Searched for: subject:"ELSS%5C%2B%5C-%5C%2BEarth%2C%5C%2BLife%5C%2Band%5C%2BSocial%5C%2BSciences"
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Pouwer, M.G. (author)
The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism....
doctoral thesis 2020
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Kozijn, A.E. (author)
This thesis aimed to investigate how metabolic overload contributes to the pathophysiology of knee OA. We explored the role of these independent yet intertwined processes using state-of-the-art lipidomic and cellular approaches in mouse models of diet-induced OA. Chapter 2 presents an overview of twelve preclinical studies in which mice received...
doctoral thesis 2020
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Mulder, P.C.A. (author)
Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common cause of chronic liver disease, and its worldwide prevalence continues to increase in parallel of the obesity epidemic. NAFLD comprises a wide spectrum of liver damage ranging fat accumulation (steatosis) to steatosis with inflammation (non-alcoholic steatohepatitis,...
doctoral thesis 2017
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Morrison, M.C. (author)
Over the past few decades it has become increasingly clear that inflammation – a normal and essential defense mechanism that protects the body from infection and injury – can also be triggered by nutrients and dietary surplus, an inflammatory state that is referred to as metabolic inflammation. This chronic low-grade inflammatory state is...
doctoral thesis 2016
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Liang, W. (author)
Overload of nutrients can lead to diet-induced inflammation, also called metabolic inflammation, which is thought to play an important role in many metabolic diseases, including the development of nonalcoholic fatty liver disease (NAFLD). NAFLD encompasses a spectrum of pathologies that range from simple hepatic steatosis to nonalcoholic...
doctoral thesis 2015
Searched for: subject:"ELSS%5C%2B%5C-%5C%2BEarth%2C%5C%2BLife%5C%2Band%5C%2BSocial%5C%2BSciences"
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