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Instituut CIVO-Toxicologie en Voeding TNO (author), den Besten, C. (author), van Bladeren, P.J. (author), Duizer, E. (author), Vervoort, J. (author), Rietjens, I.M.C.M. (author)In the present study the oxidative dehalogenation of a para-halogenated phenol was studied using pentafluorophenol and its non-para-halogenated analogue 2,3,5,6-tetrafluorophenol as model compounds. 19F NMR was used to characterize the metabolite patterns. In order to study the primary oxidation products of the microsomal cytochrome P450...article 1993
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Bosma, A. (author), Seifert, W.F. (author), Wilson, J.H.P. (author), Roholl, P.J.M. (author), Brouwer, A. (author), Knook, D.L. (author), Instituut voor Verouderings- en Vaatziekten Onderzoek TNO (author)Rats of two strains (BN/BiRij and WAG/Rij) were fed the ethanol-containing Lieber-De Carli liquid diet supplemented with high amounts of vitamin A for 16 months. In contrast to Lieber and co-workers, who showed liver fibrosis developing within 9 months on the same diet in Sprague-Dawley rats, we were unable to demonstrate a histological and...article 1991
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Rutten, A.A.J.J.L. (author), Bequet-Passelecq, B.G.A.G.G. (author), Koeter, H.B.W.M. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)A new method was developed for rabbit skin organ culture. In a two-compartment model, skin discs were cultured on a Millicell-HA insert unit with a microporous membrane which allows transport of culture medium via the dermis into the epidermis, whereas the epidermal side remains free of direct contact with culture medium. In this relatively...article 1990
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Yang, Z. (author), Geise, H.J. (author), Mehbod, M. (author), Debrue, G. (author), Visser, J.W. (author), Sonneveld, E.J. (author), van 't Dack, L. (author), Gijbels, R. (author), Technisch Physische Dienst TNO - TH (author)Fourteen derivatives of trans,trans-1,4-bis[2-phenylethenyl]benzene were synthesized by Wittig reactions as model compounds of poly(paraphenylene vinylene). Structure, configurational homogeneity and absence of ionic impurities were controlled by mass spectrometry, infrared and neutron activation analysis, respectively. Crystallographic unit...article 1990
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Bosland, M.C. (author), Prinsen, M.K. (author), Dirksen, T.J.M. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Carcinomas of the rat prostate induced by a single injection of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, after sequential treatment with cyproterone acetate and testosterone propionate, were evaluated as potential animal model for prostatic cancer. All ten carcinomas examined were located in the...article 1990
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Verwey, W.B. (author), Instituut voor Zintuigfysiologie TNO (author)A previous field study concerning electronic navigation aids showed the advantage, in terms of navigational errors, of auditory presentation of route guidance instructions as compared to visual instructions (see W. B. Verwey and W. H. Janssen, 1988). In the present work, an experiment that tries to approach the issue of optimal route...conference paper 1989
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Zwart, A. (author), Woutersen, R.A. (author), Wilmer, J.W.G.M. (author), Spit, B.J. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)To study in detail possible effects of low concentrations of formaldehyde on the nasal epithelium, Wistar rats were exposed to 0, 0.3, 1 and 3 ppm formaldehyde vapour for 6 h/day, 5 days/week during 3 days or 13 weeks, using in vivo [3H]thymidine labeling for cell proliferation studies, and light and electron microscopy for detecting...article 1988
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- Centra voor micro-elektronica TNO (author) other 1987
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Technisch Physische Dienst TNO - TH (author), Bruinsma, A.J.A. (author)The development of optical methods for detection of ultrasound is important for the technology of non-contact Non-Destructive Evaluation of materials. Several optical methods are limited in their application by their sensitivity for ambient vibrations or their complexity. In this paper a Fiber Time Delay Interferometer is proposed which can be...conference paper 1987
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Fysisch en Elektronisch Laboratorium TNO (author), de Jong, A.N. (author)This presentation summarizes the infrared activities in the Netherlands during the past 30 years and indicates the directions for future work. The capabilities of infrared technology, being passive and useful for night vision applications were envisaged for a long time in our country. The dependence on the military market however made the...conference paper 1987
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van Graft, M. (author), Spit, B.J. (author), Immel, H.R. (author), Feron, V.J. (author), Instituut CIVO-Toxicologie en voeding TNO (author)In a one-year serial sacrifice study 10 mg glass fibres (length, 95% ?? 20 ??m, 89% ?? 12 ??m, 58% ?? 5 ??m and 25% ?? 2 ??m; diameter, 88% ?? 1.0 ??m, 60% ?? 0.5 ??m and 31% ??0.25 ??m) suspended in 0.2 ml saline solution were administered to Syrian golden hamsters by a single intratracheal instillation to determine the clearance of the glass...article 1986
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Technisch Physische Dienst TNO - TH (author), de Graauw, T. (author), Beintema, D. (author), Luinge, W. (author), Ploeger, G. (author), Wildeman, K. (author), Wijnbergen, J. (author), Drapatz, S. (author), Haser, L. (author), Melzner, F. (author), Stacker, J. (author), van der Hucht, K. (author), Kamperman, T. (author), van Dijkhuizen, C. (author), van Agthoven, H. (author), Visser, H. (author), Smorenburg, C. (author)The Short Wavelength Spectrometer (SWS) being developed for the Infrared Space Observatory (ISO) is described. The instrument is a pair of grating spectrometers, used in low orders, that will provide resolving powers of about 1000 from 3 μm to 45 μm. In combination with Fabry Perot etalons, the resolving power will be as high as 30, 000 over the...conference paper 1986
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Technisch Physische Dienst TNO - TH (author)Verslag van een studiedag over hybriede schakelingen, georganiseerd door het Centrum voor Micro-Elektronica Delft in samenwerking met de Technisch Physische Dienst TNO-TH (TPD) en Holland Elektronika op 12 juni 1985 te Delftconference paper 1985
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- van Woerden, J.A. (author), Technisch Physische Dienst TNO - TH (author) conference paper 1985
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Janssen, P.J.M. (author), Bosland, M.C. (author), van Hees, J.P. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)The effects of feeding inorganic tin on the gastrointestinal tract were examined in rats. Three groups of male weanling Wistar rats were fed a diet to which 0, 250, or 500 ppm Sn2+ had been added as SnCl2. A fourth group was subjected to feed restriction by pair feeding with the 500-ppm group. Comparison of the data from the tin-fed groups with...article 1985
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- van Es, H.R. (author), Heemskerk, H.J.M. (author), Fysisch en Elektronisch Laboratorium TNO (author) conference paper 1985
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- van Zuylen, P. (author), Technisch Physische Dienst TNO - TH (author) article 1985
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Feron, V.J. (author), Immel, H.R. (author), Spit, B.J. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)The trachea of Syrian golden hamsters was injured by electrocoagulation. The lesions induced as well as the repair process were studied by light and scanning electron microscopy. The changes observed were considered to create the proper conditions for studying the significance of severe focal damage to the respiratory tract for the formation of...article 1984
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Beems, R.B. (author), Instituut CIVO-Toxicologie en Voeding TNO (author)Chemicals/CAS: benzo[a]pyrene, 50-32-8; retinol, 68-26-8, 82445-97-4; Benzo(a)pyrene, 50-32-8; Benzopyrenes; Vitamin A, 11103-57-4article 1984
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Beems, R.B. (author), Spit, B.J. (author), Koeter, H.B.W.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A variety of gastric lesions can be induced in rats by sodium metabisulfite, including the formation of scattered hyperplastic glands in the fundic mucosa which are exclusively lined by large uniform cells, laden with acidophilic granules. Light and electron microscopy, as enzyme histochemistry, showed that the cells lining these glands are...article 1982