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Schutte, M.E. (author), Boersma, M.G. (author), Verhallen, D.A.M. (author), Groten, J.P. (author), Rietjens, I.M.C.M. (author), TNO Kwaliteit van Leven (author)This study describes and kinetically models the effect of flavonoid mixtures on PhIP transport through Caco-2 monolayers. Previously it was shown that quercetin, luteolin, naringenin and myricetin increase the apical to basolateral PhIP transport in Caco-2 monolayers. In this study, apigenin was shown to exert a similar effect with an apparent...article 2008
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de Haan, W. (author), de Vries-van der Weij, J. (author), van der Hoorn, J.W.A. (author), Gautier, T. (author), van der Hoogt, C.C. (author), Westerterp, M. (author), Romijn, J.A. (author), Jukema, J.W. (author), Havekes, L.M. (author), Princen, H.M.G. (author), Rensen, P.C.N. (author)BACKGROUND - Although cholesteryl ester transfer protein (CETP) inhibition is regarded as a promising strategy to reduce atherosclerosis by increasing high-density lipoprotein cholesterol, the CETP inhibitor torcetrapib given in addition to atorvastatin had no effect on atherosclerosis and even increased cardiovascular death in the recent...article 2008
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Hendriksen, P.J.M. (author), Freidig, A.P. (author), Jonker, D. (author), Thissen, U. (author), Bogaards, J.J.P. (author), Mumtaz, M.M. (author), Groten, J.P. (author), Stierum, R.H. (author), TNO Kwaliteit van Leven (author)The present research aimed to study the interaction of three chemicals, methyl mercury, benzene and trichloroethylene, on mRNA expression alterations in rat liver and kidney measured by microarray analysis. These compounds were selected based on presumed different modes of action. The chemicals were administered daily for 14 days at the Lowest...article 2007
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Staal, Y.C.M. (author), Hebels, D.G.A.J. (author), van Herwijnen, M.H.M. (author), Gottschalk, R.W.H. (author), van Schooten, F.J. (author), van Delft, J.H.M. (author), TNO Kwaliteit van Leven (author)Polycyclic aromatic hydrocarbons (PAHs) cover a wide range of structurally related compounds which differ greatly in their carcinogenic potency. PAH exposure usually occurs through mixtures rather than individual compounds. Therefore, we assessed whether the effects of binary PAH mixtures on gene expression, DNA adduct formation, apoptosis and...article 2007
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TNO Kwaliteit van Leven (author), van der Hoorn, J.W.A. (author), Kleemann, R. (author), Havekes, L.M. (author), Kooistra, T. (author), Princen, H.M.G. (author), Jukema, J.W. (author)AIM: This study was designed to investigate the effect of the angiotensin II receptor blocker olmesartan alone, or in combination with standard treatment with a statin, pravastatin, on atherosclerosis development in APOE*3Leiden transgenic mice. METHODS AND RESULTS: Four groups of 15 mice received an atherogenic diet alone (plasma cholesterol 17...article 2007
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Collen, A. (author), Hanemaaijer, R. (author), Lupu, F. (author), Quax, P.H.A. (author), van Lent, N. (author), Grimbergen, J. (author), Peters, E. (author), Koolwijk, P. (author), van Hinsbergh, V.W.M. (author), Gaubius Instituut TNO (author)Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly of fibrin but is intermingled with plasma proteins and collagen fibers. The formation of capillary structures in a fibrinous matrix in vivo was mimicked by an in vitro model, in which...article 2003
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Tajima, O. (author), Schoen, E.D. (author), Feron, V.J. (author), Groten, J.P. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)This paper presents a test strategy to detect interactive effects between several mycotoxins using a DNA synthesis inhibition assay in L929 cells. The joint action of the Fusarium mycotoxins T-2 toxin (T2), deoxynivalenol (DON), nivalenol (NIV), zearalenone (ZEA) and fumonisin (FB1) was studied in a tiered approach. In the first stage, the...article 2002
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Gaubius Instituut TNO (author), van de Poll, S.W.E (author), D.J.M Delsingl, , (author), Jukema, J.Wouter (author), Princen, H.M.G (author), Havekes, L.M. (author), Puppels, G.J. (author), van der Laarse, A. (author)Raman spectroscopy allows quantitative, non-destructive evaluation of entire, intact atherosclerotic plaques. We quantified the anti-atherosclerotic effects of atorvastatin and amlodipine on progression of atherosclerosis using post-mortem Raman spectroscopic plaque imaging in 28 APOE*3 Leiden transgenic mice who were fed a high fat/high...article 2002
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Korst, A.E.C. (author), Boven, E. (author), van der Sterre, M.L.T. (author), Fichtinger-Schepman, A.M.J. (author), van der Vijgh, W.J.F. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)Amifostine (Ethyol, WR-2721) is in use in the clinic as a protector against platinum-induced toxicities. We have previously reported that amifostine induced a potentiation of the antitumour activity of carboplatin in human ovarian cancer xenografts. An influence of amifostine on the pharmacokinetics of carboplatin, resulting in higher platinum...article 1998
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Cassee, F.R. (author), Groten, J.P. (author), van Bladeren, P.J. (author), Feron, V.J. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)A major objective of combination toxicology is to establish whether a mixture of chemicals will result in an effect similar to that expected on the basis of additivity. This requires understanding of the basic concepts of the combined toxicological action of the compounds of the mixture: simple similar action (dose addition), simple dissimilar...article 1998
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Centraal Instituut voor Voedingsonderzoek TNO (author), Korst, A.E.C. (author), Boven, E. (author), van der Sterre, M.L.T. (author), Fichtinger-Schepman, A.M.J. (author), van der Vijgh, W.J.F. (author)We have previously reported that amifostine potentiates the anti-tumour activity of carboplatin in mice. The present study was carried out in well-established human ovarian cancer xenografts OVCAR-3, A2780 and FMa grown subcutaneously in the nude mouse. It was found that a single dose of amifostine resulted in a higher increase in the anti...article 1997
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Jonker, D. (author), Woutersen, R.A. (author), Feron, V.J. (author), TNO Voeding (author)The toxicity of mixtures of chemicals with the same target organ was examined in rats using nephrotoxicants with similar or dissimilar modes of action. In a 4-wk feeding study, lysinoalanine, mercuric chloride, hexachloro-1,3-butadiene and d-limonene, each affecting renal proximal tubular cells but through different modes of action, were...article 1996
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Rijken, D.C. (author), Jie, A.F.H. (author), Gaubius Laboratory TNO Preventie en Gezondheid (author)Reteplase is a protein consisting of the kringle-2 and protease domains of tissue-type plasminogen activator (t-PA). Because intravenous heparin will be used as an adjunct to thrombolytic therapy with reteplase, we investigated the interactions in vitro between heparin and reteplase as well as between heparin and recombinant t-PA (alteplase) as...article 1996
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Schoen, E.D. (author), Technisch Physische Dienst TNO - TH (author)Combination toxicological studies with statistically designed experiments do not often elaborate on the qualities of the design. Therefore, it may seem that the design used is the only one to meet the objectives of the study. This article demonstrates, on the contrary, that there are often several possibilities. Three recent toxicological...article 1996
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Instituut CIVO-Toxicologie en Voeding TNO (author), Appel, M.J. (author), Woutersen, R.A. (author)In the present study the putative chemopreventive effect of dietary fish oil (MaxEPA) on azaserine-induced pancreatic carcinogenesis in rats was investigated. Groups of rats were maintained on a semipurified low-fat (LF; 5 wt%) diet or on semipurified high-fat (HF; 25 wt%) diets containing 5 wt% linoleic acid (LA) and including 0.0, 1.2, 2.4, 4...article 1996
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TNO Voeding (author), Meijers, M. (author), Appel, M.J. (author), van Garderen-Hoetmer, A. (author), Lamers, C.B.H.W. (author), Rovati, L.C. (author), Jansen, J.B.M.J. (author), Woutersen, R.A. (author)Cholecystokinin and bombesin have been shown to promote pancreatic growth and development of azaserine-induced acidophilic atypical acinar cell nodules in rat pancreas after treatment for 16 weeks. Lorglumide, a specific cholescystokinin receptor antagonist, inhibited the stimulating effect of cholecystokinin, but not of bombesin. The present...article 1992
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Centraal Instituut voor Voedingsonderzoek TNO (author), Jonker, D. (author), Woutersen, R.A. (author), van Bladeren, P.J. (author), Til, H.P. (author), Feron, V.J. (author)In a 4-wk oral toxicity study, 4-wk-old male and female Wistar rats were exposed to a combination of arbitrarily chosen chemicals comprising sodium metabisulphite, Mirex, Loperamide, metaldehyde, di-n-octyltin dichloride, stannous chloride, lysinoalanine and potassium nitrite. The dose levels used were based on the 'no-observed-adverse-effect...article 1990
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- Rutten, A.A.J.J.L. (author), Wilmer, J.W.G.M. (author), Instituut CIVO-Toxicologie en voeding TNO (author) article 1986
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Instituut CIVO-Toxicologie en voeding TNO (author), Kroes, R. (author), Beems, R.B. (author), Bosland, M.C. (author), Bunnik, G.S.J. (author), Sinkeldam, E.J. (author)Dietary factors are now considered to be among the most important environmental risk determinations for cancer. In addition to epidemiological studies, experimental animal studies are an important tool to investigate dietary modulation in carcinogenesis. Results of recent experimental studies on the effect of some nutrients indicate that vitamin...conference paper 1986
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Kepner, L.A. (author), Wolthuis, O.L. (author), Medisch Biologisch Laboratorium TNO (author)The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen...article 1978
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