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Wang, M. (author), Hoekstra, S. (author), van Bergen, S. (author), Lamers, G.E.M. (author), Oppedijk, B.J. (author), van der Heijden, M.W. (author), de Priester, W. (author), Schilperoort, R.A. (author), Centrum voor Plantenfysiologisch Onderzoek (author)Intra-nucleosomal cleavage of DNA into fragments of about 200 bp was demonstrated to occur in developing anthers, in which microspores had developed into the mid-late to late uni-nucleate stage in situ, i.e. at the verge of mitosis. The same was observed, but to a much larger extent, if these anthers were pre-treated by a hyper-osmotic shock....article 1999
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van de Vijver, L.P.L. (author), Weber, C. (author), Kardinaal, A.F.M. (author), Grobbee, D.E. (author), Princen, H.M.G. (author), van Poppel, G. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)Coenzyme Q10 (CoQ10) is an important mitochondrial electron transfer component and has been postulated to function as a powerful antioxidant protecting LDL from oxidative damage. It could thus reduce the risk of cardiovascular disease. Thus far, beneficial effects of supplementation with CoQ10 have been reported. To study the relation between...article 1999
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van Rozendaal, B.A.W.M. (author), van de Lest, C.H.A. (author), van Eijk, M. (author), van Golde, L.M.G. (author), Voorhout, W.F. (author), van Helden, H.P.M. (author), Haagsman, H.P. (author)Collectins are carbohydrate binding proteins that are implicated in innate host defense. The lung collectins, surfactant proteins A and D (SP-A and SP-D), bind a variety of pathogens in vitro and influence phagocytosis by alveolar macrophages. In this report we show that SP-D binds endotoxin (lipopolysaccharide, LPS) in vivo in a rat model of...article 1999
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Lupker, H.A. (author), Jansen, S.T.H. (author), TNO Wegtransportmiddelen (author)The objective of this paper is to present a systematic modelling approach to vehicle handling simulation, validation and optimisation. Moreover, special attention will be paid to the use of mathematical tools for the development of a passenger car with active rear wheel steering for yaw motion control. Several models for the vehicle as well as...conference paper 1999
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Bär, A. (author), Lina, B.A.R. (author), de Groot, D.M.G. (author), de Bie, B. (author), Appel, M.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)D-Tagatose is an incompletely absorbed ketohexose (stereoisomer of D-fructose) which has potential as an energy-reduced alternative sweetener. In an earlier 90-day toxicity study, rats fed diets with 10, 15 and 20% D-tagatose exhibited increased liver weights, but no histopathological alterations. To determine whether there might be any...article 1999
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de Best, J.H. (author), Hunneman, P. (author), Doddema, H.J. (author), Janssen, D.B. (author), Harder, W. (author), TNO Milieu, Energie en Procesinnovatie (author)Carbon tetrachloride (52 μM) was biodegraded for more than 72% in an anaerobic packed-bed reactor without addition of an external electron donor. The chloride mass balance demonstrated that all carbon tetrachloride transformed was completely dechlorinated. Chloroform and dichloromethane were sometimes also found as transformation products, but...article 1999
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Nijenboer, F.J. (author), Otten, M.P.G. (author), TNO Fysisch en Elektronisch Laboratorium (author)The Dutch PHARUS system is a polarimetric active phased array SAR capable of performing advanced SAR modes. Advanced SAR modes that are being investigated are: spotlight SAR, sliding spotlight SAR, stepped frequency SAR and interferometric SAR. The flight experiments and automatic beam steering implementations are carried out in co-operation...conference paper 1999
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Centraal Instituut voor Voedingsonderzoek TNO (author), Pierik, A.J. (author), Roseboom, W. (author), Happe, R.P. (author), Bagley, K.A. (author), Albracht, S.P.J. (author)Infrared-spectroscopic studies on the [NiFe]-hydrogenase of Chromatium vinosum-enriched in 15N or 13C, as well as chemical analyses, show that this enzyme contains three non-exchangeable, intrinsic, diatomic molecules as ligands to the active site, one carbon monoxide molecule and two cyanide groups. The results form an explanation for the three...article 1999
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Stoll, M.P. (author), Court, A.J. (author), Smorenburg, C. (author), Visser, H. (author), Crocco, L. (author), Heilimo, J. (author), Honig, A. (author)FLEX is a scientifically driven space mission to provide demonstration/validation of the instrumentation and technique for measuring the natural fluorescence of vegetation in the Fraunhofer lines. The payload consists of high spectral resolution (0.1-0.3 nm) CCD imaging grating spectrometer with two channels: one in the red (648-664 nm)and one...conference paper 1999
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Fähnle, O.W. (author), van Brug, H. (author), Frankena, H.J. (author), Technisch Physische Dienst TNO - TH (author)We present a new finishing process that is capable of locally shaping and polishing optical surfaces of complex shapes. A fluid jet system is used to guide a premixed slurry at pressures less than 6 bars to the optical surface. We used a slurry comprising water and 10% #800 SiC abrasives (21.8 μm to reduce the surface roughness of a BK7 sample...article 1998
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Sinke, A.J.C. (author), Dury, O. (author), Zobrist, J. (author), TNO Milieu, Energie en Procesinnovatie (author)The development of the redox conditions has been studied in an initially aerobic column filled with quartz sand coated with ferrihydrite and subjected to a fluctuating water table. The purpose of this study was to evaluate the effect of water table fluctuations on the redox dynamics and the fate of selected organic pollutants. The column that...article 1998
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Wilbers, A.T.M. (author), TNO Fysisch en Elektronisch Laboratorium (author)High power microwave (HPM) devices are capable of producing peak power up to 40 GW. The ongoingconference paper 1998
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Jansen, S.T.H. (author), Zegelaar, P.W.A. (author), Pacejka, H.B. (author), TNO Wegtransportmiddelen (author)For efficient analysis it is important to choose the proper model that fits the problem that needs to be solved. This paper discusses three pragmatic simulation models for longitudinal behaviour of a passenger car tyre (steady State, Transient and Rigid Ring) that may be used in e.g. an ABS simulation. The characteristics of the simulation...conference paper 1998
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Bast, A. (author), Haenen, G.R.M.M. (author), van den Berg, R. (author), van den Berg, H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Surprisingly, neither the precise pharmacological effect nor the toxicological profile is usually established for food components. Carotenoids are no exception in this regard. Only limited insight into the pharmacology and toxicology of carotenoids exists. It is known that the antioxidant action of carotenoids is determined by 1. electron...article 1998
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Bessems, J.G.M. (author), de Groot, M.J. (author), Baede, E.J. (author), te Koppele, J.M. (author), Vermeulen, N.P.E. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)1. The formation of free radicals during enzyme catalysed oxidation of eight 3,5-disubstituted analogues of paracetamol (PAR) has been studied. A simple peroxidase system as well as cytochrome P450-containing systems were used. Radicals were detected by electron spin resonance (ESR) on incubation of PAR and 3,5-diCH3-, 3,5-diC2H5-, 3,5-ditC4H9-,...article 1998
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Konttinen, Y.T. (author), Halinen, S. (author), Hanemaaijer, R. (author), Sorsa, T. (author), Hietanen, J. (author), Ceponis, A. (author), Xu, J.W. (author), Manthorpe, R. (author), Whittington, J. (author), Larsson, Å. (author), Salo, T. (author), Kjeldsen, L. (author), Stenman, U.-H. (author), Eisen, A.Z. (author), Gaubius Instituut TNO (author)Type IV collagenases/gelatinases (matrix metalloproteinases MMP-2 and MMP-9) in labial salivary glands (LSG) and saliva in Sjogren's syndrome (SS) and healthy controls were studied. Zymograms and Western blots disclosed that SS saliva contained 92/82 kD MMP-9/type IV collagenase duplex. Specific activity measurement disclosed 53.1 ± 9.8 U/mg...article 1998
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Mourad, S. (author), van de Weijer, C.J.T. (author), TNO Wegtransportmiddelen (author)The use of a dedicated auxiliary power unit is essential to utilize the potential that hybrid vehicles offer for efficient and ultra-clean transportation. An example of a hybrid project at the TNO Road-Vehicles Research Institute shows the development and the results of a dedicated auxiliary power unit for a series hybrid powertrain. This...conference paper 1998
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- TNO Technische Menskunde (author), Boer, E.R. (author), Hoedemaeker, D.M. (author) conference paper 1998
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Tsimperidis, I. (author), Gregorkiewicz, T. (author), Bekman, H.H.P.T. (author), Langerak, C.J.G.M. (author), Ammerlaan, C.A.J. (author), TNO Fysisch en Elektronisch Laboratorium (author)The influence of intense infrared (IR) radiation in the range 7-17 μm on the photoluminescence (PL) of erbium in silicon has been investigated. To excite the PL a pulsed Nd:YAG laser operating in the visible with a wavelength of 532 nm has been used. The infrared beam was generated by a free-electron laser. In the experiment the intensity and...article 1997
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Beckers, A.L.D. (author), de Bruijn, W.C. (author), Cleton-Soeteman, M.I. (author), van Eijk, H.G. (author), Gelsema, E.S. (author), TNO Fysisch en Elektronisch Laboratorium (author)Reliable iron concentration data can be obtained by quantitative analyses of image sequences, acquired by electron spectroscopic imaging. A number of requirements are formulated for the successful application of this recently developed in situ quantitative type of analysis. A demonstration of the procedures is given. By application of the...article 1997