Short development milestone risk assessment tool to identify Duchenne Muscular Dystrophy

AIMS: An important goal of monitoring developmental milestones is the early identification of a wide range of disorders that affect child development. Duchenne muscular dystrophy (DMD) is generally detected late and therefore treated late, but previous research showed that more DMD boys fail to attain certain milestones than the general...

Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data

BACKGROUND: Previous cost-effectiveness studies using data from the literature showed that newborn screening for cystic fibrosis (NBSCF) is a good economic option with positive health effects and longer survival. METHODS: We used primary data to compare cost-effectiveness of four screening strategies for NBSCF, i.e. immunoreactive trypsinogen...

A simple calculation of the target height

Translational research in genomics of Alzheimer's disease: A review of current practice and future perspectives

Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AβPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the...

Mental health problems in children with intellectual disability: Use of the Strengths and Difficulties Questionnaire

Background: The assessment of mental health problems in children with intellectual disability (ID) mostly occurs by filling out long questionnaires that are not always validated for children without ID. The aim of this study is to assess the differences in mental health problems between children with ID and without ID, using a short...

Sensitivity of 1H NMR analysis of rat urine in relation to toxicometabonomics. Part I: Dose-dependent toxic fffects of Bromobenzene and paracetamol

1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were administered at five single oral dosages between 2 and 500 mg/kg and between 6 and 1800 mg/kg,...

Referral patterns between the child health care, general practitioners and secondary health care: A prospective descriptive study in the Netherlands

Background: In the Netherlands, preventive child health service (CHS) screening plays an important role in the early detection of congenital, developmental, physical, and mental disorders. Objective: To obtain insight into the referral patterns of children from CHS to general practitioners and from general practitioners to medical specialists....

Uniform procedure of 1H NMR analysis of rat urine and toxicometabonomics Part II: Comparison of NMR profiles classification of hepatotoxicity

A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are...

Referral patterns of children with poor growth in primary health care

Background. To promote early diagnosis and treatment of short stature, consensus meetings were held in the mid nineteen nineties in the Netherlands and the UK. This resulted in guidelines for referral. In this study we evaluate the referral pattern of short stature in primary health care using these guidelines, comparing it with cut-off values...

No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-Leiden/human C-reactive protein transgenic mice

Objective - C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development of atherosclerosis. Mouse CRP is not expressed at high levels under normal conditions and increases in concentration only several-fold during an acute phase response. Because the...

Psychosociale problemen bij peuters: Onderkenning en ingesteld beleid door artsen en verpleegkundigen in de jeugdgezondheidszorg [Psychosocial problems in pre-school children: Recognition and strategy applied by doctors and nurses in child health care]

Objective. To assess the degree to which preventive child health professionals (CHPs) identify and manage psychosocial problems among pre-school children in the general population, and to determine its association with parent-reported behavioral and emotional problems, sociodemographic factors and (mental) health history of children. Design....

De standaard 'opsporing visuele stoornissen 0-19 jaar' van de jeugdgezondheidszorg [The guideline 'Detection of visual disorders at the age of 0-19' from the Dutch association of child health care]

The child health-care guideline 'Detection of visual disorders at the age of 0-19' draws attention to the importance of early detection of visual disorders and provides guidelines to child health-care workers for detecting disorders during routine check-ups. Children under the age of 3 are examined by the 'Early detection of visual disorders'...

Jeugdgezondheidszorg: Veel preventie voor weinig geld [Youth healthcare: Much prevention for little money]

As part of government policy, the 'Youth healthcare' prevention programme is offered free of charge to all children aged 0 to 19 years who are resident in the Netherlands. It consists of a programme of primary prevention (including vaccinations, information and advice) and secondary prevention (screening, surveillance, early diagnosis) and...

Early detection of psychosocial problems in adolescents: How useful is the Dutch Short Indicative Questionnaire (KIVPA)?

Background: Psychosocial problems, such as behavioural, emotional, and educational problems, are highly prevalent among children and adolescents. Early treatment may reduce these problems, if accurately identified. Validated questionnaires may support identification. The aim of this study is to assess the psychometric qualities of such a...

Insulineresistentie en diabetes mellitus type 2 bij kinderen met overgewicht [Insulin resistance and diabetes type 2 in overweight children]

The prevalence of overweight and obesity in children is increasing significantly. This increase is attended by an increase in diabetes type 2 in children and adolescents. The most important risk factor for the rise of insulin resistance amongst young people is overweight. The diagnostic criteria for diabetes mellitus in young people are: (a)...

Development and validation of the observation list for early signs of dementia (OLD)

Objective: Development and validation of a short Observation List of possible early signs of Dementia (OLD) for use in general practice. Design: Stepwise development using reviews of publications and expert consensus. Field study for evaluation of reliability. Validation study (interviews, family forms) using existing valid and reliable measures...