Lactotripeptides and antihypertensive effects: A critical review

Hypertension or high blood pressure is a significant health problem worldwide. Typically, lifestyle changes, including adopting a healthy diet, are recommended for people with an elevated blood pressure. Lactotripeptides are bioactive milk peptides with potential antihypertensive properties in man. These peptides, as part of a food product or as...

Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

Collagen deposits in fibrotic lesions often display elevated levels of hydroxyallysine (pyridinoline) cross-links. The relation between the occurrence of pyridinoline cross-links and the irreversibility of fibrosis suggests that these cross-links contribute to the aberrant accumulation of collagen. Based on its inhibitory effect on lysyl...

Influence of timing and dose of thyroid hormone replacement on development in infants with congenital hypothyroidism

Objectives: To test whether early treatment with a high initial dose of levothyroxine can prevent suboptimal mental development in all neonates with congenital hypothyroidism (CH). Study design: Sixty-one patients, 27 with severe CH and 34 with mild CH, were treated either early (

Inhibition of apolipoprotein(a) synthesis in cynomolgus monkey hepatocytes by retinoids via involvement of the retinoic acid receptor

We have shown previously that retinoids induce apolipoprotein (apo) A-I gene expression in cultured cynomolgus hepatocytes and do not have an effect on apo B-100 synthesis. In the present study, the effect of retinoids on apolipoprotein(a) (apo(a)) synthesis in cultured hepatocytes was investigated. The addition of all-trans retinoic acid (at-RA...

Studies on the mechanism of fibrate-inhibited expression of plasminogen activator inhibitor-1 in cultured hepatocytes from cynomolgus monkey

Fibrates are widely used drugs in hyperlipidemic disorders. In addition to lowering serum triglyceride levels, fibrates have also been shown to reduce elevated plasma plasminogen activator inhibitor-1 (PAI-1) levels in vivo. We demonstrate that fibrates suppress PAI-1 synthesis in cultured cynomolgus monkey hepatocytes in a concentration...

Changes in regional brain GFAP levels and behavioral functioning following subchronic lead acetate exposure in adult rats

Adult male WAG/Rij/MBL rats were dosed with lead acetate at 0, 4.0, 8.0 or 12.5 mg/kg, 5 days per week for 4 weeks. Animals were assessed prior to exposure, at the end of the 4-week exposure period and after a 2-week recovery period using a functional observational battery (FOB) and motor activity assessment. Rats were sacrificed two weeks after...

Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes

We have used primary monolayer cultures of rat hepatocytes to study the effects of physiological concentrations of various bile acids, commonly found in bile of normal rats, on the mechanism of regulation of cholesterol 7α-hydroxylase and bile acid synthesis. Addition of taurocholic acid, the most predominant bile acid in rat bile, to the...

Long-term changes in glial fibrillary acidic protein and calcium levels in rat hippocampus after a single systemic dose of kainic acid

Chemicals/CAS: calcium, 7440-70-2; kainic acid, 487-79-6; Biological Markers; Calcium, 7440-70-2; Glial Fibrillary Acidic Protein; Kainic Acid, 487-79-6; Neurotoxins

The digestion process of the sugar alcohol isomalt in the intestinal tract of the pig: 2 Studies with administration of isomalt as a sweet

In a study with ten pigs of 60-70 kg live weight, provided with a re-entrant cannula at the end of the ileum, and sixteen intact, non-cannulated pigs, the digestion and absorption of a dietary dose of 100 g isomalt/kg, and isomalt given between the meals as a 'sweet' on the basis of 50 and 100 g/kg feed consumption, were examined. In all three...

Glow curve analysis for constant temperature hot gas TLD readers

In constant temperature hot gas TLD systems the heating profile of the TL chip is an exponential function of time. A method is presented which enables glow curve deconvolution for non-linear heating systems. The reproducibility of the heating process of constant temperature hot gas systems can be such that a fast linear optimisation procedure...

Dissipation of aerosols from greenhouse air after application of pesticides using a low-volume technique implications for safe re-entry

The application of pesticides using Low-Volume (LV) techniques (volume rate < 50 l/ha) is of growing interest for crop protection in greenhouses. An important LV-technique is the Low Volume Mister (LVM), generating fine droplets (volume mean (aerodynamic) diameter varying from 14 up to 32 μm). Field experiments in a commercial greenhouse have...

Thrombolytic properties in a rabbit jugular vein thrombosis model of a tissue-type plasminogen activator mutant lacking the growth factor- and kringle 1-domains

Chemicals/CAS: Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68

Butyrate stimulates the secretion of apolipoprotein (apo) A-I and apo B100 by the human hepatoma cell line Hep G2. Induction of apo A-I mRNA with no change of apo B100 mRNA

Addition of sodium butyrate to the culture medium of the human hepatoma cell line Hep G2 resulted in a time- and dose-dependent increase in the secretion of apolipoprotein A-I (apo A-I) and apolipoprotein B100 (apo B100). After a 24 h preincubation period, a 2.4- and 2.2-fold increase in the secretion of apo A-I and apo B100 respectively was...