have been developed to predict respiratory allergenic potential, none of these are widely applied or fully accepted. However, given the serious health problems caused by respiratory allergy and the ever-increasing stream of new chemicals into workplaces, early identification of chemical respiratory allergens...article 2003
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- de Kleijn-Vrankrijker, M.W. (author), TNO Preventie en Gezondheid (author) article 2003
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van Marken Lichtenbelt, W. (author), Daanen, H.A.M. (author)Purpose of review Cold response can be insulative (drop in peripheral temperature) or metabolic (increase in energy expenditure). Nonshivering thermogenesis by sympathetic, norepinephrine-induced mitochondrial heat production in brown adipose tissue is a well known component of this metabolic response in infants and several animal species. In...article 2003
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Hildebrandt, V.H. (author), Bongers, P.M. (author), van Dijk, F.J. (author), Kempers, H.C.G. (author), Dul, J. (author)The article describes the Dutch Musculoskeletal Questionnaire (DMQ) for the analysis of musculoskeletal workload and associated potential hazardous working conditions as well as musculoskeletal symptoms in worker populations. Its qualities are explored using a database of 1,575 workers in various occupations who completed the questionnaire. The...article 2001
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Fredriks, A.M. (author), van Buuren, S. (author), Burgmeijer, R.J.F. (author), Meulmeester, J.F. (author), Beuker, R.J. (author), Brugman, E. (author), Roede, M.J. (author), Verloove-Vanhorick, S.P. (author), Wit, J.M. (author)Since 1858, an increase of mean stature has been observed in the Netherlands, reflecting the improving nutritional, hygienic, and health status of the population. In this study, stature, weight, and pubertal development of Dutch youth, derived from four consecutive nationwide cross- sectional growth studies during the past 42 y, are compared to...article 2000
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Bos, J.E. (author), Bles, W. (author), TNO Technische Menskunde (author)In an attempt to predict the amount of motion sickness given any kind of motion stimulus, we describe a model using explicit knowledge of the vestibular system. First, the generally accepted conflict theory is restated in terms of a conflict between a vertical as perceived by the sense organs like the vestibular system, and the subjective...article 1998
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- Burgmeijer, R.J.F. (author), van Wieringen, J.C. (author) bookPart 1998
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- Brouwer, D.H. (author), de Haan, M. (author), Leenheers, L.H. (author), de Vreede, S.A.F. (author), van Hemmen, J.J. (author) article 1997
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Hennis, B.C. (author), Boomsma, D.I. (author), van Boheemen, P.A. (author), Engesser, L. (author), Kievit, P. (author), Dooijewaard, G. (author), Kluft, C. (author), TNO Preventie en Gezondheid (author)A pedigree-based maximum likelihood method developed by Lange et al. (12) was used to study the contribution of a newly defined di-allelic polymorphism in histidine-rich glycoprotein (HRG) to the plasma levels of HRG. In four families (n = 99) and 20 volunteers we found a heritability of 70%, an age effect of 3% and an effect of individual...article 1995
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Heus, R. (author), Daanen, H.A.M. (author), Havenith, G. (author), TNO Technische Menskunde (author)Hands are important instruments in daily life. Without hands man is hardly able to function independently. Proper functioning of the hands is determined by several physiological parameters. These physiological parameters in turn are influenced by environmental factors. In this view of the literature, physiological processes in manual dexterity...article 1995