Searched for: subject:"Double%5C-Blind%5C%2BMethod"
(1 - 18 of 18)
document
Hellgren, M. (author), Conard, J. (author), Norris, L. (author), Kluft, C. (author), TNO Kwaliteit van Leven (author)
Objective: To study cardiovascular risk markers in women taking estradiol/trimegestone or estradiol/dydrogesterone. Design: Multicenter, randomized, prospective, double-blind study of 184 healthy post-menopausal women randomized to 6 cycles of either estradiol (2 mg) + trimegestone (0.5 mg) (T-group) or estradiol (2 mg) + dydrogesterone (10 mg) ...
article 2009
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van Uffelen, J.G.Z. (author), Chinapaw, M.J.M. (author), van Mechelen, W. (author), Hopman-Rock, M. (author), TNO Kwaliteit van Leven (author)
Objective: To examine the effects of aerobic exercise or vitamin B supplementation on cognitive function in older adults with mild cognitive impairment (MCI). Design: Randomised placebo-controlled trial. Setting: General community. Participants: Community-dwelling adults aged 70-80 with MCI. Interventions : The 152 participants were randomly...
article 2008
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van Doorn, M. (author), Vogels, J. (author), Tas, A. (author), van Hoogdalem, E.J. (author), Burggraaf, J. (author), Cohen, A. (author), van der Greef, J. (author), TNO Kwaliteit van Leven (author)
Aims: To explore the usefulness of metabolomics as a method to obtain a broad array of biomarkers for the pharmacological effects of rosiglitazone (RSG) in plasma and urine samples from patients with type 2 diabetes mellitus (T2DM) and healthy volunteers (HVs). Additionally, we explored the differences in metabolite concentrations between T2DM...
article 2007
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van Vliet, T. (author), Jacobs, R.G.J.M. (author), de Deckere, E. (author), van den Berg, H. (author), de Bree, A. (author), van der Put, N.M.J. (author), TNO Kwaliteit van Leven (author)
Objective: To determine the effect of folic acid, vitamin B6 and B12 fortified spreads on the blood concentrations of these vitamins and homocysteine. Design and setting: A 6-week randomized, double-blinded, placebo-controlled, parallel trial carried out in a clinical research center. Subjects: One hundred and fifty healthy volunteers (50% males...
article 2007
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Peeters, K.A.B.M. (author), Koppelman, S.J. (author), van Hoffen, E. (author), van der Tas, C.W.H. (author), den Hartog Jager, C.F. (author), Penninks, A.H. (author), Hefle, S.L. (author), Bruijnzeel-Koomen, C.A.F.M. (author), Knol, E.F. (author), Knulst, A.C. (author), TNO Kwaliteit van Leven (author)
Background: Recognition of specific peanut allergens or the diversity of IgE binding to peanut allergens may play a role in the elicitation of severe allergic reactions. Objective: To investigate whether sensitization to individual allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 is correlated with clinical severity. Methods: The reactivity of...
article 2007
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van Doorn, M.B.A. (author), Espirito Santo, S.M. (author), Meijer, P. (author), Kamerling, I.M. (author), Schoemaker, R.C. (author), Dirsch, V. (author), Vollmar, A. (author), Haffner, T. (author), Gebhardt, R. (author), Cohen, A.F. (author), Princen, H.M. (author), Burggraaf, J. (author), TNO Kwaliteit van Leven (author)
Background: Epidemiologic studies suggest that garlic may have beneficial effects on risk factors associated with cardiovascular disease (CVD). However, these findings are not unambiguously supported by randomized placebo-controlled clinical trials. Objective: We sought to investigate the effects of a chemically well-characterized garlic...
article 2006
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Boelsma, E. (author), Lamers, R.-J.A.N. (author), Hendriks, H.F.J. (author), van Nesselrooij, J.H.J. (author), Roza, L. (author), TNO Voeding (author)
Ginkgo biloba extract has been advocated for the improvement of blood circulation in circulatory disorders. This study investigated the effect of the Gingko biloba extract EGb 761 on skin blood flow in healthy volunteers and accompanying changes in urinary metabolites. Twenty-seven healthy middle-aged subjects participated in a randomized,...
article 2004
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Albers, R. (author), van der Wielen, R.P.J. (author), Brink, E.J. (author), Hendriks, H.F.J. (author), Dorovska-Taran, V.N. (author), Mohede, I.C.M. (author), TNO Voeding (author)
Objectives: To study the effects of two different mixtures of the main conjugated linoleic acid (CLA) isomers cis-9, trans-11 CLA and trans-10, cis-12 CLA on human immune function. Design: Double-blind, randomized, parallel, reference-controlled intervention study. Subjects and intervention: Seventy-one healthy males aged 31-69y received one of...
article 2003
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Broekmans, W.M.R. (author), Klöpping-Ketelaars, I.A.A. (author), Weststrate, J.A. (author), Tijburg, L.B.M. (author), van Poppel, G. (author), Vink, A.A. (author), Berendschot, T.T.J.M. (author), Bots, M.L. (author), Castenmiller, W.A.M. (author), Kardinaal, A.F.M. (author)
Excessive consumption of energy and fat increases the risk for obesity. Snacks containing sucrose polyesters (SPE) as a dietary fat replacer are on the market in the United States. SPE products have been shown to lower concentrations of serum carotenoids in short-term studies. Experimental studies on the longer-term effects on health of...
article 2003
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Rhodes, L.E. (author), Shahbakhti, H. (author), Azurdia, R.M. (author), Moison, R.M.W. (author), Steenwinkel, M.J.S.T. (author), Homburg, M.I. (author), Dean, M.P. (author), McArdle, F. (author), Beijersbergen van Henegouwen, G.M.J. (author), Epe, B. (author), Vink, A.A. (author)
Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) protect against photocarcinogenesis in animals, but prospective human studies are scarce. The mechanism(s) underlying the photoprotection are uncertain, although ω-3 PUFAs may influence oxidative stress. We examined the effect of supplementation on a range of indicators of ultraviolet...
article 2003
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van de Ree, M.A. (author), de Maat, M.P. (author), Kluft, C. (author), Meinders, A.E. (author), Princen, H.M. (author), Huisman, M.V. (author), Gaubius Instituut TNO (author)
BACKGROUND: Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease, such as fibrinogen, von Willebrand factor (VWF), factor (F)VIIa, d-dimer and plasminogen activator inhibitor-1 (PAI-1). OBJECTIVES: To evaluate the effect of aggressive vs. standard dose atorvastatin on hemostatic...
article 2003
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van der Laan, W. (author), Molenaar, E. (author), Ronday, K. (author), Verheijen, J. (author), Breedveld, F. (author), Greenwald, R. (author), Dijkmans, B. (author), Tekoppele, J. (author), Gaubius instituut TNO (author)
Objective. To investigate the effects of doxycycline on disease activity and joint destruction in patients with rheumatoid arthritis (RA). Methods. A 36 week double blind, placebo controlled crossover trial was conducted. Patients (n = 66) received 50 mg doxycycline or placebo twice a day during 12, 24, or 36 weeks. Patient assessments were...
article 2001
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van den Heuvel, E.G.H.M. (author), Schoterman, M.H.C. (author), Muijs, T. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
The aim of this study was to investigate whether a product rich in transgalactooligosaccharides (TOS, Elix'or) stimulates true Ca absorption in postmenopausal women. The study was a double-blind, randomized crossover study, consisting of two 9-d treatment periods separated by a 19-d washout period. During the treatment periods, 12 subjects drank...
article 2000
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de Maat, M.P.M. (author), Kastelein, J.J.P. (author), Jukema, J.W. (author), Zwinderman, A.H. (author), Jansen, H. (author), Groenemeier, B. (author), Bruschke, A.V.G. (author), Kluft, C. (author), Gaubius instituut TNO (author)
Increased plasma fibrinogen levels have been identified as a risk indicator for myocardial infarction, stroke, and thrombosis. Both environmental and genetic factors make an important contribution to plasma fibrinogen levels in humans. In the present study we evaluated, in patients with serum cholesterol levels between 4 and 8 mmol/L, the...
article 1998
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Brussaard, H.E. (author), Gevers Leuven, J.A. (author), Frölich, M. (author), Kluft, C. (author), Krans, H.M.J. (author), Gaubius Instituut TNO (author)
Oestrogen replacement therapy is associated with a decreased risk of cardiovascular disease in postmenopausal women. Patients with non-insulin- dependent diabetes mellitus (NIDDM) have an increased cardiovascular risk. However, oestrogen replacement therapy is only reluctantly prescribed for patients with NIDDM. In a double blind randomized...
article 1997
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Kockx, M. (author), de Maat, M.P.M. (author), Knipscheer, H.C. (author), Kastelein, J.P. (author), Kluft, C. (author), Princen, H.M.G. (author), Kooistra, T. (author), Gaubius Instituut TNO (author)
Evaluation of fibrate treatment in humans has focused primarily on its anti-lipidaemic effects. A potentially favourable haemostasis-modulating activity of fibrates has also been recognized but the data are not consistent. We sought to learn more about this variability by examining the effects of gemfibrozil and ciprofibrate on plasma levels of...
article 1997
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de Maat, M.P.M. (author), Arnold, A.E.R. (author), van Buuren, S. (author), Wilson, J.H.P. (author), Kluft, C. (author), Gaubius Instituut TNO (author)
Elevated plasma fibrinogen levels are associated with an increased risk for cardiac events. Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases. The mechanism of this decrease has not yet been...
article 1996
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Smits, R.C.F. (author), Emmen, H.H. (author), Bertelmans, F.W. (author), Kulig, B.M. (author), van Loenen, A.C. (author), Polman, C.H. (author), Centraal Instituut voor Voedingsonderzoek TNO (author)
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could...
article 1994
Searched for: subject:"Double%5C-Blind%5C%2BMethod"
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