- document
-
Brix, K.A. (author), Brody, D.L. (author), Grimes, J.B. (author), Yitzhak, A. (author), Agoston, D. (author), Aldag, M. (author), Armstrong, R. (author), Arun, P. (author), Audette, M. (author), Babcock, D. (author), Balaban, C. (author), Banton, R. (author), Bellgowan, P. (author), Borkholder, D. (author), Broglio, S. (author), Brokaw, E. (author), Cantu, R. (author), Carr, W. (author), Chapman, S. (author), Cmarik, J. (author), Colder, B. (author), Colombe, J. (author), Cook, D. (author), Cozzarelli, T. (author), Da Silva, U.O. (author), Daphalapurkar, N. (author), Dardzinski, B. (author), DeGraba, T. (author), DeMar, J. (author), DeWitt, D. (author), Dickstein, D. (author), Duckworth, J. (author), Elder, G. (author), Fazel-Rezai, R. (author), Fine, M. (author), Fiskum, G. (author), Fournier, A. (author), Ganpule, S. (author), Gill, J. (author), Glenn, J.F. (author), Greene, C. (author), Greig, N. (author), Haering, C. (author), Harrington, J. (author), Hein, A. (author), Helmick, K. (author), Hicks, R. (author), Hinds, S. (author), Hoffman, S. (author), Horkayne-Szakaly, I. (author), Iacono, D. (author), Ishii, E. (author), Jones, R.V. (author), Karami, G. (author), Krawczyk, D. (author), Labutta, R. (author), Latta, R. (author), Lattimore, T. (author), Leggieri, M. (author), Leonessa, F. (author), Lin, A. (author), Ling, G. (author), Long, M. (author), Lu, K.P. (author), Panker, S.M. (author), McCabe, J. (author), Merkle, A. (author), Montenigro, P. (author), Mueller, G.P. (author), Ng, L. (author), Nigam, S. (author), O'Donnell, J. (author), Okonkwo, D. (author), Pauli, I. (author), Perl, D. (author), Peskind, E. (author), Pfister, B. (author), Philippens, M. (author), Piehler, T. (author), Proctor, J. (author), Przekwas, A. (author), Qashu, F. (author), Raskind, M. (author), Razumovsky, A. (author), Reifman, J. (author), Reyes, P. (author), Rigby, P. (author), Risling, M. (author), Robinson, M. (author), Rooks, T. (author), Rosen, C. (author), Rosseau, G. (author), Sammons-Jackson, W. (author), Santago, A. (author), Shoge, R. (author), Sours, C. (author), Stone, J. (author), Templin, M. (author), Tepe, V. (author), Thielen, P. (author), Thomas, M. (author), Timmes, T. (author), Tortella, F. (author), Tucker, L. (author), Tweedie, D. (author), Hamm, D.V. (author), Christie Vu, B. (author), Wang, Y. (author), West, T. (author), Wilde, E. (author), Willis, A. (author), Wu, J. (author), Zai, L. (author), Zander, N. (author), Zheng, J. (author), Ziejewski, M. (author)The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury...article 2017
- document
-
Kooijman, S. (author), Meurs, I. (author), van der Stoep, M. (author), Habets, K.L. (author), Lammers, B. (author), Berbée, J.F.P. (author), Havekes, L.M. (author), van Eck, M. (author), Romijn, J.A. (author), Korporaal, S.J.A. (author), Rensen, P.C.N. (author)Summary: Background: The autonomic nervous system attenuates inflammation through activation of the α7 nicotinic acetylcholine receptor (α7nAChR), a pathway termed the cholinergic anti-inflammatory reflex. Interestingly, α7nAChR is expressed on immune cells and platelets, both of which play a crucial role in the development of atherosclerosis....article 2015
- document
-
A microsimulation model for the development and progression of chronic obstructive pulmonary diseaseTan, E. (author), Boessen, R. (author), Fishwick, D. (author), Klein Entink, R. (author), Meijster, T. (author), Pronk, A. (author), van Duuren-Stuurman, B. (author), Warren, N. (author)Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain. The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The...article 2015
- document
-
Busnadiego, O. (author), Gorbenko del Blanco, D. (author), González-Santamaría, J. (author), Habashi, J.P. (author), Calderon, J.F. (author), Sandoval, P. (author), Bedja, D. (author), Guinea-Viniegra, J. (author), Lopez-Cabrera, M. (author), Rosell-Garcia, T. (author), Snabel, J.M. (author), Hanemaaijer, R. (author), Forteza, A. (author), Dietz, H.C. (author), Egea, G. (author), Rodriguez-Pascual, F. (author)Patients with Marfan syndrome (MFS) are at high risk of life-threatening aortic dissections. The condition is caused by mutations in the gene encoding fibrillin-1, an essential component in the formation of elastic fibers. While experimental findings in animal models of the disease have shown the involvement of transforming growth factor-β (TGF...article 2015
- document
-
de Paula Faria, D. (author), Vlaming, M.L.H. (author), Copray, S.C.V.M. (author), Tielen, F. (author), Anthonijsz, H.J.A. (author), Sijbesma, J.W.A. (author), Buchpiguel, C.A. (author), Dierckx, R.A.J.O. (author), van der Hoorn, J.W.A. (author), de Vries, E.F.J. (author)The experimental autoimmune encephalomyelitis model is a model of multiple sclerosis that closely mimics the disease characteristics in humans. The main hallmarks of multiple sclerosis are neuroinflammation (microglia activation, monocyte invasion, and T-cell infiltration) and demyelination. PET imaging may be a useful noninvasive technique for...article 2014
- document
-
Wopereis, S. (author), Radonjic, M. (author), Rubingh, C. (author), van Erk, M. (author), Smilde, A. (author), van Duyvenvoorde, W. (author), Cnubben, N. (author), Kooistra, T. (author), van Ommen, B. (author), Kleemann, R. (author)The prevalence of diabetes mellitus Type 2 could be significantly reduced by early identification of subjects at risk, allowing for better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the prediabetic stage. This study aims at identifying 1) prognostic biomarkers predicting the risk of developing GI later in life...article 2012
- document
-
de Vries-van der Weij, J. (author), Toet, K. (author), Zadelaar, A.S.M. (author), Wielinga, P.Y. (author), Kleemann, R. (author), Rensen, P.C.N. (author), Kooistra, T. (author), TNO Kwaliteit van Leven (author)Objective: Inflammation plays an important role in all stages of atherosclerosis, but little is known about the therapeutic effects of quenching inflammation in already existing atherosclerotic lesions. Putative beneficial effects of salicylate, an inhibitor of NF-κB activation, were studied in mice with established lesions. Methods: ApoE*3...article 2010
- document
-
Eefting, D. (author), Bot, I. (author), de Vries, M.R. (author), Schepers, A. (author), van Bockel, J.H. (author), van Berkel, T.J.C. (author), Biessen, E.A.L. (author), Quax, P.H.A. (author), TNO Kwaliteit van Leven (author)Objective: Inflammatory responses to vascular injury are key events in vein graft disease and accelerated atherosclerosis, which may result in bypass failure. The monocyte chemoattractant protein-1 (MCP-1)/CC-chemokine receptor (CCR)-2 pathway is hypothesized to play a central role. A murine model for vein graft disease was used to study the...article 2009
- document
-
Pons, D. (author), de Vries, F.R. (author), van den Elsen, P.J. (author), Heijmans, B.T. (author), Quax, P.H.A. (author), Jukema, J.W. (author), TNO Kwaliteit van Leven (author)Significant progress has been made in the clinical management of a variety of cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current treatment modalities for atherosclerosis and restenosis is not fully sufficient in a large proportion of patients. One of the major contributing factors is the clinical and biological...article 2009
- document
-
Warren, N. (author), Meijster, T. (author), Heederik, D. (author), Tielemans, E. (author), TNO Kwaliteit van Leven (author)Objectives: This paper presents a dynamic population-based model for the development of sensitisation and respiratory symptoms in bakery workers. The model simulates a population of individual workers longitudinally and tracks the development of work-related sensitisation and respiratory symptoms in each worker. Methods: The model has three...article 2009
- document
-
Ketelslegers, I.A. (author), Boon, M. (author), Pereira, R.R. (author), Hintzen, R.Q. (author), Catsman-Berrevoets, C.E. (author), TNO Kwaliteit van Leven (author)Acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in children are relatively rare and the exact incidence is still unknown. There is great variability in clinical presentation and disease course. It is yet unclear which clinical and biological parameters can predict a chronic disease course and progression to multiple...article 2009
- document
-
TNO Kwaliteit van Leven (author), Verschuren, L. (author), van der Vries de Weij, J. (author), Zadelaar, A.S.M. (author), Kleemann, R. (author), Kooistra, T. (author)The aim of this study was to define the anti-atherosclerotic role of liver-X-receptors (LXRs) under lesion progressive and lesion regressive conditions, to establish a temporal line of events, and to gain insights into the mechanisms underlying the anti-atherogenic potency of LXRs. We used apoE*3Leiden (E3L) mice to comprehensively and time...article 2009
- document
-
Brenninkmeijer, V. (author), Houtman, I. (author), Blonk, R. (author), TNO Kwaliteit van Leven (author)Background: The World Health Organization considers depression a major health problem and a leading cause of disability. Aim To identify factors which may help to reduce depressive symptoms in a sample of employees sick listed due to mental health problems. Methods: Longitudinal cohort study of employees sick listed for 12-20 weeks due to mental...article 2008
- document
-
de Lau, L.M.L. (author), Cheung, E.Y.L. (author), Kluft, C. (author), Leebeek, F.W.G. (author), Meijer, P. (author), Laterveer, R. (author), Dippel, D.W.J. (author), de Maat, M.P.M. (author), TNO Kwaliteit van Leven (author)Ischemic stroke is associated with leucocyte activation. Activated leucocytes release elastase, an enzyme that can degrade fibrinogen. Fibrinogen elastase degradation products (FgEDP) may serve as a specific marker of elastase proteolytic activity. In a case-control study of 111 ischemic stroke patients and 119 controls, significantly higher...article 2008
- document
-
TNO Kwaliteit van Leven (author), van Dellen, Q.M. (author), van Aalderen, W.M.C. (author), Bindels, P.J.E. (author), Öry, F.G. (author), Bruil, J. (author), Stronks, K. (author), Wennink, J.M.B. (author), Wolf, B.H.M. (author), Mahdi, U. (author), Nagelkerke, A.F. (author), van der Veer, E.M.A. (author), Westra, M. (author)Background. Doctors and patients hold varying beliefs concerning illness and treatment. Patients' and families' explanatory models (EMs) vary according to personality and sociocultural factors. In a multi-ethnic society, it is becoming increasingly significant that doctors understand the different beliefs of their patients in order to improve...article 2008
- document
-
Spijkerman, A.M.W. (author), Gall, M.A. (author), Tarnow, L. (author), Twisk, J.W.R. (author), Lauritzen, E. (author), Lund-Andersen, H. (author), Emeis, J. (author), Parving, H.H. (author), Stehouwer, C.D.A. (author), TNO Kwaliteit van Leven (author)Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after...article 2007
- document
-
Oude Nijhuis, M.M. (author), van Keulen, J.K. (author), Pasterkamp, G. (author), Quax, P.H. (author), de Kleijn, D.P.V. (author), TNO Kwaliteit van Leven (author)Innate immunity is the first line of defence against invading micro-organisms. The family of Toll-like receptors (TLRs) recognizes pathogen-associated molecular patterns (PAMPs) that are carried by the invading micro-organisms. Infectious pathogens have been implicated to play an important role in atherosclerosis. Nowadays, evidence is...article 2007
- document
-
TNO Kwaliteit van Leven (author), Alkemade, F.E. (author), de Gittenberger-Groot, A.C. (author), Schiel, A.E. (author), van Munsteren, J.C. (author), Hogers, B. (author), van Vliet, L.S.J. (author), Poelmann, R.E. (author), Havekes, L.M. (author), van Dijk, K.W. (author), de Ruiter, M.C. (author)OBJECTIVE - Maternal hypercholesterolemia is associated with a higher incidence and faster progression of atherosclerotic lesions in neonatal offspring. We aimed to determine whether an in utero environment exposing a fetus to maternal hypercholesterolemia and associated risk factors can prime the murine vessel wall to accelerated development of...article 2007
- document
-
van der Greef, J. (author), Hankemeier, T. (author), McBurney, R.N. (author), TNO Kwaliteit van Leven (author)Personalized medicine - defined as customized medical care for each patient's unique condition - in the broader context of personalized health, will make significant strides forward when a systems approach is implemented to achieve the ultimate in disease phenotyping and to create novel therapeutics that address system-wide molecular...article 2006
- document
-
Lopatinskaya, L. (author), Zwemmer, J. (author), Uitdehaag, B. (author), Lucas, K. (author), Polman, C. (author), Nagelkerken, L. (author), TNO Kwaliteit van Leven (author)TNF-α, IL-12p35, IL-12p40, IL-4, IL-10, TGF-β1, CCR3, CXCR3, CCR5, Fas and FasL mRNA levels in PBMC of 25 multiple sclerosis (MS) patients were quantified at baseline by real-time PCR according to a post-hoc study design. The baseline values of the different markers were analysed with respect to their correlation with the increase in disability...article 2006