Searched for: subject:"Diseases"
(1 - 20 of 1,034)

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Schaafsma, F.G. (author), Hulsegge, G. (author), de Jong, M.A. (author), Overvliet, J. (author), van Rossum, E.F.C. (author), Nieuwenhuijsen, K. (author)
Objectives: Workplace-based selective prevention of mental health problems currently relies on subjective evaluation of stress complaints. Hair cortisol captures chronic stress responses and could be a promising biomarker for the early identification of mental health problems. The objective was to provide an overview of the state-of-the-art...
article 2021
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Donkers, J.M. (author), Eslami Amirabadi, H. (author), van de Steeg, E. (author)
Over the past decade, microfluidic intestine-on-a-chip models have been emerging as a novel platform to study intestinal function in health and disease. These microphysiological systems surpass conventional in vitro intestinal model systems, as they add microenvironmental context in the form of mechanical cues or by the incorporation of multiple...
article 2021
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A well-functioning immune system is critical for adequate responses to daily life health challenges such as infections. But at the same time, overshooting immune responses may lead to allergic and inflammatory diseases. Our immune balances are determined by a complex interplay between intrinsic properties such as our genome, and extrinsic...
other 2021
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van den Hoek, A.M. (author), Verschuren, L. (author), Caspers, M.P.M. (author), Worms, N. (author), Alonso, C. (author), Menke, A.L. (author), Princen, H.M.G. (author)
Non-alcoholic steatohepatitis (NASH) is the most rapidly growing liver disease that is nevertheless without approved pharmacological treatment. Despite great effort in developing novel NASH therapeutics, many have failed in clinical trials. This has raised questions on the adequacy of preclinical models. Elafibranor is one of the drugs currently...
article 2021
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van Keulen, D. (author), van Koeverden, I.D. (author), Boltjes, A. (author), Princen, H.M.G. (author), van Gool, A.J. (author), Asselbergs, F.W. (author), Tempel, D. (author), Pasterkamp, G. (author), van der Laan, S.W. (author)
Background and Aims: Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expression, coronary artery calcification burden and...
article 2021
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Singh, S. (author), Offringa-Hup, A.K. (author), Logtenberg, S.J.J. (author), van der Linden, P.D. (author), Janssen, W.M.T. (author), Klein, H. (author), Waanders, F. (author), Simsek, S. (author), de Jager, C.P.C. (author), Smits, S. (author), vn der Feltz, M. (author), Beumer, G.J. (author), Widrich, C. (author), Nap, M. (author), Pinto-Sietsma, S.J. (author)
article 2021
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Wit, J.M. (author), Sas, T.C.J. (author), Ranke, M.B. (author), van Dommelen, P. (author)
Background/aims: We hypothesized that modelling catch-up growth (CUG) as developed for coeliac disease (CD), might also fit CUG in adequately treated children with juvenile hypothyroidism (JHT) or growth hormone deficiency (GHD). Methods: We used a monomolecular function for all available prepubertal data on height SDS minus target height SDS ...
article 2021
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Giordano, L. (author), Mihaila, S.M. (author), Eslami Amirabadi, H. (author), Masereeuw, R. (author)
Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting an underlying complex pathophysiology that is thought to be vastly modulated by the bidirectional gut–kidney crosstalk. By combining advances in tissue engineering, biofabrication, microfluidics, and biosensors, microphysiological systems (MPSs) have...
article 2021
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van Eijk, L.E. (author), Binkhorst, M. (author), Bourgonje, A.R. (author), Offringa, A.K. (author), Mulder, D.J. (author), Bos, E.M. (author), Kolundzic, N. (author), Abdulle, A.E. (author), van der Voort, P.H.J. (author), Olde Rikkert, M.G.M. (author), van der Hoeven, J.G. (author), den Dunnen, W.F.A. (author), Hillebrands, J.L. (author), van Goor, H. (author)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread globally despite the worldwide implementation of preventive measures to combat the disease. Although most COVID-19 cases are characterised by a mild, self-limiting disease course, a considerable subset of patients...
article 2021
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Lankhaar, J.A.C. (author), Kemler, E. (author), Hofstetter, H. (author), Collard, D.C.M. (author), Zelissen, P.M.J. (author), Stubbe, J.H. (author), Backx, F.J.G. (author)
Awareness of physical activity (PA) constraints in patients with primary hypothyroidism on thyroid hormone replacement therapy (THR) is important. Hence, this cross-sectional matched case-control study aimed to determine PA and sports participation (SP) in patients with hypothyroidism on THR in comparison to control subjects. Accordingly, survey...
article 2021
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Oude Hengel, K.M. (author), Riumallo-Herl, C. (author), Schram, J.L.D. (author), Nieboer, D. (author), van der Beek, A.J (author), Burdorf, A. (author)
Objectives This study investigated the effects of a national early retirement reform, which was implemented in 2006 and penalized early retirement, on paid employment and different exit pathways and examined whether these effects differ by gender, income level and health status. Methods This study included all Dutch individuals in paid...
article 2021
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Li, A. (author), Chen, L. (author), Thomas, R.Z. (author), van der Velden, U. (author), Amaliya, A. (author), van der Sluis, L.W.M. (author), Schuller, A.A. (author), Tjakkes, G.H.E. (author)
Objectives: The reasons for tooth extraction are rarely recorded in epidemiological datasets. It poses a diagnostic challenge to determine if tooth loss is related to periodontal disease (TLPD). The present study aimed to assess the inter-tooth relationships based on the periodontal characteristics of existing teeth. Methods: A cross-sectional...
article 2021
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Griffiths, J.C. (author), de Vries, J. (author), McBurney, M.I. (author), Wopereis, S. (author), Serttas, S. (author), Marsman, D.S. (author)
Commonly, it is the end of life when our health is deteriorating, that many will make drastic lifestyle changes to improve their quality of life. However, it is increasingly recognized that bringing good health-promoting behaviors into practice as early in life as possible has the most significant impact across the maximal healthspan. The WHO...
article 2020
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Meima, M. (author), Kuijpers, E. (author), van Berg, C. (author), Kruizinga, A. (author), van Kesteren, N. (author), Spaan, S. (author)
This report is the final output of a major project that was commissioned to address exposure to biological agents in the workplace and the related health effects. The study included a scientific literature review, interviews with experts, focus group sessions and a stakeholder workshop. The report presents a consolidated summary of the outcomes...
report 2020
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Humalda, J.K. (author), Klaassen, G. (author), de Vries, H. (author), Meuleman, Y. (author), Verschuur, L.C. (author), Straathof, E.J.M. (author), Laverman, G.D. (author), Bos, W.J.W. (author), van der Boog, P.J.M. (author), Vermeulen, K.M. (author), Blanson Henkemans, O.A. (author), Otten, W. (author), de Borst, M.H. (author), van Dijk, S. (author), Navis, G.J. (author)
Rationale & objective: Patients with chronic kidney disease (CKD) are particularly sensitive to dietary sodium. We evaluated a self-management approach for dietary sodium restriction in patients with CKD. Study design: Randomized controlled trial. Setting & participants: Nephrology outpatient clinics in 4 Dutch hospitals. 99 adults with CKD...
article 2020
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Schram, J.L.D. (author), Robroek, S.J.W. (author), Ots, P. (author), Brouwer, S. (author), Burdorf, A. (author), van Zon, K.R. (author), Oude Hengel, K.M. (author)
Objectives To investigate the relation between changes in working conditions and exit from paid employment among workers with a chronic disease. Methods Six waves from the longitudinal Study on Transitions in Employment, Ability and Motivation (2010–2016), enriched with tax-based employment information from Statistics Netherlands (2011–2017),...
article 2020
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Holmgren, G. (author), Ulfenborg, B. (author), Asplund, A. (author), Toet, K. (author), Andersson, C.X. (author), Hammarstedt, A. (author), Hanemaaijer, J.R.O. (author), Küppers-Munther, B. (author), Synnergren, J. (author)
There is a strong anticipated future for human induced pluripotent stem cell-derived hepatocytes (hiPS-HEP), but so far, their use has been limited due to insufficient functionality. We investigated the potential of hiPS-HEP as an in vitro model for metabolic diseases by combining transcriptomics with multiple functional assays. The...
article 2020
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Pouwer, M.G. (author)
The thesis discussed several strategies that may contribute to further CVD risk reduction in the future. We described two novel lipid-lowering strategies, we unraveled (part of) the etiology of the cardiovascular safety issues of TKIs that are used for the treatment of CML, and we investigated the dose effects of PFOA on lipoprotein metabolism....
doctoral thesis 2020
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Dopsa, D.D. (author), Kronemeijer, A.J. (author), Gelinck, G. (author)
Integrating electronics with organ-on-chip-related technologies can assist in the development of better medicines, such as those for neurodegenerative and cardiovascular diseases. Holst Centre looks to contribute its flexible electronics and manufacturing expertise to the ecosystem. The early publication: The 3 dimensions of Organ-on-a-chip,...
other 2020
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Ots, P. (author), van Zon, K.R. (author), Schram, J.L.D. (author), Burdorf, A. (author), Robroek, S.J.W. (author), Oude Hengel, K.M. (author), Brouwer, S. (author)
Objectives. This study examined the risk of unhealthy behaviours and the additive effects of multiple unhealthy behaviours on exit from paid employment among workers with a chronic disease and investigated effect modification by gender and educational level. Methods. Data from the Lifelines cohort, collected between 2006 and 2013, were enriched...
article 2020
Searched for: subject:"Diseases"
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