Searched for: subject%3A%22EELS%255C%2B%255C-%255C%2BEarth%252C%255C%2BEnvironmental%255C%2Band%255C%2BLife%22
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Erpelinck, E. (author), Meijers, T. (author), Ariga, K. (author)The TNO InTESTine™ system is developed to study the absorption and translocation of pharmaceutical, biological and nutritional compounds across the intestinal wall in a physiologically relevant model. In this medium-throughput system, fresh ex vivo intestinal tissue from human or animal origin is mounted into a two compartment model with an...other 2019
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Remington, B. (author), Broekman, H.C.H. (author), Blom, W.M. (author), Capt, A. (author), Crevel, R.W.R. (author), Dimitrov, I. (author), Faeste, C.K. (author), Fernandez-Canton, R. (author), Giavi, S. (author), Houben, G.F. (author), Glenn, K.C. (author), Madsen, C.B. (author), Kruizinga, A.K. (author), Constable, A. (author)The development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or...article 2018
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Schaudien, D. (author), Harleman, J.H. (author), Bouallala, F. (author), Kuper, C.F. (author)Toxicologic pathology plays a crucial role in the identification and interpretation of substance-induced health effects. Histology of lymphoid organs is quite sensitive, although it does not flag every model immunotoxic substance. Subtle interferences of toxic compounds, like transmembrane signaling and cell activation, are often not detectable...bookPart 2018
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Ross, A.B. (author), van der Kamp, J.W. (author), King, R. (author), Lê, K.A. (author), Mejborn, H. (author), Seal, C.J. (author), Thielecke, F. (author)Whole grains are a key component of a healthy diet, and enabling consumers to easily choose foods with a high whole-grain content is an important step for better prevention of chronic disease. Several definitions exist for whole-grain foods, yet these do not account for the diversity of food products that contain cereals. With the goal of...article 2017
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Hoeke, G. (author), Wang, Y. (author), van Dam, A.D. (author), Mol, M. (author), Gart, E. (author), Klop, H.G. (author), van den Berg, S.M. (author), Pieterman, E.H. (author), Princen, H.M.G. (author), Groen, A.K. (author), Rensen, P.C.N. (author), Berbée, J.F.P. (author), Boon, M.R. (author)Background and aims Activation of brown adipose tissue (BAT) reduces both hyperlipidemia and atherosclerosis by increasing the uptake of triglyceride-derived fatty acids by BAT, accompanied by formation and clearance of lipoprotein remnants. We tested the hypothesis that the hepatic uptake of lipoprotein remnants generated by BAT activation...article 2017
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He, M. (author), van Wijk, E. (author), van Wietmarschen, H. (author), Wang, M. (author), Sun, M. (author), Koval, S. (author), van Wijk, R. (author), Hankemeier, T. (author), van der Greef, J. (author)The increasing prevalence of rheumatoid arthritis has driven the development of new approaches and technologies for investigating the pathophysiology of this devastating, chronic disease. From the perspective of systems biology, combining comprehensive personal data such as metabolomics profiling with ultra-weak photon emission (UPE) data may...article 2017
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Bezem, J. (author), van der Ploeg, C. (author), Numans, M. (author), Buitendijk, S. (author), Kocken, P. (author), van der Akker, E. (author)Background. Triage in Preventive Child Health Care (PCH) assessments could further the efficient use of human resources and budgets and therefore make extra care possible for children with specific needs. We assessed the costs of routine PCH assessments with and without triage for children aged 5/6 years and 10/11 years. In a triage approach,...article 2017
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Bezem, J. (author)We studied a novel triage approach to the organisation of routine assessments by Preventive Child Health care (PCH), including task-shifting among professionals. In the triage approach, access to PCH, and the detection of the health problems studied, were comparable with the usual approach. The efficient deployment of PCH professionals using...doctoral thesis 2017
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Bezem, J. (author), Kocken, P. (author), Kamphuis, M. (author), Theunissen, M.H.C. (author), Buitendijk, S.E. (author), Numans, M.E. (author)Objectives A novel triage approach to routine assessments was introduced to improve the efficiency of Preventive Child Healthcare (PCH): PCH assistants carried out pre-assessments of all children and sent the children with suspected health problems to follow-up assessments conducted by a physician or nurse. This two-step approach differed from...article 2017
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Bezem, J. (author), Heinen, D. (author), Reis, R. (author), Buitendijk, S.E. (author), Numans, M.E. (author), Kocken, P.L. (author)Background The organisation of health assessments by preventive health services focusing on children’s health and educational performance needs to be improved due to evolving health priorities such as mental health problems, reduced budgets and shortages of physicians and nurses. We studied the impact on the school professionals’ perception of...article 2017
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Bothe, M.K. (author), Maathuis, A.J.H. (author), Bellmann, S. (author), van der Vossen, J.M.B.M. (author), Berressem, D. (author), Koehler, A. (author), Schwejda-Guettes, S. (author), Gaigg, B. (author), Kuchinka-Koch, A. (author), Stover, J.F. (author)Lactulose, a disaccharide of galactose and fructose, used as a laxative or ammonia-lowering drug and as a functional food ingredient, enhances growth of Bifidobacterium and Lactobacillus at clinically relevant dosages. The prebiotic effect of subclinical dosages of Lactulose, however, remains to be elucidated. This study analyses changes in the...article 2017
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van der Zee, S.C. (author), van der Kleij, R. (author), van Rest, J.H.C. (author), Bouma, H. (author)Leugendetectie is een multidisciplinair onderzoeksveld dat zich op dit moment snel ontwikkelt dankzij technologische ontwikkelingen en interesse uit verschillende vakgebieden zoals informatica en behavioral economics. Door leugenonderzoekers wordt onder liegen verstaan het bewust creëren van een verkeerd beeld bij een ander, zonder waarschuwing...article 2016
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Erpelinck, E. (author)TNO’s intestinal screening model (TNO i-screen) helps to quickly identify pharmacological compounds that are metabolized by intestinal microbiota. For pharmaceutical companies, searching for novel pharmaceuticals is a complex and time-consuming process. When a novel drug has been selected, extensive in vitro and clinical studies are required to...other 2016
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Abeln, E. (author), Posno, M. (author)TNO’s intestinal screening model (TNO i-screen) helps to quickly identify food ingredients that modulate the intestinal microbiota composition. For manufacturers, searching for health-promoting ingredients is a complex and time-consuming process. Large numbers of substances have to be screened, while for some components almost no proper...other 2016
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van Nieuwenhuijzen, E.J. (author), Houbraken, J.A.M.P. (author), Meijer, M. (author), Adan, O.C.G. (author), Samson, R.A. (author)The genus Aureobasidium, which is known as a wood staining mould, has been detected on oil treated woods in the specific stain formation called biofinish. This biofinish is used to develop a new protective, self-healing and decorative biotreatment for wood. In order to understand and control biofinish formation on oil treated wood, the...article 2016
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Lu, S. (author), Lin, H.X. (author), Heemink, A. (author), Segers, A. (author), . Fu, G. (author)In this paper, we reconstruct the vertical profile of volcanic ash emissions by assimilating satellite data and ground-based observations using a modified trajectory-based 4D-Var (Trj4DVar) approach. In our previous work, we found that the lack of vertical resolution in satellite ash column data can result in a poor estimation of the injection...article 2016
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Burello, E. (author)Nanomaterials are expected to find applications in numerous consumer products, posing the challenge to guarantee their safety and environmental sustainability before they can be transferred from research labs to end-consumer products. One emerging solution, called safe design, relies on the implementation, throughout the R&D phase, of key...article 2015
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Immers, B. (author), Hemelrijk, C. (author), Ploos van Amstel, W. (author), van den Heuvel, M.J.R. (author), Kooij, R. (author), van Voorden, A. (author), van Dooren, E. (author), Schuurman, W. (author), van der Mei, R. (author), Brazier, F. (author), Stam, K. (author)TrafficQuest ziet het als een van haar opgaven om het verkeersmanagementproces zo goed mogelijk te doorgronden en op basis van het begrip van het proces sturingsprincipes te traceren en uit te werken die toegepast kunnen worden bij het (beter) managen van verkeer in een wegennetwerk”. Eén van de manieren om meer inzicht in de processen te...report 2015
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Starokozhko, V. (author), Abza, G.B. (author), Maessen, H.C. (author), Merema, M.T. (author), Kuper, F. (author), Groothuis, G.M.M. (author)Precision-cut liver slices (PCLS) are an ex vivo model for metabolism and toxicity studies. However, data on the maintenance of the morphological integrity of the various cell types in the slices during prolonged incubation are lacking. Therefore, our aims were to characterize morphological and functional changes in rat PCLS during five days of...article 2015
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- van Merrienboer, S.A. (author) public lecture 2015
Searched for: subject%3A%22EELS%255C%2B%255C-%255C%2BEarth%252C%255C%2BEnvironmental%255C%2Band%255C%2BLife%22
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