Searched for: subject%3A%22Diseases%22
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Pronk, A. (author), Loh, M. (author), Kuijpers, E. (author), Albin, M. (author), Selander, J. (author), Godderis, L. (author), Ghosh, M. (author), Vermeulen, R. (author), Peters, S. (author), Sivesind Mehlum, I. (author), Turner, M. (author), Schlunssen, V. (author), Goldberg, M. (author), Kogevinas, M. (author), Harding, B. (author), Solovieva, S. (author), Garani-Papadatos, T. (author), van Tongeren, M. (author), Stierum, R. (author)
Exposures at work have a major impact on noncommunicable diseases (NCDs). Current risk reduction policies and strategies are informed by existing scientific evidence, which is limited due to the challenges of studying the complex relationship between exposure at work and outside work and health. We define the working life exposome as all...
article 2022
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Bongers, C.C.W.G. (author), de Korte, J.Q. (author), Zwartkruis, M. (author), Levels, K. (author), Kingma, B.R.M. (author), Eijsvogels, T.M.H. (author)
The combination of an exacerbated workload and impermeable nature of the personal protective equipment (PPE) worn by COVID-19 healthcare workers increases heat strain. We aimed to compare the prevalence of heat strain symptoms before (routine care without PPE) versus during the COVID-19 pandemic (COVID-19 care with PPE), identify risk factors...
article 2022
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Komninos, D. (author), Ramos, L. (author), van der Heijden, G.W. (author), Morrison, M.C. (author), Kleemann, R. (author), van Herwaarden, A.E. (author), Kiliaan, A.J. (author), Arnoldussen, I.A.C. (author)
Obesity can disturb spermatogenesis and subsequently affect male fertility and reproduction. In our study, we aim to elucidate at which cellular level of adult spermatogenesis the detrimental effects of obesity manifest. We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr−/−.Leiden) mice, and studied...
article 2022
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Ostendorf, R. (author), Erpelinck, S. (author)
The Organ-on-a-Chip Early Research Program enables TNO to offer state-of-the-art technologies that help the pharmaceutical industry advance drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model human tissue functioning and accelerate compound development and testing. The Intestinal Epithelial Barrier...
other 2022
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Ostendorf, R. (author)
The Organ-on-a-Chip Early Research Program (ERP) has enabled TNO to offer a number of state-of-the-art technologies to help pharmaceutical and biotech companies advance and accelerate drug development. An accurate, viable alternative to animal testing, on-a-chip technologies model the workings of human tissue and accelerate compound development...
other 2022
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de Verhoeff, M.C. (author), Lobbezoo, F. (author), van Leeuwen, A.M. (author), Schuller, A.A. (author), Koutris, M. (author)
Background: Parkinson's disease (PD) is a neurodegenerative condition affecting the quality of life. Due to a worsening of oral health in PD patients with the progression of the disease, oral health-related quality of life (OHRQoL) could be impaired as well. Objectives: To assess whether PD patients in The Netherlands experience worse OHRQoL...
article 2022
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Vals-Delgado, C. (author), Alcala-Diaz, J.F. (author), Molina-Abril, H. (author), Roncero-Ramos, I. (author), Caspers, M.P.M. (author), Schuren, F.H.J. (author), van den Broek, T.J. (author), Luque, R. (author), Perez-Martinez, P. (author), Katsiki, N. (author), Delgado-Lista, J. (author), Ordovas, J.M. (author), van Ommen, B. (author), Camargo, A (author), Lopez-Miranda, J. (author)
Introduction: A distinctive gut microbiome have been linked to type 2 diabetes mellitus (T2DM). Objectives: We aimed to evaluate whether gut microbiota composition, in addition to clinical biomarkers, could improve the prediction of new incident cases of diabetes in patients with coronary heart disease. Methods: All the patients from the...
article 2022
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Gart, E. (author), Salic, K. (author), Morrison, M.C. (author), Giera, M. (author), Attema, J. (author), de Ruiter, C. (author), Caspers, M.P.M. (author), Schuren, F. (author), Bobeldijk-Pastorova, I. (author), Heer, M. (author), Qin, Y. (author), Kleemann, R. (author)
Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that is associated with gut dysbiosis, enhanced gut permeability, adiposity and insulin resistance. Prebiotics such as human milk oligosaccharide 2'-fucosyllactose are thought to primarily improve gut health and it is uncertain whether they would affect more distant...
article 2022
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Grinberg, M. (author), Stöber, R.M. (author), Edlund, K. (author), Rempel, E. (author), Godoy, P. (author), Reif, R. (author), Widera, A. (author), Madjar, K. (author), Schmidt-Heck, W. (author), Marchan, R. (author), Sachinidis, A. (author), Spitkovsky, D. (author), Hescheler, J. (author), Carmo, H. (author), Arbo, M.D. (author), van de Water, B. (author), Wink, S. (author), Vinken, M. (author), Rogiers, V. (author), Escher, S. (author), Hardy, B. (author), Mitic, D. (author), Myatt, G. (author), Waldmann, T. (author), Mardinoglu, A. (author), Damm, G. (author), Seehofer, D. (author), Nüssler, A. (author), Weiss, T.S. (author), Oberemm, A. (author), Lampen, A. (author), Schaap, M.M. (author), Luijten, M. (author), van Steeg, H. (author), Thasler, W.E. (author), Kleinjans, J.C.S. (author), Stierum, R.H. (author), Leist, M. (author), Rahnenführer, J. (author), Hengstler, J.G. (author)
Correction to: Arch Toxicol (2014) 88:2261–2287 https://doi.org/10.1007/s00204-014-1400-x.
article 2022
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van den Bossche, S. (author), Dhondt, S. (author), Fransman, W. (author)
The world of work is changing at an ever-increasing rate. Digitalisation, with the COVID-19 pandemic as a catalyst, climate change and demographic developments are causing shifts in the labour market. Some jobs are changing, others are disappearing and new jobs are taking their place. These changes offer opportunities, but are at the same time...
other 2022
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van Eijk, L.E. (author), Offringa, A.K. (author), Bernal, M.E. (author), Bourgonje, A.R. (author), van Goor, H. (author), Hillebrands, J.L. (author)
Taurine is an amino sulfonic acid that is implicated in numerous physiological functions, including the regulation of oxidative stress, which plays an important role in coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), together with other pathophysiological processes. The recent finding...
article 2022
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Rafiq, R. (author), Aleva, F.E. (author), Schrumpf, J.A. (author), Daniels, J.M. (author), Bet, P.M. (author), Boersma, W.G. (author), Bresser, P. (author), Spanbroek, M. (author), Lips, P. (author), van den Broek, T.J. (author), Keijser, B.J.F. (author), van der Ven, J.A.M. (author), Hiemstra, P.S. (author), den Heijer, M. (author), de Jongh, R.T. (author), PRECOVID-study group, (author)
Background. Vitamin D deficiency is frequently found in patients with chronic obstructive pulmonary disease (COPD). Vitamin D has antimicrobial, anti-inflammatory, and immunomodulatory effects. Therefore, supplementation may prevent COPD exacerbations, particularly in deficient patients. Objectives. We aimed to assess the effect of vitamin D...
article 2022
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Carracedo, M. (author), Pawelzik, S.C. (author), Artiach, G. (author), Pouwer, M.G. (author), Plunde, O. (author), Saliba-Gustafson, P. (author), Ehrenborg, E. (author), Eriksson, P. (author), Pieterman, E. (author), Stenke, L. (author), Princen, H.M.G. (author), Franco-Cereceda, A. (author), Bäck, M. (author)
Background and purpose: Tyrosine kinase inhibitors (TKI) used to treat chronic myeloid leukemia (CML) have been associated with cardiovascular side effects, including reports on calcific aortic valve stenosis. The aim of this study was to establish the effects of first and second generation TKIs in aortic valve stenosis, and to determine the...
article 2022
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Li, A. (author), Chen, L. (author), Thomas, R.Z. (author), van der Velden, U. (author), Amaliya, A. (author), van der Sluis, L.W.M. (author), Schuller, A.A. (author), Tjakkes, G.H.E. (author)
Objectives: The reasons for tooth extraction are rarely recorded in epidemiological datasets. It poses a diagnostic challenge to determine if tooth loss is related to periodontal disease (TLPD). The present study aimed to assess the inter-tooth relationships based on the periodontal characteristics of existing teeth. Methods: A cross-sectional...
article 2021
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Schaafsma, F.G. (author), Hulsegge, G. (author), de Jong, M.A. (author), Overvliet, J. (author), van Rossum, E.F.C. (author), Nieuwenhuijsen, K. (author)
Objectives: Workplace-based selective prevention of mental health problems currently relies on subjective evaluation of stress complaints. Hair cortisol captures chronic stress responses and could be a promising biomarker for the early identification of mental health problems. The objective was to provide an overview of the state-of-the-art...
article 2021
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Donkers, J.M. (author), Eslami Amirabadi, H. (author), van de Steeg, E. (author)
Over the past decade, microfluidic intestine-on-a-chip models have been emerging as a novel platform to study intestinal function in health and disease. These microphysiological systems surpass conventional in vitro intestinal model systems, as they add microenvironmental context in the form of mechanical cues or by the incorporation of multiple...
article 2021
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A well-functioning immune system is critical for adequate responses to daily life health challenges such as infections. But at the same time, overshooting immune responses may lead to allergic and inflammatory diseases. Our immune balances are determined by a complex interplay between intrinsic properties such as our genome, and extrinsic...
other 2021
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Giordano, L. (author), Mihaila, S.M. (author), Eslami Amirabadi, H. (author), Masereeuw, R. (author)
Chronic kidney disease (CKD) typically appears alongside other comorbidities, highlighting an underlying complex pathophysiology that is thought to be vastly modulated by the bidirectional gut–kidney crosstalk. By combining advances in tissue engineering, biofabrication, microfluidics, and biosensors, microphysiological systems (MPSs) have...
article 2021
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van Eijk, L.E. (author), Binkhorst, M. (author), Bourgonje, A.R. (author), Offringa, A.K. (author), Mulder, D.J. (author), Bos, E.M. (author), Kolundzic, N. (author), Abdulle, A.E. (author), van der Voort, P.H.J. (author), Olde Rikkert, M.G.M. (author), van der Hoeven, J.G. (author), den Dunnen, W.F.A. (author), Hillebrands, J.L. (author), van Goor, H. (author)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread globally despite the worldwide implementation of preventive measures to combat the disease. Although most COVID-19 cases are characterised by a mild, self-limiting disease course, a considerable subset of patients...
article 2021
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Oude Hengel, K.M. (author), Burdorf, A. (author), Pronk, A. (author), Schlunssen, V. (author), Stokholm, Z.A. (author), Kolstad, H.A. (author), van Veldhoven, K. (author), Basinas, I. (author), van Tongeren, M. (author), Peters, S. (author)
Abstract from the 28th International Symposium on Epidemiology in Occupational Health EPICOH.
article 2021
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