Searched for: subject%3A%22Drug%255C%2Btoxicity%22
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Heijne, W.H. (author), Stierum, R.H. (author), Leeman, W.R. (author), van Ommen, B. (author), TNO Kwaliteit van Leven (author)
article 2005
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Franzaring, J. (author), Kempenaar, C. (author), van Eerden, L.J.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Chemicals/CAS: Benzofurans; Chlorpropham, 101-21-3; Environmental Pollutants; ethofumesate, 26225-79-6; Herbicides; Mesylates
article 2001
document
Til, H.P. (author), Bär, A. (author)
The oral toxicity of γ-cyclodextrin (γ- CD) was examined in a 13-week feeding study in which four groups of four male and four female Beagle dogs received γ-CD in the diet at concentrations of 0 (control), 5, 10, or 20%. No treatment-related changes were noted in behavior or appearance of the dogs and no mortalities occurred. Transient diarrhea...
article 1998
document
Lina, B.A.R. (author), Bär, A. (author)
The toxicity of γ-cyclodextrin (γ-CD), a cyclic polymer of eight α-1,4-linked glucopyranosyl units with potential applications as a food ingredient, was examined in a 2-week pilot study followed by a 13-week oral toxicity study in Wistar rats. In the 2-week study, the test substance was administered to groups of 5 male rats at dietary levels of...
article 1998
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Stouten, H. (author), Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding (author)
As part of a health-hazard survey on the health risk of hospital cleaning workers from exposure to Lyorthol, a hazard assessment of o-phenylphenol (and its sodium salt), one of the constituents of Lyorthol, has been prepared, In this paper, the physical and chemical characteristics, kinetics and effects of o-phenylphenol and its sodium salt are...
article 1998
document
Til, H.P. (author), Modderman, J. (author), TNO Voeding (author)
Erythritol was orally administered to Wistar rats at dietary levels of 0, 5, and 10% for 4 weeks. Soft stools and diarrhea were observed in male and female animals of the 10% group and in female animals of the 5% group. These symptoms disappeared during the course of the study. Mean body weights of male rats in the high-dose group were...
article 1996
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Brouwer, R. (author), Brouwer, D.H. (author), Tijssen, S.C.H.A. (author), van Hemmen, J.J. (author), Medisch Biologisch Laboratorium TNO (author)
The relationship between the levels of dermal and respiratory exposure to pesticides and the amount of pesticide on the leaves of the plants has been studied during cutting of carnations in greenhouses. The study was focused on four pesticides and performed in 18 farms in the Netherlands. Dermal exposure measured by using long-sleeved cotton...
article 1992
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Jonker, D. (author), Woutersen, R.A. (author), van Bladeren, P.J. (author), Til, H.P. (author), Feron, V.J. (author)
In a 4-wk oral toxicity study, 4-wk-old male and female Wistar rats were exposed to a combination of arbitrarily chosen chemicals comprising sodium metabisulphite, Mirex, Loperamide, metaldehyde, di-n-octyltin dichloride, stannous chloride, lysinoalanine and potassium nitrite. The dose levels used were based on the 'no-observed-adverse-effect...
article 1990
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Appelman, L.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The toxicity data of 66 compounds adequately tested in the rat (as 'prime animal species') and in the dog (as 'second animal species') were studied to find out for how many of these compounds the study in dogs led to a lower 'no-toxic-effect level' (NTEL) than that found in the rat. From a quantitative point of view such information would...
article 1986
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Til, H.P. (author), Feron, V.J. (author), Immel, H.R. (author), Vogel, W.F. (author), Instituut CIVO-Toxicologie en voeding TNO (author)
article 1986
document
Medisch Biologisch Laboratorium TNO (author), Kulig, B.M. (author), Vanwersch, R.A.P. (author), Wolthuis, O.L. (author)
The effects of CNS-active drugs and neurotoxic agents on motor coordination in the rat were studied using a newly developed, automated technique. In this test, a tv/microprocessor-based system was utilized to detect and describe the movement and placement characteristics of one of the rat's hindpaws as the rat placed its paw from one rung to...
article 1985
document
Koëter, H.B.W.M. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Toxicity data of 37 compounds tested in both a subchronic study and one or more studies focused on reproduction were evaluated to obtain information on the significance of fertility and reproduction parameters in setting no-effect levels (NEL). It appeared that a) the test system aimed at reproduction and development was more sensitive than the...
article 1983
document
Appelman, L.M. (author), ten Berge, W.F. (author), Reuzel, P.G.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The acute inhalation toxicity of ammonia was examined in rats using various exposure concentrations and exposure periods. Groups of male and female rats were exposed to dynamic atmospheres containing different concentrations of ammonia for 10, 20, 40 or 60 min. The aim of the study was to establish the relationship between exposure concentration...
article 1982
document
Centraal Instituut voor Voedingsonderzoek TNO (author), Appelman, L.M. (author), Woutersen, R.A. (author), Feron, V.J. (author)
The 4-h LC50 of acetaldehyde in rats was determined and found to be 13,300 ppm (24.0 g/m3 air). In a 4-week study groups of 10 male and 10 female rats were exposed to 0, 400, 1000, 2200 or 5000 ppm acetaldehyde for 6 h/day, 5 days/week. Treatment-related changes observed at the 5000 ppm level included dyspnoea and excitation during the first 30...
article 1982
document
Appelman, L.M. (author), Hendriksen, C.F.M. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The subacute inhalation toxicity of ??-ethylacrolein was examined in rats by repeated exposure of 4 groups of 10 males and 10 females each to ??-ethylacrolein vapour at concentrations of 0, 2.0, 9.8 or 48.4 ppm, respectively, (6 h/day, 5 days/week) for a period of 13 weeks. The effects at 48.4 ppm were found to include growth retardation, focal...
article 1981
document
Feron, V.J. (author), Hendriksen, C.F.M. (author), Speek, A.J. (author), Til, H.P. (author), Spit, B.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
A lifespan oral toxicity of vinyl chloride monomer (VCM) was carried out in Wistar rats, using five groups each of 60-80 males and 60-80 females. VCM was administered by incorporating polyvinyl chloride (PVC) powder with a high VCM content into the diet or by gastric intubation of a 10% VCM solution in soya-bean oil. The VCM doses (actual...
article 1981
document
Grollé, T. (author), Kuiper, J. (author), Hoofdgroep Maatschappelijke Technologie TNO (author)
article 1980
document
Plooy, A.C.M. (author), Lohman, P.H.M. (author), Medisch Biologisch Laboratorium TNO (author)
Ten platinum (Pt) coordination complexes with different ligands, comprising both Pt(II) and Pt(IV) complexes of which the cis-compounds all possessed at least some anti-tumour activity and the trans-compounds were inactive, were tested as to their effect on cell survival and the induction and repair of DNA damage in cultured Chinese hamster...
article 1980
document
Feron, V.J. (author), Kroes, R. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
Wistar rats were exposed to atmospheres containing 0 (control) or 5000 ppm vinyl chloride monomer (VCM), 7 h/day, 5 days/week, for a period of 52 weeks. After 4, 13, 26 and 52 weeks each time 10 rats/sex/group were killed and subjected to extensive examinations. The present paper describes the morphological changes observed in the respiratory...
article 1979
document
Feron, V.J. (author), Kruysse, A. (author), Dreef Van Der Meulen, H.C. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The sub-acute inhalation toxicity of furfural was studied in Syrian golden hamsters. Four groups of ten males and ten females each were repeatedly exposed to furfural vapour at concentrations of 0, 20, 115 and 552 ppm (0, 77,448 and 2165 mg/m3 air) respectively for 6 hours/day, 5 days/week during a period of 13 weeks. At the highest exposure...
article 1979
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